ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936

Behavior Genetics

Volumn 43, Issue 1, 2013, Pages 13-23

  Lyall, Donald M ^a   Lopez, Lorna M ^a   Bastin, Mark E ^a   Maniega, Susana Muñoz ^a   Penke, Lars ^a   Valdés Hernández, Maria Del C ^a   Royle, Natalie A ^a   Starr, John M ^a,b   Porteous, David J ^a   Wardlaw, Joanna M ^a   Deary, Ian J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

ADRB2; Cognitive ageing; Diffusion MRI; Intelligence; Processing speed; Tractography; White matter

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 3;

ADRB2 GENE; ADULT; AGED; AGING; ARCUATE FASCICULUS; ARTICLE; BIRTH; COGNITION; COHORT ANALYSIS; DIFFUSION TENSOR IMAGING; EXPLORATORY RESEARCH; FUNCTIONAL ASSESSMENT; GENETIC VARIABILITY; HUMAN; MENTAL CAPACITY; MENTAL PERFORMANCE; PHENOTYPE; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; WHITE MATTER;

AGED; AGING; ALLELES; BRAIN; COGNITION; COGNITION DISORDERS; COHORT STUDIES; DIFFUSION MAGNETIC RESONANCE IMAGING; FALSE POSITIVE REACTIONS; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MUTATION; NERVE FIBERS, MYELINATED; PHENOTYPE; RECEPTORS, ADRENERGIC, BETA-2; SCOTLAND;

EID: 84872681871     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-012-9570-x     Document Type: Article

References (39)

1. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265
2. Behrens TEJ, Berg HJ, Jbabdi R, Rushworth MFS, Woolrich WM (2007) Probabilistic diffusion tractography with multiple fibre orientations: what can we gain? Neuroimage 34:144-155
3. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc 57:289-300
4. Bochdanovits Z, Gosso FM, van den Berg L, Rizzu P, Polderman TJC, Pardo LM, Houlihan LM et al (2009) A functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly. Behav Genet 39:15-23
5. Brodde OE (2008) Beta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases. Fundam Clin Pharm 22:107-125
6. Cagliani R, Fumagalli M, Pozzoli U, Riva S, Comi GP, Torri F, Macciardi F (2009) Diverse evolutionary histories for β-adrenoreceptor genes in humans. Am J Hum Gen 85:64-75
7. Cheslack-Postova K, Fallin MD, Avramopoulos D, Connors SL, Zimmerman AW, Eberhart CG, Newschaffer CJ (2007) β2-Adrenergic receptor gene variants and risk for autism in the AGRE cohort. Mol Psychiatry 12:283-291
8. Clayden JD, Storkey AJ, Bastin ME (2007) A probabilistic model-based approach to consistent white matter tract segmentation. IEEE Trans Med Imag 26:1555-1561
9. Clayden JD, Munoz Maniega S, Storkey AJ, King MD, Bastin ME, Clark CA (2011) TractoR: magnetic resonance imaging and tractography with R. J Stat Softw 44:1-18
10. Cox BD, Huppert FA, Whichelow MJ (1993) The health and lifestyle survey: seven years on. Dartmouth, Aldershot
11. Deary IJ, Gow AJ, Taylor MD, Corley J, Brett C, Wilson V et al (2007) The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr 7:1-12
12. Deary IJ, Corley J, Gow AJ, Harris SE, Houlihan LM, Marioni RE, Penke L et al (2009) Age-associated cognitive decline. Br Med Bull 92:135-152
13. Deary IJ, Penke L, Johnson W (2010) The neuroscience of human intelligence differences. Nat Rev Neurosci 11:201-211
14. Deary IJ, Gow AJ, Pattie A, Starr JM (2011) Cohort profile: the Lothian Birth Cohorts of 1921 and 1936. Int J Epidemiol. doi: 10.1093/ije/dyr197
15. Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ (1991) Model systems for the study of seven-transmembrane-segment receptors. Ann Rev Biochem 60:653-688
16. Efron B, Tibshirani TJ (1993) An introduction to the bootstrap. Chapman & Hall, New York
17. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
18. Fritz MS, MacKinnon DP (2007) Required sample size to detect the mediated effect. Psychol Sci 18:233-239
19. Houlihan LM, Wyatt ND, Harris SE, Hayward C, Gow AJ, Marioni RE, Strachan MWJ et al (2010) Variation in the uric acid transporter gene (SLC2A9) and memory performance. Hum Mol Gen 19:2321-2330
20. Jung RE, Haier RJ (2007) The Parieto-Frontal integration theory (P-FIT) of intelligence: converging neuroimaging evidence. Behav Brain Sci 30:135-187
21. Lezak MD, Howieson DB, Loring DW (2004) Neuropsychological assessment, 4th edn. Oxford University Press, Oxford
22. Lopez LM, Bastin ME, Maniega SM, Penke L, Davies G, Christoforou A, Hernandez MCV et al (2012) A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity. Neurobiol Ageing. doi: 10.1016/j.neurobiolaging.2012.02.003
23. Luciano M, Gow AJ, Harris SE, Hayward C, Allerhand M, Starr JM, Visscher PM et al (2009) Cognitive ability at age 11 and 70 years, information processing speed, and APOE variation: the Lothian Birth Cohort 1936 study. Psychol Aging 24:129-138
24. MacKinnon DP, Krull JL, Lockwood CH (2000) Equivalence of the mediation, confounding and suppression effect. Prev Sci 1:173-186
25. Nyholt DR (2001) Genetic case-control association studies: correcting for multiple testing. Hum Genet 109:564-565
26. Penke L, Maniega SM, Houlihan LM, Murray C, Gow AJ, Clayden JD, Bastin ME et al (2010a) White matter integrity in splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2. Behav Genet 40:146-156
27. Penke L, Maniega SM, Murray C, Gow AJ, Hernandez MCV, Clayden JD, Starr JM et al (2010b) A general factor of brain white matter integrity predicts information processing speed in healthy older people. J Neurosci 30:7569-7574
28. Penke L, Maniega SM, Bastin ME, Valdés Hernández MC, Murray C, Royle NA, Starr JM et al (2012) Brain white matter tract integrity as a neural foundation for general intelligence. Mol Psychiatry 17:1026-1030
29. Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G (1996) Diffusion tensor MR imaging of the human brain. Radiology 201:637-648
30. Pike N (2011) Using false discovery rates for multiple comparisons in ecology and evolution. Methods Ecol Evol 2:278-282
31. Preacher KJ, Hayes AF (2008) Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 30:879-891
32. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D, Maller J et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analysis. Am J Hum Genet 81:559-575
33. Salthouse T (2010) Mediators and moderators of cognitive aging. In: Salthouse T (ed) Major issues in cognitive aging. OUP, Oxford, pp 98-126
34. Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK (2005) Cognitive functions correlate with white matter architecture in a normal paediatric population: a diffusion tensor MR imaging study. Hum Brain Mapp 26:139-147
35. Snieder H, Dong Y, Barbaeu P, Harshfield GA, Dalageogou C, Zhu H, Carter ND et al (2002) β2-adrenergic receptor gene and resting hemodynamics in European and African American youth. AJH 15:973-979
36. Wardlaw J, Bastin M, Hernandez V, Munoz Maniega S, Royle N, Morris Z, Clayden J et al (2011) Brain ageing, cognition in youth and old age, and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol. Int J Stroke 6:547-559
37. Wechsler D (1998a) Wechsler adult intelligence scale-III UK administration and scoring manual. Psychological Corporation, London
38. Wechsler D (1998b) Wechsler memory scale-III UK administration and scoring manual. Psychological Corporation, London
39. Williams SC, Haines JL (2011) Correcting away the hidden heritability. Ann Human Genet 75:348-350