Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials

Molecular Pharmacology

Volumn 83, Issue 2, 2013, Pages 406-415

  Desaphy, Jean François ^a   Carbonara, Roberta ^a   Costanza, Teresa ^a   Lentini, Giovanni ^a   Cavalluzzi, Maria Maddalena ^a   Bruno, Claudio ^a   Franchini, Carlo ^a   Camerino, Diana Conte ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LUBELUZOLE; RILUZOLE; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CELL STRAIN HEK293; CHRONIC PAIN; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DOSE RESPONSE; DRUG EFFICACY; HUMAN; HUMAN CELL; IC 50; ISOMER; MOLECULAR INTERACTION; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RACEMIC MIXTURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANESTHETICS, LOCAL; BINDING SITES; CELL LINE; HEK293 CELLS; HUMANS; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MUTATION; NAV1.4 VOLTAGE-GATED SODIUM CHANNEL; NEUROPROTECTIVE AGENTS; PIPERIDINES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN ISOFORMS; RILUZOLE; SODIUM CHANNEL BLOCKERS; THIAZOLES;

EID: 84872697428     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.080804     Document Type: Article

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