ARK5 promotes glioma cell invasion, and its elevated expression is correlated with poor clinical outcome

European Journal of Cancer

Volumn 49, Issue 3, 2013, Pages 752-763

  Lu, Shijun ^a   Niu, Na ^a   Guo, Hua ^b   Tang, Jinbao ^a   Guo, Wenjun ^a   Liu, Zhijun ^a   Shi, Lihong ^a   Sun, Tongyi ^a   Zhou, Fenghua ^a   Li, Hongli ^a   Zhang, Jin ^a   Zhang, Baogang ^a  

^a WEIFANG MEDICAL UNIVERSITY   (China)

^b KEY LABORATORY OF CANCER PREVENTION AND THERAPY   (China)

Author keywords

ARK5; Biomarker; Cytoskeleton; MMP; Molecular mechanisms

Indexed keywords

ARK5 PROTEIN; GELATINASE A; GELATINASE B; LIM KINASE 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER PROGNOSIS; CANCER SURVIVAL; CYTOSKELETON; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING;

ACTINS; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; DISEASE PROGRESSION; FEMALE; GLIOMA; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIM KINASES; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; PROTEIN KINASES; REPRESSOR PROTEINS;

EID: 84872677092     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2012.09.018     Document Type: Article

References (46)

1. A. Rousseau, K. Mokhtari, and C. Duyckaerts The 2007 WHO classification of tumors of the central nervous system-what has changed? Curr Opin Neurol 21 6 2008 720 727
2. T. Demuth, and M.E. Berens Molecular mechanisms of glioma cell migration and invasion J Neurooncol 70 2 2004 217 228
3. A.J. Gabayan, S.B. Green, and A. Sanan GliaSite brachytherapy for treatment of recurrent malignant gliomas: a retrospective multi-institutional analysis Neurosurgery 58 4 2006 701 709 [discussion 701-9]
4. F.B. Furnari, T. Fenton, and R.M. Bachoo Malignant astrocytic glioma: genetics, biology, and paths to treatment Genes Dev 21 21 2007 2683 2710
5. J.P. Steinbach, A. Klumpp, H. Wolburg, and M. Weller Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death Cancer Res 64 5 2004 1575 1578
6. L.A. Stewart Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials Lancet 359 9311 2002 1011 1018
7. G. Das, A. Shiras, K. Shanmuganandam, and P. Shastry Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells Mol Carcinog 50 6 2011 412 423
8. P.A. Forsyth, H. Wong, and T.D. Laing Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas Br J Cancer 79 11-12 1999 1828 1835
9. D. Stapleton, K.I. Mitchelhill, and G. Gao Mammalian AMP-activated protein kinase subfamily J Biol Chem 271 2 1996 611 614
10. A. Suzuki, G. Kusakai, and A. Kishimoto Regulation of caspase-6 and FLIP by the AMPK family member ARK5 Oncogene 23 42 2004 7067 7075
11. A. Suzuki, S. Iida, and M. Kato-Uranishi ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma Oncogene 24 46 2005 6936 6944
12. A. Suzuki, G. Kusakai, and A. Kishimoto Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein J Biol Chem 278 1 2003 48 53
13. A. Suzuki, G. Kusakai, A. Kishimoto, J. Lu, T. Ogura, and H. Esumi ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation Oncogene 22 40 2003 6177 6182
14. A. Suzuki, G. Kusakai, and Y. Shimojo Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation J Biol Chem 280 36 2005 31557 31563
15. A. Suzuki, T. Ogura, and H. Esumi NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling J Biol Chem 281 20 2006 13915 13921
16. B. Zhang, F. Gu, and C. She Reduction of Akt2 inhibits migration and invasion of glioma cells Int J Cancer 125 3 2009 585 595
17. M.J. Arboleda, J.F. Lyons, and F.F. Kabbinavar Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells Cancer Res 63 1 2003 196 206
18. S.J. Grille, A. Bellacosa, and J. Upson The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines Cancer Res 63 9 2003 2172 2178
19. B.K. Park, X. Zeng, and R.I. Glazer Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells Cancer Res 61 20 2001 7647 7653
20. S. Tanno, S. Tanno, and Y. Mitsuuchi AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells Cancer Res 61 2 2001 589 593
21. N. Humbert, N. Navaratnam, and A. Augert Regulation of ploidy and senescence by the AMPK-related kinase NUAK1 Embo J 29 2 2010 376 386
22. J. Li, H.Y. Guan, and L.Y. Gong Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival Clin Cancer Res 14 21 2008 6996 7003
23. R. Sun, P. Gao, and L. Chen Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells Cancer Res 65 4 2005 1433 1441
24. B. Zhang, Y. Ma, and H. Guo Akt2 is required for macrophage chemotaxis Eur J Immunol 39 3 2009 894 901
25. T. Takino, M. Nakada, and H. Miyamori CrkI adapter protein modulates cell migration and invasion in glioblastoma Cancer Res 63 9 2003 2335 2337
26. L. Liu, J. Wu, and Z. Ying Astrocyte elevated gene-1 upregulates matrix metalloproteinase-9 and induces human glioma invasion Cancer Res 70 9 2010 3750 3759
27. M. Sanson, Y. Marie, and S. Paris Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas J Clin Oncol 27 25 2009 4150 4154
28. S. Etienne-Manneville, and A. Hall Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta Cell 106 4 2001 489 498
29. S.H. Zigmond, M. Joyce, J. Borleis, G.M. Bokoch, and P.N. Devreotes Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42 J Cell Biol 138 2 1997 363 374
30. S. Arber, F.A. Barbayannis, and H. Hanser Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase Nature 393 6687 1998 805 809
31. M. Ghosh, X. Song, G. Mouneimne, M. Sidani, D.S. Lawrence, and J.S. Condeelis Cofilin promotes actin polymerization and defines the direction of cell motility Science 304 5671 2004 743 746
32. M. Nishita, C. Tomizawa, M. Yamamoto, Y. Horita, K. Ohashi, and K. Mizuno Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration J Cell Biol 171 2 2005 349 359
33. H. Sato, T. Takino, and Y. Okada A matrix metalloproteinase expressed on the surface of invasive tumour cells Nature 370 6484 1994 61 65
34. A. Suzuki, J. Lu, and G. Kusakai ARK5 is a tumor invasion-associated factor downstream of Akt signaling Mol Cell Biol 24 8 2004 3526 3535
35. P. Gulhati, K.A. Bowen, and J. Liu mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways Cancer Res 71 9 2011 3246 3256
36. S. Fruchon, S. Kheirallah, T. Al Saati, L Ysebaert, C Laurent, and L Leseux Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis Leukemia 26 4 2012 795 805
37. Y. Wang, Q. Sheng, M.A. Spillman, K. Behbakht, and H. Gu Gab2 regulates the migratory behaviors and E-cadherin expression via activation of the PI3K pathway in ovarian cancer cells Oncogene 31 20 2012 2512 2520
38. T.T. Tran, M. Uhl, and J.Y. Ma Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model Neuro Oncol 9 3 2007 259 270
39. G. Kusakai, A. Suzuki, and T. Ogura ARK5 expression in colorectal cancer and its implications for tumor progression Am J Pathol 164 3 2004 987 995
40. J. Noritake, T. Watanabe, K. Sato, S. Wang, and K. Kaibuchi IQGAP1: a key regulator of adhesion and migration J Cell Sci 118 Pt 10 2005 2085 2092
41. G. Mouneimne, V. DesMarais, and M. Sidani Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis Curr Biol 16 22 2006 2193 2205
42. S. Amos, M. Mut, and C.G. diPierro Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion Cancer Res 67 21 2007 10241 10251
43. J.S. Rao Molecular mechanisms of glioma invasiveness: the role of proteases Nat Rev Cancer 3 7 2003 489 501
44. S. Kondraganti, S. Mohanam, and S.K. Chintala Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion Cancer Res 60 24 2000 6851 6855
45. J.Y. An, K.M. Kim, and M.G. Choi Prognostic role of p-mTOR expression in cancer tissues and metastatic lymph nodes in pT2b gastric cancer Int J Cancer 126 12 2010 2904 2913
46. S. Han, J.D. Ritzenthaler, S.V. Sitaraman, and J. Roman Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells J Biol Chem 281 40 2006 29614 29624