메뉴 건너뛰기




Volumn 5, Issue 3, 2013, Pages 1068-1074

The hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells

Author keywords

4 methylumbelliferone; Apoptosis; Canine mammary tumor; Chemokinesis; Chemotaxis; Hyaluronan; Hyaluronan synthase

Indexed keywords

HYALURONIC ACID; HYMECROMONE; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; PROTEIN BAX; UVOMORULIN; VIMENTIN;

EID: 84872699887     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1124     Document Type: Article
Times cited : (36)

References (36)
  • 1
    • 2142650671 scopus 로고
    • Isolation of the aldobionic acid of umbilical cord hyaluronic acid
    • Weismann B, Rapport MM, Linker A and Meyer K: Isolation of the aldobionic acid of umbilical cord hyaluronic acid. J Biol Chem 205: 205-221, 1953.
    • (1953) J Biol Chem , vol.205 , pp. 205-221
    • Weismann, B.1    Rapport, M.M.2    Linker, A.3    Meyer, K.4
  • 2
    • 3042697038 scopus 로고    scopus 로고
    • Hyaluronan: From extracellular glue to pericellular cue
    • Toole BP: Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 4: 528-539, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 528-539
    • Toole, B.P.1
  • 3
    • 0027504082 scopus 로고
    • Hyaluronan-binding proteins in development, tissue homeostasis, and disease
    • Knudson CB and Knudson W: Hyaluronan-binding proteins in development, tissue homeostasis, and disease. FASEB J 7: 1233-1241, 1993.
    • (1993) FASEB J , vol.7 , pp. 1233-1241
    • Knudson, C.B.1    Knudson, W.2
  • 4
    • 0033889231 scopus 로고    scopus 로고
    • Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival
    • Auvinen P, Tammi R, Parkkinen J, et al: Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am J Pathol 156: 529-536, 2000.
    • (2000) Am J Pathol , vol.156 , pp. 529-536
    • Auvinen, P.1    Tammi, R.2    Parkkinen, J.3
  • 5
    • 44749087178 scopus 로고    scopus 로고
    • Altered hyaluronan biosynthesis in cancer progression
    • Itano N and Kimata K: Altered hyaluronan biosynthesis in cancer progression. Semin Cancer Biol 18: 268-274, 2008.
    • (2008) Semin Cancer Biol , vol.18 , pp. 268-274
    • Itano, N.1    Kimata, K.2
  • 6
    • 22244442728 scopus 로고    scopus 로고
    • Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer
    • Udabage L, Brownlee GR, Waltham M, et al: Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Cancer Res 65: 6139-6150, 2005.
    • (2005) Cancer Res , vol.65 , pp. 6139-6150
    • Udabage, L.1    Brownlee, G.R.2    Waltham, M.3
  • 7
    • 25844473391 scopus 로고    scopus 로고
    • The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer
    • Udabage L, Brownlee GR, Nilsson SK and Brown TJ: The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer. Exp Cell Res 310: 205-217, 2005.
    • (2005) Exp Cell Res , vol.310 , pp. 205-217
    • Udabage, L.1    Brownlee, G.R.2    Nilsson, S.K.3    Brown, T.J.4
  • 8
    • 34247492506 scopus 로고    scopus 로고
    • Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells
    • Li Y, Li L, Brown TJ and Heldin P: Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells. Int J Cancer 120: 2557-2567, 2007.
    • (2007) Int J Cancer , vol.120 , pp. 2557-2567
    • Li, Y.1    Li, L.2    Brown, T.J.3    Heldin, P.4
  • 10
    • 4043180585 scopus 로고    scopus 로고
    • A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-Methylumbelliferone
    • Kakizaki I, Kojima K, Takagaki K, et al: A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-Methylumbelliferone. J Biol Chem 279: 33281-33289, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 33281-33289
    • Kakizaki, I.1    Kojima, K.2    Takagaki, K.3
  • 11
    • 67349260101 scopus 로고    scopus 로고
    • 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
    • Kultti A, Pasonen-Seppänen S, Jauhiainen M, et al: 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. Exp Cell Res 315: 1914-1923, 2009.
    • (2009) Exp Cell Res , vol.315 , pp. 1914-1923
    • Kultti, A.1    Pasonen-Seppänen, S.2    Jauhiainen, M.3
  • 12
    • 77950845327 scopus 로고    scopus 로고
    • Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells
    • Lokeshwar VB, Lopez LE, Munoz D, et al: Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells. Cancer Res 70: 2613-2623, 2010.
    • (2010) Cancer Res , vol.70 , pp. 2613-2623
    • Lokeshwar, V.B.1    Lopez, L.E.2    Munoz, D.3
  • 13
    • 18144391946 scopus 로고    scopus 로고
    • A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
    • Yoshihara S, Kon A, Kudo D, et al: A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS Lett 579: 2722-2726, 2005.
    • (2005) FEBS Lett , vol.579 , pp. 2722-2726
    • Yoshihara, S.1    Kon, A.2    Kudo, D.3
  • 14
    • 84856016321 scopus 로고    scopus 로고
    • Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
    • Arai E, Nishida Y, Wasa J, et al: Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo. Brit J Cancer 105: 1839-1849, 2011.
    • (2011) Brit J Cancer , vol.105 , pp. 1839-1849
    • Arai, E.1    Nishida, Y.2    Wasa, J.3
  • 15
    • 83655167411 scopus 로고    scopus 로고
    • Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo
    • Urakawa H, Nishida Y, Wasa J, et al: Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo. Int J Cancer 130: 454-466, 2012.
    • (2012) Int J Cancer , vol.130 , pp. 454-466
    • Urakawa, H.1    Nishida, Y.2    Wasa, J.3
  • 16
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 18
    • 37549053307 scopus 로고    scopus 로고
    • Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling
    • Shintani Y, Maeda M, Chaika N, Johnson KR and WheelockMJ: Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol 38: 95-104, 2008.
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 95-104
    • Shintani, Y.1    Maeda, M.2    Chaika, N.3    Johnson, K.R.4    Wheelock, M.J.5
  • 19
    • 0242412978 scopus 로고    scopus 로고
    • Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells
    • Zoltan-Jones A, Huang L, Ghatak S and Toole BP: Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. J Biol Chem 278: 45801-45810, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 45801-45810
    • Zoltan-Jones, A.1    Huang, L.2    Ghatak, S.3    Toole, B.P.4
  • 20
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metast Rev 28: 15-33, 2009.
    • (2009) Cancer Metast Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 21
    • 0033192859 scopus 로고    scopus 로고
    • Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in beagles
    • Benjamin SA, Lee AC and Saunders WJ: Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in beagles. Vet Pathol 36: 423-436, 1999.
    • (1999) Vet Pathol , vol.36 , pp. 423-436
    • Benjamin, S.A.1    Lee, A.C.2    Saunders, W.J.3
  • 23
    • 65249091846 scopus 로고    scopus 로고
    • Comparative expression pathways analysis of human and canine mammary tumors
    • Uva P, Aurisicchio L, Watters J, et al: Comparative expression pathways analysis of human and canine mammary tumors. BMC Genomics 10: 135, 2009.
    • (2009) BMC Genomics , vol.10 , pp. 135
    • Uva, P.1    Aurisicchio, L.2    Watters, J.3
  • 24
  • 25
    • 80053207343 scopus 로고    scopus 로고
    • Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane
    • Saito T, Kawana H, Azuma K, Toyoda A, Kitagawa M and Harigaya K: Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane. Int J Oncol 39: 1311-1320, 2011.
    • (2011) Int J Oncol , vol.39 , pp. 1311-1320
    • Saito, T.1    Kawana, H.2    Azuma, K.3    Toyoda, A.4    Kitagawa, M.5    Harigaya, K.6
  • 26
    • 78650847291 scopus 로고    scopus 로고
    • Overexpression of human ortholog of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in human breast cancers
    • Toyoda A, Yokota A, Saito T, et al: Overexpression of human ortholog of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in human breast cancers. Int J Oncol 38: 89-96, 2011.
    • (2011) Int J Oncol , vol.38 , pp. 89-96
    • Toyoda, A.1    Yokota, A.2    Saito, T.3
  • 27
    • 33749024777 scopus 로고    scopus 로고
    • Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    • Christiansen JJ and Rajasekaran AK: Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 66: 8319-8326, 2006.
    • (2006) Cancer Res , vol.66 , pp. 8319-8326
    • Christiansen, J.J.1    Rajasekaran, A.K.2
  • 28
    • 0034690807 scopus 로고    scopus 로고
    • Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine
    • Xia W, Spector S, Hardly L, Zhao S, Saluk A, Alemane L and Spector NL: Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine. Proc Natl Acad Sci USA 97: 7494-7499, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7494-7499
    • Xia, W.1    Spector, S.2    Hardly, L.3    Zhao, S.4    Saluk, A.5    Alemane, L.6    Spector, N.L.7
  • 29
    • 0030761980 scopus 로고    scopus 로고
    • Purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells: Identification as an NH2-terminal fragments of human fibronectin
    • Hu M, Pollock RE and Nicolson GL: Purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells: identification as an NH2-terminal fragments of human fibronectin. Cancer Res 57: 3577-3584, 1997.
    • (1997) Cancer Res , vol.57 , pp. 3577-3584
    • Hu, M.1    Pollock, R.E.2    Nicolson, G.L.3
  • 31
    • 0035045589 scopus 로고    scopus 로고
    • High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer
    • Lipponen P, Aaltomaa S, Tammi R, Tammi M, Agren U and Kosma VM: High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer. Eur J Cancer 37: 849-856, 2001.
    • (2001) Eur J Cancer , vol.37 , pp. 849-856
    • Lipponen, P.1    Aaltomaa, S.2    Tammi, R.3    Tammi, M.4    Agren, U.5    Kosma, V.M.6
  • 32
  • 33
    • 0030783518 scopus 로고    scopus 로고
    • Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation
    • Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L and HungMC: Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation. J Biol Chem 272: 27913-27918, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 27913-27918
    • Bourguignon, L.Y.1    Zhu, H.2    Chu, A.3    Iida, N.4    Zhang, L.5    Hung, M.C.6
  • 34
    • 38349026544 scopus 로고    scopus 로고
    • In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver
    • Ouhit A, Abd Elmageed ZY, Abdraboh ME, Lioe TF and RajMH: In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver. Am J Pathol 171: 2033-2039, 2007.
    • (2007) Am J Pathol , vol.171 , pp. 2033-2039
    • Ouhit, A.1    Abd Elmageed, Z.Y.2    Abdraboh, M.E.3    Lioe, T.F.4    Raj, M.H.5
  • 35
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE and Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.