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Volumn 29, Issue 3, 2012, Pages 1948-1955

Old issues and new perspectives on prostate cancer hormonal therapy: The molecular substratum

Author keywords

Androgen receptor; Depletion; Hormonal therapy; Molecular mechanisms; Prostate cancer; Second line; Stem cell; Treatment

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; CHROMOGRANIN A; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; STAT PROTEIN; VASCULOTROPIN RECEPTOR;

EID: 84872766929     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-9991-z     Document Type: Article
Times cited : (13)

References (51)
  • 1
    • 84928580276 scopus 로고
    • Studies of prostate cancer I. The effect of castration, of oestrogen and of androgen injection on serum phosphatases in metastatic carcinoma f the prostate
    • Huggins C, Hodges CV. Studies of prostate cancer I. The effect of castration, of oestrogen and of androgen injection on serum phosphatases in metastatic carcinoma f the prostate. Cancer Res. 1941;1:293-301.
    • (1941) Cancer Res , vol.1 , pp. 293-301
    • Huggins, C.1    Hodges, C.V.2
  • 2
    • 0028805834 scopus 로고
    • Hormone-refractory (D3) prostate cancer: Refining the concept
    • Scher HI, Steineck G, Kelly WK. Hormone-refractory (D3) prostate cancer: refining the concept. Urology. 1995;46:142-8.
    • (1995) Urology , vol.46 , pp. 142-8
    • Scher, H.I.1    Steineck, G.2    Kelly, W.K.3
  • 3
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak DP, Tangen CM, Hussain MHA, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. 2004;351: 1513-20.
    • (2004) N Engl J Med , vol.351 , pp. 1513-20
    • Petrylak, D.P.1    Tangen, C.M.2    Mha, H.3
  • 4
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med. 2004;351:1502-12.
    • (2004) N Engl J Med , vol.351 , pp. 1502-12
    • Tannock, I.F.1    De Wit, R.2    Berry, W.R.3
  • 5
    • 33751558449 scopus 로고    scopus 로고
    • Post-therapy changes in PSA as an outcome measure in prostate cancer clinical trials
    • Fleming MT, Morris MJ, Heller G, et al. Post-therapy changes in PSA as an outcome measure in prostate cancer clinical trials. Nat Clin Pract Oncol. 2006;3:658-67.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 658-67
    • Fleming, M.T.1    Morris, M.J.2    Heller, G.3
  • 6
    • 41949104346 scopus 로고    scopus 로고
    • Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
    • Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol. 2008;26:1148-59.
    • (2008) J Clin Oncol , vol.26 , pp. 1148-59
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3    Morris, M.4    Sternberg, C.N.5    Carducci, M.A.6
  • 9
    • 0029873670 scopus 로고    scopus 로고
    • Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer
    • Denmeade SR, Lin XS, Isaacs JT. Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer. Prostate. 1996;28:251-65.
    • (1996) Prostate , vol.28 , pp. 251-65
    • Denmeade, S.R.1    Lin, X.S.2    Isaacs, J.T.3
  • 10
    • 33846603663 scopus 로고    scopus 로고
    • Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
    • Chmelar R, Buchanan G, Need EF, et al. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int J Cancer. 2007;120:719-33.
    • (2007) Int J Cancer , vol.120 , pp. 719-33
    • Chmelar, R.1    Buchanan, G.2    Need, E.F.3
  • 11
    • 34748912386 scopus 로고    scopus 로고
    • Androgen-response elements in hormone refractory prostate cancer: Implications for treatment development
    • Hsieh AC, Small EJ, Ryan CJ. Androgen-response elements in hormone refractory prostate cancer: implications for treatment development. Lancet Oncol. 2007;8:933-9.
    • (2007) Lancet Oncol , vol.8 , pp. 933-9
    • Hsieh, A.C.1    Small, E.J.2    Ryan, C.J.3
  • 12
    • 1842840803 scopus 로고    scopus 로고
    • Hormonal therapy options for patients with a rising prostate specific antigen level after primary treatment for prostate cancer
    • Hellerstedt B. Hormonal therapy options for patients with a rising prostate specific antigen level after primary treatment for prostate cancer. Urology. 2003;62:79-86.
    • (2003) Urology , vol.62 , pp. 79-86
    • Hellerstedt, B.1
  • 13
    • 0030037779 scopus 로고    scopus 로고
    • Activation of two mutant androgen receptors from human prostatic carcinoma by adrenal androgens and metabolic derivatives of testosterone
    • Culig Z, Stober J, Gast A, et al. Activation of two mutant androgen receptors from human prostatic carcinoma by adrenal androgens and metabolic derivatives of testosterone. Cancer Detect Prev. 1996;20:68-75.
    • (1996) Cancer Detect Prev , vol.20 , pp. 68-75
    • Culig, Z.1    Stober, J.2    Gast, A.3
  • 14
    • 8244262043 scopus 로고    scopus 로고
    • Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgendependent human prostate cancer xenograft CWR22 and LNCaP cells
    • Tan J, Sharief Y, Hamil KG, et al. Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgendependent human prostate cancer xenograft CWR22 and LNCaP cells. Mol Endocrinol. 1997;11:450-9.
    • (1997) Mol Endocrinol , vol.11 , pp. 450-9
    • Tan, J.1    Sharief, Y.2    Hamil, K.G.3
  • 15
    • 65549090179 scopus 로고    scopus 로고
    • Diethylstilbestrol (DES) retains activity, is a reasonable option in patients previously treated with docetaxel for castration-resistant prostate cancer
    • Serrate C, Loriot Y, De La Motte Rouge T, et al. Diethylstilbestrol (DES) retains activity, is a reasonable option in patients previously treated with docetaxel for castration-resistant prostate cancer. Ann Oncol. 2009;20:965.
    • (2009) Ann Oncol , vol.20 , pp. 965
    • Serrate, C.1    Loriot, Y.2    De La-Motte-Rouge, T.3
  • 17
    • 65349188286 scopus 로고    scopus 로고
    • Molecular biology of androgen-independent prostate cancer: The role of the androgen receptor pathway
    • Mellado B, Codony J, Ribal MJ, Visa L, Gascon P. Molecular biology of androgen-independent prostate cancer: the role of the androgen receptor pathway. Clin Trans Oncol. 2009;11:5-10.
    • (2009) Clin Trans Oncol , vol.11 , pp. 5-10
    • Mellado, B.1    Codony, J.2    Ribal, M.J.3    Visa, L.4    Gascon, P.5
  • 18
    • 23044504053 scopus 로고    scopus 로고
    • Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    • Freeman MR, Cinar B, Lu ML. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab. 2005;16:273-9.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 273-9
    • Freeman, M.R.1    Cinar, B.2    Lu, M.L.3
  • 19
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgenreceptor signaling axis
    • Scher HI, Sawyers CL. Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgenreceptor signaling axis. J Clin Oncol. 2005;23:8253-61.
    • (2005) J Clin Oncol , vol.23 , pp. 8253-61
    • Scher, H.I.1    Sawyers, C.L.2
  • 20
    • 0035743509 scopus 로고    scopus 로고
    • Molecular biology of the androgen receptor: From molecular understanding to the clinic
    • Eder IE, Culig Z, Putz T, Nessler-Menardi C, Bartsch G, Klocker H. Molecular biology of the androgen receptor: from molecular understanding to the clinic. Eur Urol. 2001;40:241-51.
    • (2001) Eur Urol , vol.40 , pp. 241-51
    • Eder, I.E.1    Culig, Z.2    Putz, T.3    Nessler-Menardi, C.4    Bartsch, G.5    Klocker, H.6
  • 21
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001;1:34-45.
    • (2001) Nat Rev Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 22
    • 4444288439 scopus 로고    scopus 로고
    • Structural and functional consequences of glutamine tract variation in the androgen receptor
    • Buchanan G, Yang M, Cheong A, Harris JM, Irvine RA, Lambert PF, et al. Structural and functional consequences of glutamine tract variation in the androgen receptor. Hum Mol Genet. 2004;13:1677-92.
    • (2004) Hum Mol Genet , vol.13 , pp. 1677-92
    • Buchanan, G.1    Yang, M.2    Cheong, A.3    Harris, J.M.4    Irvine, R.A.5    Lambert, P.F.6
  • 23
    • 0025644325 scopus 로고
    • A mutation in the ligand-binding domain of the androgen receptor of human Lncap cells affects steroid binding characteristics and response to anti-androgens
    • Veldscholte J, Risstalpers C, Kuiper G, Jenster G, Berrevoets C, Claassen E, et al. A mutation in the ligand-binding domain of the androgen receptor of human Lncap cells affects steroid binding characteristics and response to anti-androgens. Biochem Biophys Res Commu. 1990;173:534-40.
    • (1990) Biochem Biophys Res Commu , vol.173 , pp. 534-40
    • Veldscholte, J.1    Risstalpers, C.2    Kuiper, G.3    Jenster, G.4    Berrevoets, C.5    Claassen, E.6
  • 24
    • 0029011116 scopus 로고
    • Mutations of the androgen-receptor gene in metastatic androgen independent prostate cancer
    • Taplin ME, Bubley GJ, Shuster TD, et al. Mutations of the androgen-receptor gene in metastatic androgen independent prostate cancer. N Engl J Med. 1995;332:1393-8.
    • (1995) N Engl J Med , vol.332 , pp. 1393-8
    • Taplin, M.E.1    Bubley, G.J.2    Shuster, T.D.3
  • 25
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm SM, Schmidt LJ, Heemers HV, et al. Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res. 2008;68:5469-77.
    • (2008) Cancer Res , vol.68 , pp. 5469-77
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3
  • 27
    • 36249030631 scopus 로고    scopus 로고
    • Androgen receptor structural and functional elements: Role and regulation in prostate cancer
    • Dehm SM, Tindall DJ. Androgen receptor structural and functional elements: role and regulation in prostate cancer. Mol Endocrinol. 2007;21:2855-63.
    • (2007) Mol Endocrinol , vol.21 , pp. 2855-63
    • Dehm, S.M.1    Tindall, D.J.2
  • 28
    • 1542574202 scopus 로고    scopus 로고
    • Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance
    • Holzbeierlein J, Lal P, LaTulippe E, et al. Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol. 2004;164:217-27.
    • (2004) Am J Pathol , vol.164 , pp. 217-27
    • Holzbeierlein, J.1    Lal, P.2    Latulippe, E.3
  • 31
    • 66649119762 scopus 로고    scopus 로고
    • A Novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin
    • Need EF, Scher HI, Peters AA, Moore NL, Cheong A, Ryan CJ, et al. A Novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin. Endocrinology. 2009;150:2674-82.
    • (2009) Endocrinology , vol.150 , pp. 2674-82
    • Need, E.F.1    Scher, H.I.2    Peters, A.A.3    Moore, N.L.4    Cheong, A.5    Ryan, C.J.6
  • 33
    • 2442528552 scopus 로고    scopus 로고
    • Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-oh kinase in androgen-sensitive epithelial cells
    • Baron S, Manin M, Beaudoin C, Leotoing L, Communal Y, Veyssiere G, et al. Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-oh kinase in androgen-sensitive epithelial cells. J Biol Chem. 2004;279:14579-86.
    • (2004) J Biol Chem , vol.279 , pp. 14579-86
    • Baron, S.1    Manin, M.2    Beaudoin, C.3    Leotoing, L.4    Communal, Y.5    Veyssiere, G.6
  • 34
    • 0034675994 scopus 로고    scopus 로고
    • Steroid-induced androgen receptor-oestradiol receptor beta-src complex triggers prostate cancer cell proliferation
    • Migliaccio A, Castoria G, Di Domenico M, De Falco A, Bilancio A, Lombardi M, et al. Steroid-induced androgen receptor-oestradiol receptor beta-src complex triggers prostate cancer cell proliferation. EMBO J. 2000;19:5406-17.
    • (2000) EMBO J , vol.19 , pp. 5406-17
    • Migliaccio, A.1    Castoria, G.2    Di Domenico, M.3    De Falco, A.4    Bilancio, A.5    Lombardi, M.6
  • 36
    • 65549130575 scopus 로고    scopus 로고
    • Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor
    • Malinowska K, Neuwirt H, Cavarretta IT, Bektic J, Steiner H, Dietrich H, et al. Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. Endocr Relat Cancer. 2009;16:155-69.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 155-69
    • Malinowska, K.1    Neuwirt, H.2    Cavarretta, I.T.3    Bektic, J.4    Steiner, H.5    Dietrich, H.6
  • 38
    • 46949098184 scopus 로고    scopus 로고
    • Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation
    • Seaton A, Scullin P, Maxwell PJ, Wilson C, Pettigrew J, Gallagher R, et al. Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation. Carcinogenesis. 2008;29:1148-56.
    • (2008) Carcinogenesis , vol.29 , pp. 1148-56
    • Seaton, A.1    Scullin, P.2    Maxwell, P.J.3    Wilson, C.4    Pettigrew, J.5    Gallagher, R.6
  • 41
    • 0018558912 scopus 로고
    • Steroid levels in cancer of the prostate-markers of tumor differentiation and adequacy of antiandrogen therapy
    • Geller J, Albert J, Nachtsheim D, Loza D, Lippman S. Steroid levels in cancer of the prostate-markers of tumor differentiation and adequacy of antiandrogen therapy. Prog Clin Biol Res. 1979;33:103-11.
    • (1979) Prog Clin Biol Res , vol.33 , pp. 103-11
    • Geller, J.1    Albert, J.2    Nachtsheim, D.3    Loza, D.4    Lippman, S.5
  • 42
    • 0021334278 scopus 로고
    • Tissue dihydrotestosterone levels and clinical response to hormonal therapy in patients with advanced prostate cancer
    • Geller J, de la Vega DJ, Albert JD, Nachtsheim DA. Tissue dihydrotestosterone levels and clinical response to hormonal therapy in patients with advanced prostate cancer. J Clin Endocrinol Metab. 1984;58:36-40.
    • (1984) J Clin Endocrinol Metab , vol.58 , pp. 36-40
    • Geller, J.1    De La Vega, D.J.2    Albert, J.D.3    Nachtsheim, D.A.4
  • 44
    • 34250331066 scopus 로고    scopus 로고
    • Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer
    • Mostaghel EA, Page ST, Lin DW, Fazli L, Coleman IM, True LD, Knudsen B, Hess DL, Nelson CC, Matsumoto AM, et al. Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007;67: 5033-41.
    • (2007) Cancer Res , vol.67 , pp. 5033-41
    • Mostaghel, E.A.1    Page, S.T.2    Lin, D.W.3    Fazli, L.4    Coleman, I.M.5    True, L.D.6    Knudsen, B.7    Hess, D.L.8    Nelson, C.C.9    Matsumoto, A.M.10
  • 45
    • 8444231965 scopus 로고    scopus 로고
    • The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
    • Nishiyama T, Hashimoto Y, Takahashi K. The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. Clin Cancer Res. 2004;10:7121-6.
    • (2004) Clin Cancer Res , vol.10 , pp. 7121-6
    • Nishiyama, T.1    Hashimoto, Y.2    Takahashi, K.3
  • 49
    • 43849109009 scopus 로고    scopus 로고
    • Satisfaction analysis in men presenting with localized prostate cancer treated with radical prostatectomy or radiotherapy: Psychological and social aspects
    • Gugliotta A, Ferreira U, Reis LO, Matheus WE, Denardi F, Mamprim Stopiglia R, Piccolotto Naccarato AM. Satisfaction analysis in men presenting with localized prostate cancer treated with radical prostatectomy or radiotherapy: psychological and social aspects. Actas Urol Esp. 2008;32:411-6.
    • (2008) Actas Urol Esp , vol.32 , pp. 411-6
    • Gugliotta, A.1    Ferreira, U.2    Reis, L.O.3    Matheus, W.E.4    Denardi, F.5    Mamprim Stopiglia, R.6    Piccolotto-Naccarato, A.M.7
  • 50
    • 4143136459 scopus 로고    scopus 로고
    • Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer
    • Andriole GL, Humphrey P, Ray P, et al. Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer. J Urol. 2004;172:915-9.
    • (2004) J Urol , vol.172 , pp. 915-9
    • Andriole, G.L.1    Humphrey, P.2    Ray, P.3
  • 51
    • 79955148247 scopus 로고    scopus 로고
    • MicroRNAs: A new paradigm on molecular urological oncology
    • Reis LO, Pereira TC, Lopes-Cendes I, Ferreira U. MicroRNAs: a new paradigm on molecular urological oncology. Urology. 2010;76:521-7.
    • (2010) Urology , vol.76 , pp. 521-7
    • Reis, L.O.1    Pereira, T.C.2    Lopes-Cendes, I.3    Ferreira, U.4


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