Allergen component testing for food allergy: Ready for prime time?

Current Allergy and Asthma Reports

Volumn 13, Issue 1, 2013, Pages 58-63

  Kattan, Jacob D ^a   Wang, Julie ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Component resolved diagnostics; Diagnosis; Egg allergy; Food allergy; Food specific IgE; Hazelnut allergy; Microarray; Milk allergy; Oral food challenge; Peanut allergy; Sensitivity; Shrimp allergy; Skin prick testing; Specificity

Indexed keywords

CASEIN; FOOD ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; LACTOFERRIN; LACTOGLOBULIN; OVOTRANSFERRIN; SERUM ALBUMIN; TROPOMYOSIN;

ALLERGENICITY; ALLERGIC REACTION; ALLERGY TEST; ARTICLE; CLINICAL EVALUATION; COMPONENT RESOLVED DIAGNOSTICS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; EGG ALLERGY; ENZYME IMMUNOASSAY; FOOD ALLERGY; HAZELNUT ALLERGY; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGY TEST KIT; IMMUNOREACTIVITY; INTRACUTANEOUS TEST; MICROARRAY ANALYSIS; MILK ALLERGY; NONHUMAN; PEANUT ALLERGY; PHYSICAL TOLERANCE; PREDICTIVE VALUE; PRICK TEST; SENSITIVITY AND SPECIFICITY; SENSITIZATION; SHRIMP ALLERGY;

ALLERGENS; FOOD ANALYSIS; FOOD HYPERSENSITIVITY; HUMANS; IMMUNOGLOBULIN E; SKIN TESTS;

EID: 84872606333     PISSN: 15297322     EISSN: 15346315     Source Type: Journal    
DOI: 10.1007/s11882-012-0311-2     Document Type: Article

References (27)

1. •• Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(suppl):S1-58. National Institute of Allergy and Infectious Diseases sponsored consensus guidelines for the diagnosis and management of food allergy.
2. Chafen JJ, Newberry SJ, Riedl MA, et al. Diagnosing and managing common food allergies: a systematic review. JAMA. 2010;303:1848-56.
3. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638-46. (Pubitemid 47334837)
4. Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009;124:1549-55.
5. Sicherer SH, Muñoz-Furlong A, Godbold JH, Sampson HA. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow up. J Allergy Clin Immunol. 2010;125:1322-6.
6. Lieberman JA, Cox AL, Vitale M, Sampson HA. Outcomes of office-based, open food challenges in the management of food allergy. J Allergy Clin Immunol. 2011;128:1120-2.
7. Ott H, Baron JM, Heise R, et al. Clinical usefulness of microarray-based IgE detection in children with suspected food allergy. Allergy. 2008;63:1521-8.
8. D'Urbano LE, Pellegrino K, Artesani MC, et al. Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy. Clin Exp Allergy. 2010;40:1561-70.
9. Alessandri C, Zennaro D, Scala E, et al. Ovomucoid (Gal d 1) specific IgE detected by microarray system predict tolerability to boiled hen's egg and an increased risk to progress to multiple environmental allergen sensitisation. Clin Exp Allergy. 2012;42:441-50.
10. Caubet JC, Bencharitiwong R, Moshier E, et al. Significance of ovomucoid- and ovalbumin-specific IgE/IgG(4) ratios in egg allergy. J Allergy Clin Immunol. 2012;129:739-47.
11. Lemon-Mulé H, Sampson HA, Sicherer SH, et al. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol. 2008;122:977-83.
12. • Nicolaou N, Poorafshar M, Murray C, et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol. 2010;125:191-7. Excellent study demonstrating the lack of specificity of SPT and peanut sIgE in the diagnosis of peanut allergy, and identifying Ara h 2 as a key predictor of reactivity to peanut.
13. Koppelman SJ, Wensing M, Ertmann M, et al. Relevance of Ara h1, Ara h2 and Ara h3 in peanut-allergic patients, as determined by immunoglobulin E Western blotting, basophil-histamine release and intracutaneous testing: Ara h2 is the most important peanut allergen. Clin Exp Allergy. 2004;34:583-90. (Pubitemid 38534890)
14. Dang TD, Tang M, Choo S, et al. Increasing the accuracy of peanut allergy diagnosis by using Ara h 2. J Allergy Clin Immunol. 2012;129:1056-63.
15. Osborne NJ, Koplin JJ, Martin PE, et al. The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability. Clin Exp Allergy. 2010;40:1516-22.
16. Koppelman SJ, de Jong GA, Laaper-Ertmann M, et al. Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2. Clin Exp Allergy. 2005;35:490-7. (Pubitemid 40577243)
17. Asarnoj A, Glaumann S, Elfström L, et al. Anaphylaxis to peanut in a patient predominantly sensitized to Ara h 6. Int Arch Allergy Immunol. 2012;159:209-12.
18. Asarnoj A, Movérare R, Ostblom E, et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy. 2010;65:1189-95.
19. Movérare R, Ahlstedt S, Bengtsson U, et al. Evaluation of IgE antibodies to recombinant peanut allergens in patients with reported reactions to peanut. Int Arch Allergy Immunol. 2011;156:282-90.
20. • Asarnoj A, Nilsson C, Lidholm J, et al. Peanut component Ara h 8 sensitization and tolerance to peanut. J Allergy Clin Immunol. 2012;130:468-72. Large trial demonstrating that isolated sensitization to the peanut component Ara h 8 almost always indicates tolerance to peanuts.
21. Vetander M, Helander D, Lindquist C, et al. Classification of anaphylaxis and utility of the EAACI Taskforce position paper on anaphylaxis in children. Pediatr Allergy Immunol. 2011;22:369-73.
22. Gámez C, Sánchez-García S, Ibáñez MD, et al. Tropomyosin IgE-positive results are a good predictor of shrimp allergy. Allergy. 2011;66:1375-83.
23. Ortolani C, Ballmer-Weber BK, Hansen KS, et al. Hazelnut allergy; a double-blind, placebo-controlled food challenge multicenter study. J Allergy Clin Immunol. 2000;105:577-81. (Pubitemid 30169919)
24. Flinterman AE, Hoekstra MO, Meijer Y, et al. Clinical reactivity to hazelnut in children: association with sensitization to birch pollen or nuts? J Allergy Clin Immunol. 2006;118:1186-9. (Pubitemid 44666991)
25. Flinterman AE, Akkerdaas JH. den Hartog Jager CF, et al. Lipid transfer protein-linked hazelnut allergy in children from a non-Mediterranean birch-endemic area. J Allergy Clin Immunol. 2008;121:423-8. (Pubitemid 351215180)
26. Sicherer SH, Dhillon G, Laughery KA, et al. Caution: the Phadia hazelnut ImmunoCAP (f17) has been supplemented with recombinant Cor a 1 and now detects Bet v 1-specific IgE, which leads to elevated values for persons with birch pollen allergy. J Allergy Clin Immunol. 2008;122:413-4.
27. Phadia Immunology Reference Laboratory. Available at: http://www.pirllab.com/. Accessed August 19, 2012.