Role of local insulin augmentation upon allograft incorporation in a rat femoral defect model

Journal of Orthopaedic Research

Volumn 29, Issue 1, 2011, Pages 92-99

  Dedania, Jemin ^a   Borzio, Robert ^a   Paglia, David ^a   Breitbart, Eric A ^a   Mitchell, Ashley ^a   Vaidya, Swaroopa ^a   Wey, Aaron ^a   Mehta, Siddhant ^a   Benevenia, Joseph ^a   O'Connor, J Patrick ^a   Lin, Sheldon S ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

allograft; defect; insulin; non union

Indexed keywords

INSULIN;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GRAFT; BONE GROWTH; CONTROLLED STUDY; DONOR SITE; DRUG EFFECT; FEMUR FRACTURE; FRACTURE FIXATION; FRACTURE HEALING; HISTOLOGY; MICRORADIOGRAPHY; MORBIDITY; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SCORING SYSTEM;

ANIMALS; BONE TRANSPLANTATION; FEMUR; INSULIN; MODELS, ANIMAL; OSTEOGENESIS; RATS; RATS, INBRED BB; TRANSPLANTATION, HOMOLOGOUS;

EID: 78649538907     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21205     Document Type: Article

References (34)

1. Schwartz CE, Martha JF, Kowalski P, et al. 2009. Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome. Health Qual Life Outcomes 7: 49.
2. Dimitriou R, Tsiridis E, Giannoudis PV,. 2005. Current concepts of molecular aspects of bone healing. Injury 36: 1392-1404.
3. Joyce ME, Jingushi S, Scully SP, et al. 1991. Role of growth factors in fracture healing. Prog Clin Biol Res 365: 391-416.
4. Linkhart TA, Mohan S, Baylink DJ,. 1996. Growth factors for bone growth and repair: IGF, TGF beta and BMP. Bone 19 (1 Suppl): 1S-12S.
5. Hickman J, McElduff A,. 1989. Insulin promotes growth of the cultured rat osteosarcoma cell line UMR-106-01: an osteoblast-like cell. Endocrinology 124: 701-706.
6. Levy JR, Murray E, Manolagas S, et al. 1986. Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Endocrinology 119: 1786-1792.
7. Kream BE, Smith MD, Canalis E, et al. 1985. Characterization of the effect of insulin on collagen synthesis in fetal rat bone. Endocrinology 116: 296-302.
8. Gabbitas B, Pash J, Canalis E,. 1994. Regulation of insulin-like growth factor-II synthesis in bone cell cultures by skeletal growth factors. Endocrinology 135: 284-289.
9. Machwate M, Zerath E, Holy X, et al. 1994. Insulin-like growth factor-I increases trabecular bone formation and osteoblastic cell proliferation in unloaded rats. Endocrinology 134: 1031-1038.
10. Stuck WG,. 1932. The effect of insulin on the healing of experimental fractures in the rabbit. J Bone Joint Surg 14: 109.
11. Cornish J, Callon KE, Reid IR,. 1996. Insulin increases histomorphometric indices of bone formation in vivo. Calcif Tissue Int 59: 492-495.
12. Einhorn TA, Boskey AL, Gundberg CM, et al. 1988. The mineral and mechanical properties of bone in chronic experimental diabetes. J Orthop Res 6: 317-323.
13. Puche RC, Romano MC, Locatto ME, et al. 1973. The effect of insulin on bone resorption. Calcif Tissue Res 12: 8-15.
14. Chen X, Kidder LS, Lew WD,. 2002. Osteogenic protein-1 induced bone formation in an infected segmental defect in the rat femur. J Orthop Res 20: 142-150.
15. Einhorn TA, Lane JM, Burstein AH, et al. 1984. The healing of segmental bone defects induced by demineralized bone matrix. A radiographic and biomechanical study. J Bone Joint Surg Am 66: 274-279.
16. Feighan JE, Davy D, Prewett AB, et al. 1995. Induction of bone by a demineralized bone matrix gel: a study in a rat femoral defect model. J Orthop Res 13: 881-891.
17. Hunt TR, Schwappach JR, Anderson HC,. 1996. Healing of a segmental defect in the rat femur with use of an extract from a cultured human osteosarcoma cell-line (Saos-2). A preliminary report. J Bone Joint Surg Am 78: 41-48.
18. Nottebaert M, Lane JM, Juhn A, et al. 1989. Omental angiogenic lipid fraction and bone repair. An experimental study in the rat. J Orthop Res 7: 157-169.
19. Azad V, Breitbart E, Al-Zube L, et al. 2009. rhBMP-2 enhances the bone healing response in a diabetic segmental defect model. J Orthop Trauma 23: 267-276.
20. Koenig RJ, Peterson CM, Jones RL, et al. 1976. Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus. N Engl J Med 295: 417-420.
21. Breitbart EA, Meade S, Azad V, et al. 2010. Mesenchymal stem cells accelerate bone allograft incorporation in the presence of diabetes mellitus. J Orthop Res 28: 942-949.
22. Harten RD, Jr., Lee FY, Zimmerman MC, et al. 1997. Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing. J Orthop Res 15: 570-576.
23. Seeherman HJ, Bouxsein M, Kim H, et al. 2004. Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model. J Bone Joint Surg Am 86-A: 1961-1972.
24. Beam HA, Parsons JR, Lin SS,. 2002. The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus. J Orthop Res 20: 1210-1216.
25. Follak N, Kloting I, Merk H,. 2005. Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats. Diabetes Metab Res Rev 21: 288-296. (Pubitemid 40716162)
26. Funk JR, Hale JE, Carmines D, et al. 2000. Biomechanical evaluation of early fracture healing in normal and diabetic rats. J Orthop Res 18: 126-132.
27. Gandhi A, Beam HA, O'Connor JP, et al. 2005. The effects of local insulin delivery on diabetic fracture healing. Bone 37: 482-490.
28. Macey LR, Kana SM, Jingushi S, et al. 1989. Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am 71: 722-733.
29. Zhang X, Xie C, Lin AS, et al. 2005. Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res 20: 2124-2137.
30. Shimoaka T, Kamekura S, Chikuda H, et al. 2004. Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem 279: 15314-15322.
31. Lu H, Kraut D, Gerstenfeld LC, et al. 2003. Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology 144: 346-352.
32. Kawaguchi H, Kurokawa T, Hanada K, et al. 1994. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Endocrinology 135: 774-781.
33. Tyndall WA, Beam HA, Zarro C, et al. 2003 Decreased platelet derived growth factor expression during fracture healing in diabetic animals. Clin Orthop 408: 319-330.
34. Harten RD, Svach DJ, Schmeltzer R, et al. 2005 Salicyclic acid-derived poly(anhydride-esters) inhibit bone resorption and formation in vivo. J Biomed Mater Res A 72: 354-362.