The expression and significance of WWOX and β-catenin in hepatocellular carcinoma

APMIS

Volumn 121, Issue 2, 2013, Pages 120-126

  Li, Yu Pu ^a   Wu, Chun Chieh ^b   Chen, Wan Tzu ^b   Huang, Ya Chun ^c   Chai, Chee Yin ^a,b,c  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

catenin; Hepatocellular carcinoma; Immunohistochemical staining; Tumor suppressor gene; WWOX

Indexed keywords

BETA CATENIN; OXIDOREDUCTASE; UNCLASSIFIED DRUG; WW DOMAIN CONTAINING OXIDOREDUCTASE ENZYME;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CLINICAL FEATURE; DISEASE SEVERITY; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY;

ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; DOWN-REGULATION; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; OXIDOREDUCTASES; RETROSPECTIVE STUDIES; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; TUMOR SUPPRESSOR PROTEINS; WNT SIGNALING PATHWAY;

EID: 84872664583     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2012.02947.x     Document Type: Article

References (25)

1. Parkin DM, Bray F, Ferlay J, Pisani P Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001;94:153-6.
2. Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, et al. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res 2001;61:8068-73.
3. Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, et al. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci USA 2005;102:15611-6.
4. Aqeilan RI, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, et al. Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci USA 2007;104:3949-54.
5. Bouteille N, Driouch K, Hage PE, Sin S, Formstecher E, Camonis J, et al. Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene 2009;28:2569-80.
6. Nunez MI, Ludes-Meyers J, Aldaz CM WWOX protein expression in normal human tissues. J Mol Histol 2006;37:115-25.
7. Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer 2004;91:753-9.
8. Bosman FT, Carneiro F, Hruban RH, Theise ND WHO Classification of Tumours of the Digestive System. 4th edn, Lyon, France: IARC, 2010.
9. Edge SB, Byrd DR AJCC Cancer Staging Manual. 7th edn, New York, NY, USA: Springer, 2009.
10. Donati V, Fontanini G, Dell'Omodarme M, Prati MC, Nuti S, Lucchi M, et al. WWOX expression in different histologic types and subtypes of non-small cell lung cancer. Clin Cancer Res 2007;13:884-91.
11. Lopez-Knowles E, Zardawi SJ, McNeil CM, Millar EK, Crea P, Musgrove EA, et al. Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients. Cancer Epidemiol Biomarkers Prev 2010;19:301-9.
12. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res 2000;60:2140-5.
13. Qin HR, Iliopoulos D, Semba S, Fabbri M, Druck T, Volinia S, et al. A role for the WWOX gene in prostate cancer. Cancer Res 2006;66:6477-81.
14. Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, et al. Loss of WWOX expression in gastric carcinoma. Clin Cancer Res 2004;10:3053-8.
15. Guler G, Uner A, Guler N, Han SY, Iliopoulos D, McCue P, et al. Concordant loss of fragile gene expression early in breast cancer development. Pathol Int 2005;55:471-8.
16. Nunez MI, Ludes-Meyers J, Abba MC, Kil H, Abbey NW, Page RE, et al. Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status. Breast Cancer Res Treat 2005;89:99-105.
17. Pimenta FJ, Gomes DA, Perdigao PF, Barbosa AA, Romano-Silva MA, Gomez MV, et al. Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas. Int J Cancer 2006;118:1154-8.
18. Nunez MI, Rosen DG, Ludes-Meyers JH, Abba MC, Kil H, Page R, et al. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer 2005;5:64.
19. Pluciennik E, Kusinska R, Potemski P, Kubiak R, Kordek R, Bednarek AK WWOX - the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis. Eur J Surg Oncol 2006;32:153-7.
20. Wang X, Chao L, Ma G, Chen L, Zang Y, Sun J The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype. J Cancer Res Clin Oncol 2011;137:271-8.
21. Ramos D, Abba M, Lopez-Guerrero JA, Rubio J, Solsona E, Almenar S, et al. Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours. Histopathology 2008;52:831-9.
22. Polakis P Wnt signaling and cancer. Genes Dev 2000;14:1837-51.
23. Whittaker S, Marais R, Zhu AX The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010;29:4989-5005.
24. Wong CM, Fan ST, Ng IO Beta-catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer 2001;92:136-45.
25. Zhao DH, Hong JJ, Guo SY, Yang RL, Yuan J, Wen CY, et al. Aberrant expression and function of TCF4 in the proliferation of hepatocellular carcinoma cell line BEL-7402. Cell Res 2004;14:74-80.