Alpha 1-antitrypsin a novel biomarker for obesity in humans

Saudi Medical Journal

Volumn 34, Issue 1, 2013, Pages 34-39

  Xue, Gong B ^a   Zheng, Wen L ^a   Wang, Lei H ^a   Lu, Li Y ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ALPHA 1 ANTITRYPSIN; BIOLOGICAL MARKER; GLUCOSE; INSULIN; LEPTIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; OBESITY;

ALPHA 1-ANTITRYPSIN; BIOLOGICAL MARKERS; BLOOD GLUCOSE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; OBESITY;

EID: 84872741586     PISSN: 03795284     EISSN: 16583175     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Álvarez-Castro P, Sangiao-Alvarellos S, Brandón-Sandá I, Cordido F. Endocrine function in obesity. Función endocrina en la obesidad. Endocrinol Nutr 2011; 58: 422-432.
2. Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006; 393 (Pt 1): 7-20.
3. Schwetz V, Pieber T, Obermayer-Pietsch B. Te endocrine role of the skeleton: background and clinical evidence. Eur J Endocrinol 2012; 166: 959-967.
4. Alikaşifoǧlu A, Gönç N, Özön ZA, Sen Y, Kandemir N. Te Relationship Between Serum Adiponectin, Tumor Necrosis Factor-Alpha, Leptin Levels and Insulin Sensitivity in Childhood and Adolescent Obesity:Adiponectin is a Marker of Metabolic Syndrome. J Clin Res Pediatr Endocrinol 2009; 1: 233-239.
5. Lucassen EA, Rother KI, Cizza G. Interacting epidemics? Sleep curtailment, insulin resistance, and obesity. Ann N Y Acad Sci 2012; 1264: 110-134.
6. El-Abhar HH, Schaalan MF. Topiramate-Induced Modulation of Hepatic Molecular Mechanisms: An Aspect for Its Anti- Insulin Resistant Efect. PloS ONE 2012; 5: 1-9.
7. Lazrak A, Nita I, Subramaniyam D, Wei S, Song W, Ji HL, Janciauskiene S, Matalon S. Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo. Am J Respir Cell Mol Biol 2009; 41: 261-270.
8. Schmechel DE, Edwards CL. Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent. Neurotoxicology 2012; 33: 1454-1472.
9. Yang M, Sun J, Zhang T, Liu J, Zhang J, Shi MA, et al. Defciency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice. Arterioscler Tromb Vasc Biol 2008; 28: 2202-2208.
10. Funicello M, Novelli M, Ragni M, Vottari T, Cocuzza C, Soriano-Lopez J, et al. Cathepsin K Null Mice Show Reduced Adiposity during the Rapid Accumulation of Fat Stores. PLoS One 2007; 2: e683.
11. Pupek-Musialik D, Musialik K, Hen K. Obesity-a challenge for modern ortopedy. Chir Narzadow Ruchu Ortop Pol 2010; 75: 236-241.
12. Jin H, Meyer JM, Mudaliar S, Jeste DV. Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin. Schizophr Res 2008; 100: 70-85.
13. Hillon P, Guiu B, Vincent J, Petit JM. Obesity, type 2 diabetes and risk of digestive cancer. Gastroenterol Clin Biol 2010; 34: 529-533.
14. Ebbeling CB, Swain JF, Feldman HA, Wong WW, Hachey DL, Garcia-Lago E, Ludwig DS.Efects of dietary composition on energy expenditure during weight-loss maintenance. JAMA 2012; 307: 2627-2634.
15. Olokoba AB, Obateru OA, Olokoba LB. Type 2 diabetes mellitus: a review of current trends. Oman Med J 2012; 27: 269-273.
16. Rahman SM, Qadri I, Janssen RC, Friedman JE. Fenofbrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus- induced steatosis. J Lipid Res 2009; 50: 2193-202.
17. Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring) 2010; 18: 780-787.
18. Fregonese L, Stolk J. Hereditary alpha-1-antitrypsin defciency and its clinical consequences. Orphanet J Rare Dis 2008; 3: 16.
19. Tuder RM, Janciauskiene SM, Petrache I. Lung disease associated with alpha1-antitrypsin defciency. Proc Am Torac Soc 2010; 7: 381-386.
20. Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 2005; 102: 10610-10615.
21. Cinar N, Gülçelik NE, Aydín K, Akín S, Usman A, Gürlek A. Serum vaspin levels in hypothyroid patients. Eur J Endocrinol 2011; 165: 563-569.