The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 2, 2011, Pages 271-278

  Wang, Xiao ^a   Chao, Lan ^b   Ma, Guohui ^a   Chen, Liansheng ^a   Zang, Yixiu ^a   Sun, Jingzhong ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Basal like phenotype; Breast cancer; CK5 6; EGFR; Gene; WWOX

Indexed keywords

CYTOKERATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ONCOPROTEIN; OSTEOPONTIN; UNCLASSIFIED DRUG; WW DOMAIN CONTAINING OXIDOREDUCTASE;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CONTROLLED STUDY; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL TIME;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, BASAL CELL; CONFOUNDING FACTORS (EPIDEMIOLOGY); DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; NEOPLASM STAGING; ODDS RATIO; OXIDOREDUCTASES; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SAMPLE SIZE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 78751631889     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-010-0880-1     Document Type: Article

References (32)

1. RI Aqeilan T Kuroki O Pekarsky, et al. 2004 Loss of WWOX expression in gastric carcinoma Clin Can Res 10 9 3053 3058 1:CAS:528:DC%2BD2cXjs12lsbk%3D 10.1158/1078-0432.CCR-03-0594 (Pubitemid 38619682)
2. AK Bednarek KJ Laflin RL Daniel Q Liao KA Hawkins CM Aldaz 2000 WWOX, a novel domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer Cancer Res 60 8 2140 2145 1:CAS:528:DC%2BD3cXivVaksLk%3D 10786676
3. AK Bednarek CL Keck-Waggoner RL Daniel, et al. 2001 WWOX, the FRA16D gene, behaves as a suppressor of tumor growth Cancer Res 61 22 8068 8073 1:CAS:528:DC%2BD3MXovVShsrw%3D 11719429
4. MC Cheang D Voduc C Bajdik, et al. 2008 Basal-like breast cancer defined by 5 biomarkers has superior prognostic value than triple-negative phenotype Clin Cancer Res 14 5 1368 1376 1:CAS:528:DC%2BD1cXislSrs7o%3D 10.1158/1078-0432.CCR-07-1658 18316557 (Pubitemid 351413917)
5. Greene FI, Page DI, Fleming ID (2002) AJCC cancer staging manual, 6th edn. Springer, New York
6. G Guler A Ulner N Guler, et al. 2004 The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma Cancer 100 8 1605 1614 1:CAS:528:DC%2BD2cXjvFygt7c%3D 10.1002/cncr.20137 15073846 (Pubitemid 38456335)
7. G Guler D Iliopoulos N Guler C Himmetoglu M Hayran K Huebner 2007 WWOX and Ap2r expression levels predict tamoxifen response Clin Cancer Res 13 6115 6121 1:CAS:528:DC%2BD2sXhtFygs7fI 10.1158/1078-0432.CCR-07-1282 17947476 (Pubitemid 350075070)
8. BG Haffty Q Yang M Reiss, et al. 2006 Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer J Clin Oncol 24 36 5652 5657 10.1200/JCO.2006.06.5664 17116942 (Pubitemid 46631305)
9. D Iliopoulos G Guler SH-Y Han, et al. 2005 Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer Oncogene 24 9 1625 1633 1:CAS:528:DC%2BD2MXhsFOqsbg%3D 10.1038/sj.onc.1208398 15674328 (Pubitemid 40396092)
10. D Iliopoulos M Fabbri T Druck HR Qin SY Han K Huebner 2007 Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of WWOX expression Clin Cancer Res 13 1 268 274 1:CAS:528:DC%2BD2sXotlWm 10.1158/1078-0432.CCR-06-2038 17200365 (Pubitemid 46121879)
11. RE Jimenez T Wallis DW Visscher 2001 Centrally necrotizing carcinomas of the breast: a distinct histologic subtype with aggressive clinical behavior Am J Surg Pathol 25 3 331 337 1:STN:280:DC%2BD3M7lvFeqsw%3D%3D 10.1097/00000478- 200103000-00007 11224603 (Pubitemid 32174202)
12. B Kreike M van Kouwenhove H Horlings, et al. 2007 Gene expression profiling and histopathological characterization of triple negative/basal-like breast carcinomas Breast Cancer Res 9 5 R65 10.1186/bcr1771 17910759 (Pubitemid 350187481)
13. T Kuroki F Trapasso T Shiraishi, et al. 2002 Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma Cancer Res 62 8 2258 2260 1:CAS:528:DC%2BD38Xjt1ejtLY%3D 11956080
14. T Kuroki S Yendamuri F Trapasso, et al. 2004 The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis Clin Cancer Res 10 7 2459 2465 1:CAS:528:DC%2BD2cXivFSqsLk%3D 10.1158/1078-0432.CCR-03-0096 15073125 (Pubitemid 38445707)
15. V Le Doussal M Tubiana-Hulin S Friedman K Hacene F Spyratos M Brunet 1989 Prognostic value of histologic grade nuclear components of Scarff-Bloom- Richardson (SBR): an improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas Cancer 64 9 1914 1921 1:STN:280:DyaK3c%2Fgt1Oqtg%3D%3D 10.1002/1097-0142(19891101)64:9<1914::AID- CNCR2820640926>3.0.CO;2-G 2551477
16. CA Livasy G Karaca R Nanda, et al. 2006 Phenotype evaluation of the basal-like subtype of invasive breast carcinoma Mod Pathol 19 2 264 271 1:CAS:528:DC%2BD28Xlt1eqtw%3D%3D 10.1038/modpathol.3800528 16341146 (Pubitemid 43117611)
17. TO Nielsen FD Hsu K Jensen, et al. 2004 Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma Clin Cancer Res 10 16 5367 5374 1:CAS:528:DC%2BD2cXmvFSlt7k%3D 10.1158/1078-0432.CCR- 04-0220 15328174 (Pubitemid 39100473)
18. MI Nunez DG Rosen JH Ludes-Meyers, et al. 2005 WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome BMC Cancer 5 1 64 10.1186/1471-2407-5-64 15982416 (Pubitemid 41461067)
19. MI Nunez J Ludes-Meyers MC Abba, et al. 2005 Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status Breast Cancer Res Treat 89 2 99 105 10.1007/s10549-004-1474-x 15692750 (Pubitemid 40249042)
20. AJ Paige KJ Taylor C Taylor, et al. 2001 WWOX: a candidate tumor suppressor gene involved in multiple tumor types Proc Natl Acad Sci 98 20 11417 11422 1:CAS:528:DC%2BD3MXnt1yquro%3D 10.1073/pnas.191175898 11572989 (Pubitemid 32928743)
21. RR Parikh D Housman Y Qifeng D Toppmeyer LD Wilson BG Haffty 2008 Prognostic value of triple-negative phenotype at the time of locally recurrent, conservatively treated breast cancer Int J Radiat Oncol Biol Phys 72 4 1 8
22. RR Parikh Q Yang SA Higgins BG Haffty 2008 Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression Int J Radiat Oncol Biol Phys 70 1 35 42 10.1016/j.ijrobp.2007.05.066 17855007 (Pubitemid 350251027)
23. SW Park J Ludes-Meyers DB Zimonjic ME Durkin NC Popescu CM Aldaz 2004 Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma Br J Cancer 91 4 753 759 1:CAS:528:DC%2BD2cXmsVCgsbs%3D 15266310
24. CM Perou T Sorlie MB Eisen, et al. 2000 Molecular portraits of human breast tumours Nature 406 6797 747 752 1:CAS:528:DC%2BD3cXmt1CnsLw%3D 10.1038/35021093 10963602
25. A Purohit SP Newman MJ Reed 2002 The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer Breast Cancer Res 4 2 65 69 1:CAS:528:DC%2BD38XitlOltbo%3D 10.1186/bcr425 11879566 (Pubitemid 34248122)
26. EA Rakha ME El-Sayed AR Green AH Lee JF Robertson IO Ellis 2007 Prognostic markers in triple-negative breast cancer Cancer 109 1 25 32 1:CAS:528:DC%2BD2sXhtVKrtLY%3D 10.1002/cncr.22381 17146782 (Pubitemid 46120191)
27. EA Rakha JS Reis-Filho IO Ellis 2008 Basal-like breast cancer: a critical review J Clin Oncol 26 15 2568 2581 10.1200/JCO.2007.13.1748 18487574
28. T Sorlie R Tibshirani J Parker, et al. 2003 Repeated observation of breast tumor subtypes in independent gene expression data sets Proc Natl Acad Sci USA 100 14 8418 8423 1:CAS:528:DC%2BD3sXlsFGntLk%3D 10.1073/pnas.0932692100 12829800 (Pubitemid 36842560)
29. AB Tuck FP O'Malley H Singhal, et al. 1997 Osteopontin and p53 expression are associated with tumor progression in a case of synchronous, bilateral, invasive mammary carcinomas Arch Pathol Lab Med 121 6 578 584 1:STN:280:DyaK2szkt12ktw%3D%3D 9199622
30. BC Turner AA Gumbs D Carter PM Glazer BG Haffty 2004 Cyclin D1 expression and early breast cancer recurrence following lumpectomy and radiation Int J Radiat Oncol Biol Phys 47 5 1169 1176
31. X Wang L Chao G Ma, et al. 2008 Increased expression of osteopontin in patients with triple-negative breast cancer Eur J Clin Invest 38 6 438 446 1:CAS:528:DC%2BD1cXnvVOks7g%3D 10.1111/j.1365-2362.2008.01956.x 18452545 (Pubitemid 351712928)
32. S Yendamuri T Kuroki F Trapasso, et al. 2003 WW Domain containing oxidoreductase gene expression is altered in non-small cell lung cancer Cancer Res 63 4 878 881 1:CAS:528:DC%2BD3sXht1GqsLY%3D 12591741