Icariin and its emerging role in the treatment of osteoporosis

Chinese Medical Journal

Volumn 126, Issue 2, 2013, Pages 400-

  Kapoor, Shailendra ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; AGGRECAN; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; GENISTEIN; ICARIIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR SOX9;

BONE MATURATION; BONE REGENERATION; CARTILAGE CELL; CELL DIFFERENTIATION; CHONDROGENESIS; COLLAGEN SYNTHESIS; DISTRACTION OSTEOGENESIS; EXTRACELLULAR MATRIX; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; LETTER; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM;

EID: 84872706203     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20122380     Document Type: Letter

References (7)

1. Liu M, Zhong C, He RX, Chen LF. Icariin associated with exercise therapy is an effective treatment for postmenopausal osteoporosis. Chin Med J 2012; 125: 1784-1789.
2. Liang W, Lin M, Li X, Li C, Gao B, Gan H, et al. Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line. Int J Mol Med 2012; Epub ahead of print.
3. Ming LG, Chen KM, Xian CJ. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling. J Cell Physiol 2012; in press.
4. Zheng D, Peng S, Yang SH, Shao ZW, Yang C, Feng Y, et al. The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice. Bone 2012; 51: 85-92.
5. Fan JJ, Cao LG, Wu T, Wang DX, Jin D, Jiang S, et al. The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells. Molecules 2011; 16: 10123-10133.
6. Zhang DW, Zhang JC, Fong CC, Yao XS, Yang MS. Herba epimedii flavonoids suppress osteoclastic differentiation and bone resorption by inducing G2/M arrest and apoptosis. Biochimie 2012; 94: 2514-2522.
7. Zhang L, Zhang X, Li KF, Li XD, Xiao YM, Fan YJ, et al. Icariin promotes extracellular matrix synthesis and gene expression of chondrocytes in vitro. Phytother Res 2012; Epub ahead of print.