Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents

Genes Chromosomes and Cancer

Volumn 31, Issue 1, 2001, Pages 33-41

  Andersen, Mette K ^a   Christiansen, Debes H ^a   Kirchhoff, Maria ^a   Pedersen Bjergaard, Jens ^a  

^a Mental Health Services CPH   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOME 11Q; CHROMOSOME ARM; CHROMOSOME BAND; CHROMOSOME DELETION; CHROMOSOME DUPLICATION; CHROMOSOME TRANSLOCATION; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE MUTATION; GENE REARRANGEMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MARKER CHROMOSOME; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; SUPERNUMERARY CHROMOSOME;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; ALKYLATING AGENTS; CHROMOSOME ABERRATIONS; CHROMOSOME BANDING; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 11; CYTOGENETIC ANALYSIS; DNA-BINDING PROTEINS; FEMALE; GENE AMPLIFICATION; GENE DUPLICATION; GENES, P53; HUMANS; LEUKEMIA, MYELOID; MALE; MIDDLE AGED; MUTATION; MYELODYSPLASTIC SYNDROMES; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NUCLEIC ACID HYBRIDIZATION; PROTO-ONCOGENES; RECURRENCE; TRANSCRIPTION FACTORS;

EID: 0035057424     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1115     Document Type: Article

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