Analysis of p53 and miRNA expression after irradiation of glioblastoma cell lines

Anticancer Research

Volumn 32, Issue 11, 2012, Pages 4709-4714

  Sasaki, Akiko ^a   Udaka, Yuko ^a   Tsunoda, Yuko ^b   Yamamoto, Gou ^a   Tsuji, Mayumi ^a   Oyamada, Hideto ^a   Oguchi, Katsuji ^a   Mizutani, Tohru ^a  

^a SHOWA UNIVERSITY   (Japan)

^b KAMEDA MEDICAL CENTER   (Japan)

Author keywords

A172 cells; Glioblastoma; miRNA; p53

Indexed keywords

CASPASE 9; MICRORNA; MICRORNA 222; MICRORNA 34A; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IRRADIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY;

APOPTOSIS; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; MICRORNAS; RADIATION TOLERANCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84872669191     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H, Budach V and Jordan A: Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol 103: 317-324, 2011.
2. Li Y, Zhao S, Zhen Y, Li Q, Teng L, Asai A and Kawamoto K: A miR-21 inhibitor enhances apoptosis and reduces G(2)-M accumulation induced by ionizing radiation in human glioblastoma U251 cells. Brain Tumor Pathol 28: 209-214, 2011.
3. Zhang JS, Nakatsugawa S, Niwa O, Ju GZ and Liu SZ:Ionizing radiation-induced IL-1 alpha, IL-6 and GM-CSF production by human lung cancer cells. Chin Med J 107: 653-657, 1994.
4. Svendsen A, Verhoeff JJ, Immeryoll H, Brogger JC, Kmiecik J, Poli A, Netland IA, Prestegarden L, Planaguma J, Torsvik A, Kjersem AB, Sakariassen PO, Heggdal JI, Van Furth WR, Bjerkvig R, Lund-Johansen M, Enger PO, Frlsberh J, Brons NH, Tronstad KJ, Waha A and Chekenya M: Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathol 122: 495-510, 2011.
5. Carrington JC and Ambros V: Role of microRNAs in plant and animal development. Science 301: 336-338, 2003.
6. Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R and Rajewsky N: Widespread changes in protein synthesis induced by microRNAs. Nature 455: 58-63, 2008.
7. Weeraratne SD, Amani V, Neiss A, Teider N, Scott DK, Pomery SL and Cho YJ: miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma. Neuro Oncol 13: 165-175, 2011.
8. Niemoeller OM, Niyazi M, Corradini S: MicroRNA expression profiles in human cancer cells after ionizing radiation. Radiat Oncol 31: 29, 2011.
9. Silber J, Jacobsen A, Ozawa T, Harinath G, Pedraza A, Sander C, Holland EC and Huse JT: miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis. PLoS One 7: e33844, 2012.
10. Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, Johnson E, Marcinkiewicz L, Jiang J, Yang Y, Schmittgen TD, Lopes B, Schiff D, Purow B and Abounader R: MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 69: 7569-7576, 2009.
11. Zhou X, Zhang J, Ren Y, Wang Y, Shi L, Liu N, Wang G, Pi P, You Y and Kang C: Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncol Rep 24: 195-201, 2010.
12. Papagiannakopoulos T, Shapiro A and Kosik KS: MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 68: 8164-8172, 2008.
13. Chen L, Zhang J, Han L, Zhang A, Zhang C, Zheng Y, Jiang Y, Jiang T, Pu P, Jiang C and Kang C: Down-regulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. Oncol Rep 27: 854-860, 2012.
14. Villalonga-Planells R, Coll-Mulet L, Martínez-Soler F, Castaño E, Acebes JJ, Giménez-Bonafé P, Gil J and Tortosa A: Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme. PLoS One 6: e 18588, 2011.
15. Haas-Kogan DA, Dazin P, Hu L, Deen DF and Israsl A: P53-independent apoptosis: a mechanism of radiation-induced cell death of glioblastoma cells. Cancer J Sci Am 2: 114-121, 1996.
16. Suh SS, Yoo JY, Nuovo GH, Jeon YJ, Kim S, Lee TJ, Kim T, Bakacs A, Alder H, Kaur B, Aqeilan RI, Pichiorri F and Croce CM: MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme.Proc Natl Acad Sci USA 109: 5316-21, 2012.