Understanding the Potential Impact of a Combination HIV Prevention Intervention in a Hyper-Endemic Community

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Alsallaq, Ramzi A ^a   Baeten, Jared M ^a   Celum, Connie L ^a   Hughes, James P ^a   Abu Raddad, Laith J ^b,c,d   Barnabas, Ruanne V ^a,b   Hallett, Timothy B ^e  

^a UNIVERSITY OF WASHINGTON   (United States)

^b USA   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

ARTICLE; BEHAVIOR CHANGE; CIRCUMCISION; CONDOM; HIGH RISK BEHAVIOR; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; INFECTION PREVENTION; MATHEMATICAL MODEL; PATIENT COMPLIANCE; PATIENT COUNSELING; PRACTICE GUIDELINE; PREVALENCE; RISK REDUCTION; SOUTH AFRICA;

ADOLESCENT; ADULT; ANTI-RETROVIRAL AGENTS; CIRCUMCISION, MALE; COUNSELING; ENDEMIC DISEASES; HIV INFECTIONS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MODELS, STATISTICAL; PREVALENCE; PRIMARY PREVENTION; RISK-TAKING; SOUTH AFRICA;

EID: 84872782269     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054575     Document Type: Article

References (84)

1. Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, et al. (2005) Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med 2: e298.
2. Bailey RC, Moses S, Parker CB, Agot K, Maclean I, et al. (2007) Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. The Lancet 369: 643-656.
3. Gray RH, Kigozi G, Serwadda D, Makumbi F, Watya S, et al. (2007) Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. The Lancet 369: 657-666.
4. Weiss HA, Thomas SL, Munabi SK, Hayes RJ (2006) Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. Sex Transm Infect 82: 101-109; discussion 110.
5. Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, et al. (2010) Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 375: 2092-2098.
6. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. (2011) Prevention of HIV-1 Infection with Early Antiretroviral Therapy. N Engl J Med. Available: http://www.nejm.org/doi/full/10.1056/NEJMoa1105243#t=article. Accessed 2012 Dec 27.
7. Allen S, Tice J, Van de Perre P, Serufilira A, Hudes E, et al. (1992) Effect of serotesting with counselling on condom use and seroconversion among HIV discordant couples in Africa. BMJ 304: 1605-1609.
8. Nuwaha F, Tumwesigye E, Kasasa S, Asiimwe S, Wana G, et al. (2009) Population-level Changes in Knowledge of HIV Status, Stigma, and HIV Risk Behavior after District-wide Door-to-Door Voluntary Counseling and Testing: Bushenyi District, Uganda. 16th Conference on Retroviruses and Opportunistic Infections; 8-11 Feb; Montreal, Canada.
9. Fonner VA, Denison J, Kennedy CE, O'Reilly K, Sweat M, (2012) Voluntary counseling and testing (VCT) for changing HIV-related risk behavior in developing countries. Cochrane Database Syst Rev 9: CD001224.
10. Denison JA, O'Reilly KR, Schmid GP, Kennedy CE, Sweat MD, (2008) HIV voluntary counseling and testing and behavioral risk reduction in developing countries: a meta-analysis, 1990-2005. AIDS Behav 12: 363-373.
11. WHO (2011) Epidemic update and health sector progress towards Universal Access. Progress Report. Available: http://www.who.int/hiv/pub/progress_report2011/en/index.html. Accessed 2012 Jul 15.
12. Khumalo-Sakutukwa G, Morin SF, Fritz K, Charlebois ED, van Rooyen H, et al. (2008) Project Accept (HPTN 043): a community-based intervention to reduce HIV incidence in populations at risk for HIV in sub-Saharan Africa and Thailand. J Acquir Immune Defic Syndr 49: 422-431.
13. Sweat M, Morin S, Celentano D, Mulawa M, Singh B, et al. (2011) Community-based intervention to increase HIV testing and case detection in people aged 16-32 years in Tanzania, Zimbabwe, and Thailand (NIMH Project Accept, HPTN 043): a randomised study. Lancet Infect Dis 11: 525-532.
14. Tumwesigye E, Baeten J, Tumwebaze H, Kurth A, Revall J, et al. (2011) Potential of household-based HIV counseling and testing as a platform for targeted referral to HIV prevention and care in Uganda. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Rome, Italy, 17-20 July 2011. Abstract MOLBPE045.
15. Naik R, Tabana H, Binza W, Zemba W, Doherty T, et al. (2010) Acceptability of home-based HIV counselling and testing in a rural district in South Africa. XVIII International AIDS Conference 18-23 Jul. Vienna, Austria.
16. Menzies N, Abang B, Wanyenze R, Nuwaha F, Mugisha B, et al. (2009) The costs and effectiveness of four HIV counseling and testing strategies in Uganda. AIDS 23: 395-401.
17. Tumwesigye E, Wana G, Kasasa S, Muganzi E, Nuwaha F, (2010) High uptake of home-based, district-wide, HIV counseling and testing in Uganda. AIDS Patient Care STDS 24: 735-741.
18. Padian NS, McCoy SI, Manian S, Wilson D, Schwartlander B, et al. (2011) Evaluation of large-scale combination HIV prevention programs: essential issues. J Acquir Immune Defic Syndr 58: e23-28.
19. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG, (2009) Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 373: 48-57.
20. Montaner JS, Hogg R, Wood E, Kerr T, Tyndall M, et al. (2006) The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet 368: 531-536.
21. Garnett GP, Baggaley RF, (2009) Treating our way out of the HIV pandemic: could we, would we, should we? Lancet 373: 9-11.
22. Cohen MS, Mastro TD, Cates W Jr (2009) Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 373: 1077; author reply 1080-1071.
23. Ruark A, Shelton JD, Halperin DT, Wawer MJ, Gray RH (2009) Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 373: 1078; author reply 1080-1071.
24. Epstein H (2009) Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 373: 1078-1079; author reply 1080-1071.
25. Jurgens R, Cohen J, Tarantola D, Heywood M, Carr R (2009) Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 373: 1079; author reply 1080-1071.
26. Hsieh YH, de Arazoza H (2009) Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 373: 1079-1080; author reply 1080-1071.
27. Assefa Y, Lera M (2009) Universal voluntary HIV testing and immediate antiretroviral therapy. Lancet 373: 1080; author reply 1080-1081.
28. Dodd PJ, Garnett GP, Hallett TB, (2010) Examining the promise of HIV elimination by 'test and treat' in hyperendemic settings. AIDS 24: 729-735.
29. Lange JM, (2011) "Test and treat": is it enough? Clin Infect Dis 52: 801-802.
30. Hollingsworth TD, Anderson RM, Fraser C, (2008) HIV-1 transmission, by stage of infection. J Infect Dis 198: 687-693.
31. Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Li X, et al. (2005) Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 191: 1403-1409.
32. Anderson RM, Garnett GP, (2000) Mathematical models of the transmission and control of sexually transmitted diseases. Sex Transm Dis 27: 636-643.
33. Hallett TB, Gregson S, Mugurungi O, Gonese E, Garnett GP, (2009) Assessing evidence for behaviour change affecting the course of HIV epidemics: A new mathematical modelling approach and application to data from Zimbabwe. Epidemics 1: 108-117.
34. Alsallaq RA, Cash B, Weiss HA, Longini IM Jr, Omer SB, et al. (2009) Quantitative assessment of the role of male circumcision in HIV epidemiology at the population level. Epidemics 1: 139-152.
35. Hallett TB, Singh K, Smith JA, White RG, Abu-Raddad LJ, et al. (2008) Understanding the impact of male circumcision interventions on the spread of HIV in southern Africa. PLOS ONE 3: e2212.
36. Shisana O, Rehle TM, Simbayi LC, Zuma K, Jooste S, et al. (2009) South African national HIV prevalence, incidence, behaviour and communication survey 2008: A turning tide among teenagers? Cape Town: HSRC Press.
37. Mutevedzi PC, Lessells RJ, Heller T, Barnighausen T, Cooke GS, et al. (2010) Scale-up of a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes? Bull World Health Organ 88: 593-600.
38. Keiser O, Anastos K, Schechter M, Balestre E, Myer L, et al. (2008) Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America. Trop Med Int Health 13: 870-879.
39. Celum C, Wald A, Lingappa JR, Magaret AS, Wang RS, et al. (2010) Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med 362: 427-439.
40. Department of Health SA (2003) Demographic and Health Survey.
41. Department of Health SA (2012) HIV and AIDS and STI Strategic Plan for South Africa, 2012-2016. Available: http://www.doh.gov.za. Accessed 2012 Apr 3.
42. WHO (2010) Antiretroviral therapy for HIV infection in adults and adolescents recommendations for a public health approach. Available: http://whqlibdoc.who.int/publications/2010/9789241599764_eng.pdf. Accessed 2011 Dec 10.
43. The Epidemiology Unit of KwaZulu-Natal Department of Health:KwaZulu-Natal Epidemiology Bulletin (2005). Available: http://www.kznhealth.gov.za/epibulletin10.pdf.Accessed 2011 Dec 10.
44. Rosen S, Fox MP, Gill CJ, (2007) Patient retention in antiretroviral therapy programs in sub-Saharan Africa: a systematic review. PLOS Med 4: e298.
45. Robert CP, Casella G (2004) Monte Carlo Statistical Methods. New York: Springer-Verlag.
46. Department of Health SA (2009) National Antenatal Sentinel HIV and Syphilis Prevalence Survey 2008, South Africa. Available: http://journaids.org/images/uploads/keydocs/08_antenatal_prevalence.pdf. Accessed 2011 Dec 10.
47. Welz T, Hosegood V, Jaffar S, Batzing-Feigenbaum J, Herbst K, et al. (2007) Continued very high prevalence of HIV infection in rural KwaZulu-Natal, South Africa: a population-based longitudinal study. AIDS 21: 1467-1472.
48. Barnighausen T, Wallrauch C, Welte A, McWalter TA, Mbizana N, et al. (2008) HIV incidence in rural South Africa: comparison of estimates from longitudinal surveillance and cross-sectional cBED assay testing. PLOS One 3: e3640.
49. Rehle T (2010) Personal comunication.
50. Attia S, Egger M, Muller M, Zwahlen M, Low N, (2009) Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS 23: 1397-1404.
51. Over M (2010) The global AIDS transition: A feasible objective for AIDS policy (Center for Global Development, Washington, DC, 2010). Available: http://www.cgdev.org/content/publications/detail/1424143/. Accessed 2011 Dec 10.
52. Tumwesigye E, Asiimwe S, Muganzi E, Achom M, Kabatesi D, et al. (2008) High HIV Prevalence among Males in Discordant Partnerships in a Full Access Door-Door VCT Program in Rural Uganda. 15th Conference on Retroviruses and Opportunistic Infections; 3-6 Feb; Boston, MA.
53. Bendavid E, Brandeau ML, Wood R, Owens DK, (2010) Comparative effectiveness of HIV testing and treatment in highly endemic regions. Arch Intern Med 170: 1347-1354.
54. Tumwebaze H, Tumwesigye E, Baeten J, Kurth A, Revall J, et al. (2012) Household-Based HIV Counseling and Testing as a Platform for Referral to HIV Care and Medical Male Circumcision in Uganda: A Pilot Evaluation. PloS one 7: e51620.
55. Gray RH, Kiwanuka N, Quinn TC, Sewankambo NK, Serwadda D, et al. (2000) Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. AIDS 14: 2371-2381.
56. Baeten JM, Donnell D, Kapiga SH, Ronald A, John-Stewart G, et al. (2010) Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples. AIDS 24: 737-744.
57. Bunnell R, Ekwaru JP, Solberg P, Wamai N, Bikaako-Kajura W, et al. (2006) Changes in sexual behavior and risk of HIV transmission after antiretroviral therapy and prevention interventions in rural Uganda. AIDS 20: 85-92.
58. McClelland RS, Graham SM, Richardson BA, Peshu N, Masese LN, et al. (2010) Treatment with antiretroviral therapy is not associated with increased sexual risk behavior in Kenyan female sex workers. AIDS 24: 891-897.
59. Pearson CR, Kurth AE, Cassels S, Martin DP, Simoni JM, et al. (2007) Modeling HIV transmission risk among Mozambicans prior to their initiating highly active antiretroviral therapy. AIDS Care 19: 594-604.
60. Powers KA, Ghani AC, Miller WC, Hoffman IF, Pettifor AE, et al. (2011) The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study. Lancet 378: 256-268.
61. Mugglin C, Althoff K, Wools-Kaloustian K, Sterne J, Nash D, et al. (2012) Immunodeficiency at the Start of ART: Global View. 19th Conference on Retroviruses and Opportunistic infections, March 5-8, 2012. Seattle, Washington.
62. Rosen S, Fox MP, (2011) Retention in HIV care between testing and treatment in sub-Saharan Africa: a systematic review. PLOS Med 8: e1001056.
63. Hontelez JA, de Vlas SJ, Tanser F, Bakker R, Barnighausen T, et al. (2011) The impact of the new WHO antiretroviral treatment guidelines on HIV epidemic dynamics and cost in South Africa. PLOS One 6: e21919.
64. Schwartlander B, Stover J, Hallett T, Atun R, Avila C, et al. (2011) Towards an improved investment approach for an effective response to HIV/AIDS. Lancet 377: 2031-2041.
65. aids2031 (2010) Costs and Financing Working Group. The Long-Term Costs of HIV/AIDS in South Africa. Washington, DC: Results for Development Institute. Available: http://www.resultsfordevelopment.org/sites/resultsfordevelopment.org/files/aids2031_South-Africa_Report_FINAL2.pdf. Accessed 2011 Dec 10.
66. Kaldor JM, Wilson DP, (2010) How low can you go: the impact of a modestly effective HIV vaccine compared with male circumcision. AIDS 24: 2573-2578.
67. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, et al. (2012) Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med 367: 399-410.
68. Thigpen MC, Kebaabetswe PM, Paxton LA, Smith DK, Rose CE, et al. (2012) Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med 367: 423-434.
69. Morris M, Kretzschmar M, (1997) Concurrent partnerships and the spread of HIV. AIDS 11: 641-648.
70. Ghani AC, Garnett GP, (2000) Risks of acquiring and transmitting sexually transmitted diseases in sexual partner networks. Sex Transm Dis 27: 579-587.
71. Ghani AC, Swinton J, Garnett GP, (1997) The role of sexual partnership networks in the epidemiology of gonorrhea. Sex Transm Dis 24: 45-56.
72. Poole D, Raftery AE (2000) Inference for deterministic simulation models: The Bayesian melding approach. Alexandria, VA: American Statistical Association.
73. Johnson LF, Dorrington RE, Bradshaw D, Wyk VP-V, Rehle TM, (2009) Sexual behaviour patterns in South Africa and their association with the spread of HIV: Insights from a mathematical model. Demographic Research 21: 289-340.
74. Todd J, Glynn JR, Marston M, Lutalo T, Biraro S, et al. (2007) Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy. AIDS 21Suppl 6: S55-63.
75. Hollingsworth TD, Anderson RM, Fraser C, (2008) HIV-1 transmission, by stage of infection. The Journal of infectious diseases 198: 687-693.
76. Wandel S, Egger M, Rangsin R, Nelson KE, Costello C, et al. (2008) Duration from seroconversion to eligibility for antiretroviral therapy and from ART eligibility to death in adult HIV-infected patients from low and middle-income countries: collaborative analysis of prospective studies. Sex Transm Infect 84Suppl 1: i31-i36.
77. Brinkhof MW, Boulle A, Weigel R, Messou E, Mathers C, et al. (2009) Mortality of HIV-infected patients starting antiretroviral therapy in sub-Saharan Africa: comparison with HIV-unrelated mortality. PLOS Med 6: e1000066.
78. Lawn SD, Bekker LG, Myer L, Orrell C, Wood R, (2005) Cryptococcocal immune reconstitution disease: a major cause of early mortality in a South African antiretroviral programme. AIDS 19: 2050-2052.
79. Lawn SD, Myer L, Bekker LG, Wood R, (2006) Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control. AIDS 20: 1605-1612.
80. Padian NS, Shiboski SC, Jewell NP, (1991) Female-to-male transmission of human immunodeficiency virus. JAMA 266: 1664-1667.
81. Nicolosi A, Musicco M, Saracco A, Lazzarin A, (1994) Risk factors for woman-to-man sexual transmission of the human immunodeficiency virus. Italian Study Group on HIV Heterosexual Transmission. J Acquir Immune Defic Syndr 7: 296-300.
82. Davis KR, Weller SC, (1999) The effectiveness of condoms in reducing heterosexual transmission of HIV. Fam Plann Perspect 31: 272-279.
83. Cremin I, Nyamukapa C, Sherr L, Hallett TB, Chawira G, et al. (2010) Patterns of self-reported behaviour change associated with receiving voluntary counselling and testing in a longitudinal study from Manicaland, Zimbabwe. AIDS Behav 14: 708-715.
84. KwaZulu-Natal Department of Health (2006) Population Data. Available: http://www.kznhealth.gov.za/census/rates.pdf. Accessed 2011 Dec 10.