Study on in vitro release and cell response to alendronate sodium-loaded ultrahigh molecular weight polyethylene loaded with alendronate sodium wear particles to treat the particles-induced osteolysis

Journal of Biomedical Materials Research - Part A

Volumn 101 A, Issue 2, 2013, Pages 394-403

  Qu, Shuxin ^a   Bai, Yinlong ^a   Liu, Xiaomin ^a   Fu, Rong ^b   Duan, Ke ^a   Weng, Jie ^a  

^a SOUTHWEST JIAOTONG UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Alendronate sodium; Cell response; In vitro drug release; UHMWPE; Wear debris

Indexed keywords

ALENDRONATE; ALENDRONATE SODIUMS (ALN); ALKALINE PHOSPHATASE ACTIVITY; ALN; BONE RESORPTION; BURST RELEASE; CELL RESPONSE; COCULTURE; CONTROL-CELL; IN-VITRO; INTERLEUKIN-6; MC3T3-E1; OSTEOBLAST PROLIFERATION; OSTEOLYSIS; RAPID RELEASE; SIZE RANGES; SLOW RELEASE; TUMOR NECROSIS FACTOR-ALPHA; WEAR DEBRIS; WEAR PARTICLES;

DEBRIS; MACROPHAGES; OSTEOBLASTS; PARTICLE SIZE; PHOSPHATASES; PLANTS (BOTANY); SODIUM;

ULTRAHIGH MOLECULAR WEIGHT POLYETHYLENES;

ALENDRONIC ACID; ALKALINE PHOSPHATASE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MACROPHAGE; MECHANICAL STRESS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; PARTICLE SIZE;

ALENDRONATE; ANIMALS; COCULTURE TECHNIQUES; MACROPHAGES; MICE; OSTEOBLASTS; OSTEOLYSIS; PARTICLE SIZE; POLYETHYLENES; PROSTHESIS FAILURE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84872675476     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34327     Document Type: Article

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