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Volumn 31, Issue 1, 2001, Pages 33-41

Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT;

EID: 0035057424     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1115     Document Type: Article
Times cited : (91)

References (38)
  • 6
    • 0002011265 scopus 로고    scopus 로고
    • Gene amplification in human cancer: Biological and clinical significance
    • Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGraw-Hill
    • (1998) , pp. 161-172
    • Brodeur, G.M.1    Hogarty, M.D.2
  • 9
    • 0005273655 scopus 로고    scopus 로고
    • Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Mutations with loss of heterozygosity are common in therapy-related MDS and AML following exposure to alkylating agents, and significantly associated with deletion or loss of 5q, a complex karyotype and a poor prognosis. J Clin Oncol, in press
  • 26
    • 0025949901 scopus 로고
    • Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following cytostatic agents targeting at DNA-topoisomerase II
    • (1991) Blood , vol.78 , pp. 1147-1148
    • Pedersen-Bjergaard, J.1    Philip, P.2
  • 30
    • 0032717039 scopus 로고    scopus 로고
    • The role of chromosome translocations in leukemogenesis
    • (1999) Semin Hematol , vol.36 , Issue.SUPPL. 7 , pp. 59-72
    • Rowley, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.