Additional chromosomal abnormalities detected by array comparative genomic hybridization in AML

Medical Oncology

Volumn 29, Issue 3, 2012, Pages 2083-2087

  Costa, Ana Rosa S ^a   Belangero, Sintia I ^a   Melaragno, Maria Isabel ^a   De Lourdes Chauffaille, Maria ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute myeloid leukemia; Array CGH; Chromosome aberration

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; EVI1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CHROMOSOME 10Q; CHROMOSOME 11P; CHROMOSOME 11Q; CHROMOSOME 14; CHROMOSOME 1P; CHROMOSOME 20Q; CHROMOSOME 22Q; CHROMOSOME 7Q; CHROMOSOME 8; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHROMOSOME DUPLICATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; LEUKEMOGENESIS; MALE; MUTATIONAL ANALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTO ONCOGENE; TRISOMY;

ABNORMAL KARYOTYPE; ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME ABERRATIONS; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84872761849     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-0108-5     Document Type: Article

References (13)

1. Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1, 612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92:2322-33.
2. Mrozek K, Bloomfield CD. Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia. Hematol Am Soc Hematol Educ Program. 2006;169-177.
3. Shinawi M, Cheung SW. The array CGH and its clinical applications. Drug Discov Today. 2008;13:760-70.
4. Maciejewski JP, Mufti GJ. Whole genome scanning as a cytogenetic tool in hematologic malignancies. Blood. 2008;112: 965-74.
5. Shaffer LG, Slovak ML, Campbell LJ, editors. ISCN 2009: an international system for human cytogenetic nomenclature 2009. Basel: S. Karger; 2009.
6. Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C. Detection of large-scale variation in the human genome. Nat Genet. 2004;36:949-51.
7. Andersen MK, Christiansen DH, Kirchhoff M, et al. Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapyrelated MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents. Genes Chromosomes Cancer. 2001;31:33-41.
8. Gao C, Chen YG. Dishevelled: the hub of Wnt signaling. Cell Signal. 2010;22:717-27.
9. Reya T, Clevers H. Wnt signaling in stem cells and cancer. Nature. 2005;434:843-50.
10. Garnis C, Campbell J, Davies JJ, Macaulay C, Lam S, Lam WL. Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis. Hum Mol Genet. 2005;14:475-82.
11. Vasikova A, Budinska E, Belickova M, Cermak J, Bruchova H. Differential gene expression of bone marrow CD34+ cells in early and advanced myelodysplastic syndrome. Neoplasma. 2009;56:335-42.
12. Feuk L, Carson AR, Scherer SW. Structural variation in the human genome. Nat Rev Genet. 2006;7:85-97.
13. Starczynowski DT, Vercauteren S, Sung S, et al. Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leuk Res. 2010;35: 444-7.