Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 497-502

  Sashidhara, Koneni V ^a   Singh, Suriya P ^a   Singh, Shiv Vardan ^a   Srivastava, Rajeev K ^a   Srivastava, Kumkum ^a   Saxena, J K ^a   Puri, Sunil K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Hematin; Antiplasmodial; Flacourtia indica; Hydrogen peroxide mediated hemin degradation; Phenolic glycoside; Phenylpropanoid catechin

Indexed keywords

2 (2 BENZOYL BETA DEXTRO GLUCOPYRANOSYLOXY) 7 (1ALPHA,2ALPHA,6ALPHA TRIHYDROXY 3 OXOCYCLOHEX 4 ENOYL) 5 HYDROXYBENZYL ALCOHOL; ANTIMALARIAL AGENT; BETA HEMATIN; CATECHIN [5,6] 4BETA (3,4 DIHYDROXYPHENYL)DIHYDRO 2(3H) PYRANONE; CHLOROQUINE; HEME DERIVATIVE; HEMIN; MURURIN A; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; IC 50; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION; PROTEIN DEGRADATION; VERO CELL;

ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLACOURTIACEAE; GLYCOSIDES; HEMEPROTEINS; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; PHENOLS; PLANT LEAVES; PLANT STEMS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872677600     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.019     Document Type: Article

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