Metabolomic analysis of dynamic response and drug resistance of gastric cancer cells to 5-fluorouracil

Oncology Reports

Volumn 29, Issue 3, 2013, Pages 925-931

  Sasada, Shinsuke ^a   Miyata, Yoshihiro ^a   Tsutani, Yasuhiro ^a   Tsuyama, Naohiro ^b   Masujima, Tsutomu ^b   Hihara, Jun ^a   Okada, Morihito ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Amino acid; Fluorouracil; Gastric cancer; Mass spectrometry; Metabolomics; Proline dehydrogenase

Indexed keywords

FLUOROURACIL; GLUTAMIC ACID; MESSENGER RNA; PROLINE; PROLINE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ARTICLE; CANCER CELL; CANCER RESISTANCE; CONTROLLED STUDY; DRUG SENSITIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

AMINO ACIDS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENE EXPRESSION; HUMANS; METABOLOME; METABOLOMICS; PROLINE OXIDASE; RNA, MESSENGER; STOMACH NEOPLASMS; SUPEROXIDES; UP-REGULATION;

EID: 84872774554     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2182     Document Type: Article

References (27)

1. Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2006. CA Cancer J Clin 56: 106-130, 2006.
2. Koizumi W, Narahara H, Hara T, et al: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol 9: 215-221, 2008.
3. Cunningham D, Starling N, Rao S, et al: Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Eng J Med 358: 36-46, 2008.
4. Van Cutsem E, Moiseyenko VM, Tjulandin S, et al: Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol 24: 4991-4997, 2006. (Pubitemid 46631401)
5. Sumner LW, Mendes P and Dixon RA: Plant metabolomics: large-scale phytochemistry in the functional genomics era. Phytochemistry 62: 817-836, 2003. (Pubitemid 36262386)
6. Schauer N, Semel Y, Roessner U, et al: Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement. Nat Biotechnol 24: 447-454, 2006.
7. Plumb R, Granger J, Stumpf C, Wilson ID, Evans JA and Lenz EM: Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences. Analyst 128: 819-823, 2003. (Pubitemid 36897868)
8. Opstad KS, Bell BA, Griffiths JR and Howe FA: An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning (1)H NMR. NMR Biomed 21: 1138-1147, 2008.
9. 1H-NMR spectroscopy-based metabolite profiling of human cancer cell lines and response to chemotherapy. Magn Reson Med 63: 1172-1183, 2010.
10. Bayet-Robert M, Lim S, Barthomeuf C and Morvan D: Bio chemical disorders induced by cytotoxic marine natural products in breast cancer cells as revealed by proton NMR spectroscopy-based metabolomics. Biochem Pharmacol 80: 1170-1179, 2010.
11. Morvan D and Demidem A: Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethyl-nitrosourea reveals drug efficacy and tumor adaptive metabolic pathways. Cancer Res 67: 2150-2159, 2007. (Pubitemid 46424234)
12. Tsutani Y, Yoshida K, Sanada Y, et al: Decreased orotate phos-phoribosyltransferase activity produces 5-fluorouracil resistance in a human gastric cancer cell line. Oncol Rep 99: 2268-2273, 2008.
13. Hirayama A, Kami K, Sugimoto M, et al: Quantitative metabolome profling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 69: 4918-4925, 2009.
14. Chen JL, Tang HQ, Hu JD, et al: Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectro metry. World J Gastroenterol 16: 5874-5880, 2010.
15. Mohamed R, Varesio E, Ivosev G, et al: Comprehensive analytical strategy for biomarker identification based on liquid chromato-graphy coupled to mass spectrometry and new candidate confirmation tools. Anal Chem 81: 7677-7694, 2009.
16. Ogata H, Goto S, Sato K, Fujibuchi W, Bono H and Kanehisa M: KEGG: Kyoto encyclopedia of genes and genomics. Nucleic Acids Res 27: 29-34, 1999. (Pubitemid 29209394)
17. Horai H, Arita M, Kanaya S, et al: MassBank: A public repository for sharing mass spectral data for life sciences. J Mass Spectrom 45: 703-714, 2010.
18. Griffin JL and Shockcor JP: Metabolic profiles of cancer cells. Nat Rev Cancer 4: 551-561, 2004. (Pubitemid 38868624)
19. Dang CV and Semenza GL: Oncogenic alterations of metabolism. Trends Biochem Sci 24: 68-72, 1999. (Pubitemid 29346576)
20. Fox CJ, Hammerman PS and Thompson CB: Fuel feeds function: energy metabolism and the T-cell response. Nut Rev Immunol 5: 844-852, 2005. (Pubitemid 41581666)
21. Phang JM, Liu W and Zabirnyk O: Proline metabolism and microenvironmental stress. Annu Rev Nutr 30: 441-463, 2010.
22. Cascino A, Muscaritoli M, Cangiano C, et al: Plasma amino acid imbalance in patients with lung and breast cancer. Anticancer Res 15: 507-510, 2005.
23. Phang JM: The regulatory functions of proline and pyrroline-5-carboxylic acid. Curr Top Cell Regul 25: 91-132, 1985.
24. White TA, Krishnan N, Becker DF and Tanner JJ: Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilius. J Biol Chem 282: 14316-14327, 2007. (Pubitemid 47100433)
25. Liu Y, Borchert GL, Surazynski A and Phang JM: Proline oxidase, a p53-induced gene, targets COX-2/PDE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. Oncogene 27: 6729-6737, 2008.
26. Pandhare J, Cooper SK and Phang JM: Proline oxidase, a proapoptotic gene, is induced by triglitazone: evidence for both peroxisomal proliferator- activated receptor gamma-dependent and -independent mechanisms. J Biol Chem 281: 2044-2052, 2006. (Pubitemid 43845792)
27. Liu Y, Borchert GL, Donald SP, Diwan BA, Anver M and Phang JM: Proline oxidase functions as a mitochondrial tumor suppressor in human cancers. Cancer Res 69: 6414-6422, 2009.