메뉴 건너뛰기




Volumn 85, Issue 3, 2013, Pages 345-355

Male contraceptive Adjudin is a potential anti-cancer drug

Author keywords

Adjudin; Anti cancer; Mitochondrial dysfunction

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADJUDIN; AF 2364; ANTINEOPLASTIC AGENT; CASPASE 3; CISPLATIN; LONIDAMINE; UNCLASSIFIED DRUG;

EID: 84872674745     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.11.008     Document Type: Article
Times cited : (25)

References (37)
  • 2
    • 67650744372 scopus 로고    scopus 로고
    • Immune therapy for cancer
    • M. Dougan, and G. Dranoff Immune therapy for cancer Annu Rev Immunol 27 2009 83 117
    • (2009) Annu Rev Immunol , vol.27 , pp. 83-117
    • Dougan, M.1    Dranoff, G.2
  • 3
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • R.W. Johnstone, A.A. Ruefli, and S.W. Lowe Apoptosis: a link between cancer genetics and chemotherapy Cell 108 2002 153 164
    • (2002) Cell , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 5
    • 77954739712 scopus 로고    scopus 로고
    • Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
    • Y. Geng, L. Kohli, B.J. Klocke, and K.A. Roth Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent Neuro-oncol 12 2010 473 481
    • (2010) Neuro-oncol , vol.12 , pp. 473-481
    • Geng, Y.1    Kohli, L.2    Klocke, B.J.3    Roth, K.A.4
  • 6
    • 66649116856 scopus 로고    scopus 로고
    • Chloroquine in glioblastoma - New horizons for an old drug
    • A. Munshi Chloroquine in glioblastoma - new horizons for an old drug Cancer 115 2009 2380 2383
    • (2009) Cancer , vol.115 , pp. 2380-2383
    • Munshi, A.1
  • 7
    • 23844478817 scopus 로고    scopus 로고
    • AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: A review of recent data
    • C.Y. Cheng, D. Mruk, B. Silvestrini, M. Bonanomi, C.H. Wong, and M.K. Siu AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data Contraception 72 2005 251 261
    • (2005) Contraception , vol.72 , pp. 251-261
    • Cheng, C.Y.1    Mruk, D.2    Silvestrini, B.3    Bonanomi, M.4    Wong, C.H.5    Siu, M.K.6
  • 8
    • 0034915521 scopus 로고    scopus 로고
    • Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis
    • C.Y. Cheng, B. Silvestrini, J. Grima, M.Y. Mo, L.J. Zhu, and E. Johansson Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis Biol Reprod 65 2001 449 461
    • (2001) Biol Reprod , vol.65 , pp. 449-461
    • Cheng, C.Y.1    Silvestrini, B.2    Grima, J.3    Mo, M.Y.4    Zhu, L.J.5    Johansson, E.6
  • 9
    • 33750735046 scopus 로고    scopus 로고
    • A male contraceptive targeting germ cell adhesion
    • D.D. Mruk, C.H. Wong, B. Silvestrini, and C.Y. Cheng A male contraceptive targeting germ cell adhesion Nat Med 12 2006 1323 1328
    • (2006) Nat Med , vol.12 , pp. 1323-1328
    • Mruk, D.D.1    Wong, C.H.2    Silvestrini, B.3    Cheng, C.Y.4
  • 10
    • 59649084165 scopus 로고    scopus 로고
    • TGF-beta3 and TNFalpha perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: A new concept of BTB regulation during spermatogenesis
    • W. Xia, E.W. Wong, D.D. Mruk, and C.Y. Cheng TGF-beta3 and TNFalpha perturb blood-testis barrier (BTB) dynamics by accelerating the clathrin-mediated endocytosis of integral membrane proteins: a new concept of BTB regulation during spermatogenesis Dev Biol 327 2009 48 61
    • (2009) Dev Biol , vol.327 , pp. 48-61
    • Xia, W.1    Wong, E.W.2    Mruk, D.D.3    Cheng, C.Y.4
  • 11
    • 34247225991 scopus 로고    scopus 로고
    • C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes
    • W. Xia, D.D. Mruk, and C.Y. Cheng C-type natriuretic peptide regulates blood-testis barrier dynamics in adult rat testes Proc Natl Acad Sci USA 104 2007 3841 3846
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3841-3846
    • Xia, W.1    Mruk, D.D.2    Cheng, C.Y.3
  • 14
    • 0033594404 scopus 로고    scopus 로고
    • Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
    • L. Ravagnan, I. Marzo, P. Costantini, S.A. Susin, N. Zamzami, and P.X. Petit Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore Oncogene 18 1999 2537 2546
    • (1999) Oncogene , vol.18 , pp. 2537-2546
    • Ravagnan, L.1    Marzo, I.2    Costantini, P.3    Susin, S.A.4    Zamzami, N.5    Petit, P.X.6
  • 15
    • 0035877967 scopus 로고    scopus 로고
    • Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis
    • O. Sordet, C. Rebe, I. Leroy, J.M. Bruey, C. Garrido, and C. Miguet Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis Blood 97 2001 3931 3940
    • (2001) Blood , vol.97 , pp. 3931-3940
    • Sordet, O.1    Rebe, C.2    Leroy, I.3    Bruey, J.M.4    Garrido, C.5    Miguet, C.6
  • 16
    • 0038206442 scopus 로고    scopus 로고
    • Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme
    • S. Oudard, A. Carpentier, E. Banu, F. Fauchon, D. Celerier, and M.F. Poupon Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme J Neurooncol 63 2003 81 86
    • (2003) J Neurooncol , vol.63 , pp. 81-86
    • Oudard, S.1    Carpentier, A.2    Banu, E.3    Fauchon, F.4    Celerier, D.5    Poupon, M.F.6
  • 17
    • 34547866709 scopus 로고    scopus 로고
    • Endothelial progenitor cells as a new agent contributing to vascular repair
    • E. Miller-Kasprzak, and P.P. Jagodzinski Endothelial progenitor cells as a new agent contributing to vascular repair Arch Immunol Ther Exp (Warsz) 55 2007 247 259
    • (2007) Arch Immunol Ther Exp (Warsz) , vol.55 , pp. 247-259
    • Miller-Kasprzak, E.1    Jagodzinski, P.P.2
  • 18
    • 80053580456 scopus 로고    scopus 로고
    • The packaging of siRNA within the mesoporous structure of silica nanoparticles
    • X. Li, Q.R. Xie, J. Zhang, W. Xia, and H. Gu The packaging of siRNA within the mesoporous structure of silica nanoparticles Biomaterials 32 2011 9546 9556
    • (2011) Biomaterials , vol.32 , pp. 9546-9556
    • Li, X.1    Xie, Q.R.2    Zhang, J.3    Xia, W.4    Gu, H.5
  • 19
    • 67649399288 scopus 로고    scopus 로고
    • Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
    • R.K. Dagda, S.J. Cherra 3rd, S.M. Kulich, A. Tandon, D. Park, and C.T. Chu Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission J Biol Chem 284 2009 13843 13855
    • (2009) J Biol Chem , vol.284 , pp. 13843-13855
    • Dagda, R.K.1    Cherra III, S.J.2    Kulich, S.M.3    Tandon, A.4    Park, D.5    Chu, C.T.6
  • 20
    • 77957264938 scopus 로고    scopus 로고
    • Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo
    • L. Su, C.Y. Cheng, and D.D. Mruk Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo Int J Biochem Cell Biol 42 2010 1864 1875
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1864-1875
    • Su, L.1    Cheng, C.Y.2    Mruk, D.D.3
  • 22
    • 0033791574 scopus 로고    scopus 로고
    • Control of apoptotic DNA degradation
    • K.F. Ferri, and G. Kroemer Control of apoptotic DNA degradation Nat Cell Biol 2 2000 E63 E64
    • (2000) Nat Cell Biol , vol.2
    • Ferri, K.F.1    Kroemer, G.2
  • 23
    • 34548207775 scopus 로고    scopus 로고
    • Mechanism of cell death caused by complex i defects in a rat dopaminergic cell line
    • M. Marella, B.B. Seo, A. Matsuno-Yagi, and T. Yagi Mechanism of cell death caused by complex I defects in a rat dopaminergic cell line J Biol Chem 282 2007 24146 24156
    • (2007) J Biol Chem , vol.282 , pp. 24146-24156
    • Marella, M.1    Seo, B.B.2    Matsuno-Yagi, A.3    Yagi, T.4
  • 24
    • 80255123508 scopus 로고    scopus 로고
    • Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation
    • E. Calvino, M.C. Estan, G.P. Simon, P. Sancho, C. Boyano-Adanez Mdel, and E. de Blas Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation Biochem Pharmacol 82 2011 1619 1629
    • (2011) Biochem Pharmacol , vol.82 , pp. 1619-1629
    • Calvino, E.1    Estan, M.C.2    Simon, G.P.3    Sancho, P.4    Boyano-Adanez Mdel, C.5    De Blas, E.6
  • 25
    • 0037174915 scopus 로고    scopus 로고
    • Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells
    • Y.C. Li, K.P. Fung, T.T. Kwok, C.Y. Lee, Y.K. Suen, and S.K. Kong Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells Life Sci 71 2002 2729 2740
    • (2002) Life Sci , vol.71 , pp. 2729-2740
    • Li, Y.C.1    Fung, K.P.2    Kwok, T.T.3    Lee, C.Y.4    Suen, Y.K.5    Kong, S.K.6
  • 26
    • 0035891212 scopus 로고    scopus 로고
    • Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437
    • A.S. Belzacq, C. El Hamel, H.L. Vieira, I. Cohen, D. Haouzi, and D. Metivier Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437 Oncogene 20 2001 7579 7587
    • (2001) Oncogene , vol.20 , pp. 7579-7587
    • Belzacq, A.S.1    El Hamel, C.2    Vieira, H.L.3    Cohen, I.4    Haouzi, D.5    Metivier, D.6
  • 27
    • 33745274726 scopus 로고    scopus 로고
    • Mitochondria: Dynamic organelles in disease, aging, and development
    • D.C. Chan Mitochondria: dynamic organelles in disease, aging, and development Cell 125 2006 1241 1252
    • (2006) Cell , vol.125 , pp. 1241-1252
    • Chan, D.C.1
  • 28
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 29
    • 0024325795 scopus 로고
    • The combined use of radiation therapy and lonidamine in the treatment of brain metastases
    • L.M. DeAngelis, V.E. Currie, J.H. Kim, G. Krol, M.A. O'Hehir, and F.M. Farag The combined use of radiation therapy and lonidamine in the treatment of brain metastases J Neurooncol 7 1989 241 247
    • (1989) J Neurooncol , vol.7 , pp. 241-247
    • Deangelis, L.M.1    Currie, V.E.2    Kim, J.H.3    Krol, G.4    O'Hehir, M.A.5    Farag, F.M.6
  • 30
    • 0020682326 scopus 로고
    • Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems
    • B. Silvestrini, G.M. Hahn, V. Cioli, and C. De Martino Effects of lonidamine alone or combined with hyperthermia in some experimental cell and tumour systems Br J Cancer 47 1983 221 231
    • (1983) Br J Cancer , vol.47 , pp. 221-231
    • Silvestrini, B.1    Hahn, G.M.2    Cioli, V.3    De Martino, C.4
  • 32
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • B.I. Rini, S. Halabi, J.E. Rosenberg, W.M. Stadler, D.A. Vaena, and L. Archer Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206 J Clin Oncol 28 2010 2137 2143
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Archer, L.6
  • 33
    • 0142058027 scopus 로고    scopus 로고
    • Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide
    • P. Papaldo, M. Lopez, E. Cortesi, E. Cammilluzzi, M. Antimi, and E. Terzoli Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide J Clin Oncol 21 2003 3462 3468
    • (2003) J Clin Oncol , vol.21 , pp. 3462-3468
    • Papaldo, P.1    Lopez, M.2    Cortesi, E.3    Cammilluzzi, E.4    Antimi, M.5    Terzoli, E.6
  • 34
    • 79955824328 scopus 로고    scopus 로고
    • A potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes
    • K.W. Mok, D.D. Mruk, P.P. Lie, W.Y. Lui, and Cheng C.Y. Adjudin a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes Reproduction 141 2011 571 580
    • (2011) Reproduction , vol.141 , pp. 571-580
    • Mok, K.W.1    Mruk, D.D.2    Lie, P.P.3    Lui, W.Y.4    Adjudin, C.C.Y.5
  • 35
    • 83755178073 scopus 로고    scopus 로고
    • A study to assess the assembly of a functional blood-testis barrier in developing rat testes
    • K.W. Mok, D.D. Mruk, W.M. Lee, and C.Y. Cheng A study to assess the assembly of a functional blood-testis barrier in developing rat testes Spermatogenesis 1 2011 270 280
    • (2011) Spermatogenesis , vol.1 , pp. 270-280
    • Mok, K.W.1    Mruk, D.D.2    Lee, W.M.3    Cheng, C.Y.4
  • 36
    • 33645657886 scopus 로고    scopus 로고
    • The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis
    • E. Naumova, P. Ubezio, A. Garofalo, P. Borsotti, L. Cassis, and E. Riccardi The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis Clin Cancer Res 12 2006 1839 1849
    • (2006) Clin Cancer Res , vol.12 , pp. 1839-1849
    • Naumova, E.1    Ubezio, P.2    Garofalo, A.3    Borsotti, P.4    Cassis, L.5    Riccardi, E.6
  • 37
    • 84862504617 scopus 로고    scopus 로고
    • Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells
    • Q. Liu, J. Zhang, W. Sun, Q.R. Xie, W. Xia, and H. Gu Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells Int J Nanomed 7 2012 999 1013
    • (2012) Int J Nanomed , vol.7 , pp. 999-1013
    • Liu, Q.1    Zhang, J.2    Sun, W.3    Xie, Q.R.4    Xia, W.5    Gu, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.