Hepatic cytokine response can be modulated using the Kupffer cell blocker gadolinium chloride in obstructive jaundice

International Journal of Surgery

Volumn 11, Issue 1, 2013, Pages 46-51

  Jones, C ^a   Badger, S A ^a   Hoper, M ^a   Parks, R W ^a   Diamond, T ^a   Taylor, M A ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Cytokine response; Gadolinium chloride; Kupffer cells

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYTOKINE; GADOLINIUM CHLORIDE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT LIGATION; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENDOTOXEMIA; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LIVER; LIVER PERFUSION; MALE; MORTALITY; NONHUMAN; OBSTRUCTIVE JAUNDICE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BILIRUBIN; BODY WEIGHT; CELL COUNT; ENDOTOXEMIA; GADOLINIUM; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; JAUNDICE, OBSTRUCTIVE; KUPFFER CELLS; LIVER; MALE; MICE; PERFUSION; RANDOM ALLOCATION; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84872620970     PISSN: 17439191     EISSN: 17439159     Source Type: Journal    
DOI: 10.1016/j.ijsu.2012.11.008     Document Type: Article

References (29)

1. Yorgani K., Baykal A., Kologlu M., Saribas Z., Hascelik G., Sayek I. Endotoxin challenge causes a proinflammatory state in obstructive jaundice. J Invest Surg 2004, 17:119-126.
2. Parks R.W., Halliday M.I., McCrory D.C., Erwin P., Smye M., Diamond T., et al. Host immune responses and intestinal permeability in patients with jaundice. Br J Surg 2003, 90:239-245.
3. O'Neill P.J., Ayala A., Wang P., Ba Z.F., Morrison M.H., Schultze A.E., et al. Role of Kupffer cells in interleukin-6 release following trauma-haemorrhage and resuscitation. Shock 1994, 1:43-47.
4. Iimuro Y., Yamamoto M., Kohno H., Itakura J., Fujii H., Matsumoto Y. Blockade of liver macrophages by gadolinium chloride reduces lethality in endotoxemic rats - analysis of mechanisms of lethality in endotoxemia. J Leukoc Biol 1994, 55:723-728.
5. Vollmar B., Ruttinger D., Wanner G.A., Leiderer R., Menger M.D. Modulation of kupffer cell activity by gadolinium chloride in endotoxemic rats. Shock 1996, 6:434-441.
6. Suzuki S., Toledo-Pereyra L.H., Rodriguez F., Lopez F. Role of Kupffer cells in neutrophil activation and infiltration following total hepatic ischemia and reperfusion. Circ Shock 1994, 42:204-209.
7. Schemmer P., Enomoto N., Bradford B.U., Bunzendahl H., Raleigh J.A., Lemasters J.J., et al. Activated Kupffer cells cause a hypermetabolic state after gentle in situ manipulation of liver in rats. Am J Physiol Gastrointest Liver Physiol 2001, 280:G1076-G1082.
8. Koo D.J., Chaudry I.H., Wang P. Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. J Surg Res 1999, 83:151-157.
9. Callery M.P., Kamei T., Flye M.W. Kupffer cell blockade increases mortality during intra-abdominal sepsis despite improving systemic immunity. Arch Surg 1990, 125:36-41.
10. Roggin K.K., Papa E.F., Kurkchubasche A.G., Tracy T.F. Kupffer cell inactivation delays repair in a rat model of reversible biliary obstruction. J Surg Res 2000, 90:166-173.
11. Kennedy J.A., Lewis H., Clements W.D., Kirk S.J., Campbell G., Halliday M.I., et al. Kupffer cell blockade, tumour necrosis factor secretion and survival following endotoxin challenge in experimental biliary obstruction. Br J Surg 1999, 86:1410-1414.
12. Spencer A.J., Wilson S.A., Batchelor J., Reid A., Rees J., Harpur E. Gadolinium chloride toxicity in the rat. Toxicol Pathol 1997, 25:245-255.
13. Hardonk M.J., Dijkhuis F.W., Hulstaert C.E., Koudstaal J. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukoc Biol 1992, 52:296-302.
14. Clements W.D., Diamond T., McCrory D.C., Rowlands B.J. Biliary drainage in obstructive jaundice: experimental and clinical aspects. Br J Surg 1993, 80:834-842.
15. Dijkstra C.D., Dopp E.A., Joling P., Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985, 54:589-599.
16. Lewis A., Harkin D.H., Taylor M.A., Hoper M., Barros D'Sa A.A.B. Lower limb ischaemia-reperfusion induced remote hepatic injury is not altered by Kupffer cell depletion. Proceedings of the 37th Congress of the European Society for Surgical Research 2002, Monduzzi Editore, Hungary.
17. Ayala A., O'Neill P.J., Uebele S.A., Herdon C.D., Chaudry I.H. Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators. J Trauma 1997, 42:882-888.
18. Husztik E., Lazar G., Parducz A. Electron microscopic study of Kupffer-cell phagocytosis blockade induced by gadolinium chloride. Br J Exp Pathol 1980, 61:624-630.
19. Kono H., Fujii H., Asakawa M., Yamamoto M., Maki A., Matsuda M., et al. Functional heterogeneity of the Kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin. J Surg Res 2002, 106:179-187.
20. Kennedy J.A. Characterization and modulation of Kupffer cell function in experimental obstructive jaundice 1997, Department of Surgery, Queen's University Belfast.
21. Ruttinger D., Vollmar B., Wanner G.A., Messmer K. In vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade. J Hepatol 1996, 25:960-967.
22. Gloor B., Blinman T.A., Rigberg D.A., Todd K.E., Lane J.S., Hines O.J., et al. Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats. Pancreas 2000, 21:414-420.
23. Iwai M., Cui T.X., Kitamura H., Saito M., Shimazu T. Increased secretion of tumour necrosis factor and interleukin 6 from isolated, perfused liver of rats after partial hepatectomy. Cytokine 2001, 13:60-64.
24. Parlesak A., Schaeckeler S., Moser L., Bode C. Conjugated primary bile salts reduce permeability of endotoxin through intestinal epithelial cells and synergize with phosphatidylcholine in suppression of inflammatory cytokine production. Crit Care Med 2007, 35:2367-2374.
25. Koutelidakis I., Papaziogas B., Giamarellos-Bourboulis E.J., Makris J., Pavlidis T., Giamarellou H., et al. Systemic endotoxaemia following obstructive jaundice: the role of lactulose. J Surg Res 2003, 113:243-247.
26. Abraham S., Szabo A., Paszt A., Duda E., Lazar G. Consequences of Kupffer cell blockade on endotoxin-induced inflammatory and hepatic microcirculatory reactions during biliary obstruction. Magy Seb 2009, 62:298-303.
27. Abraham S., Szabo A., Kaszaki J., Varga R., Eder K., Duda E., et al. Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice. Shock 2008, 30:69-74.
28. Badger D.A., Kuester R.K., Sauer J.M., Sipes I.G. Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity. Toxicology 1997, 121:143-153.
29. Ruttinger D., Vollmar B., Kempter B., Messmer K. Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival. Langenbecks Arch Surg 1998, 383:75-80.