Mechanistic study of the covalent loading of paclitaxel via disulfide linkers for controlled drug release

Langmuir

Volumn 29, Issue 2, 2013, Pages 734-743

  Yuan, Li ^a   Chen, Wulian ^a   Hu, Jianhua ^a   Zhang, Jin Z ^b   Yang, Dong ^a  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER DRUG; CANCER CELLS; CARBOXYL GROUPS; CELLULAR PROLIFERATIONS; CONTROLLED DRUG RELEASE; CYTOTOXIC; DRUG RELEASE; DRUG-DELIVERY SYSTEMS; GLUTATHIONE CONCENTRATION; GLUTATHIONES; HELA CELL; HELA CELL LINE; IN-VITRO EVALUATION; INTRACELLULAR DRUG DELIVERY; MECHANISTIC STUDIES; MESOPOROUS SILICA NANOPARTICLES; MONOESTERS; NANO SCALE; PACLITAXEL; PRODRUGS; RELEASE BEHAVIORS; SIDE EFFECT; TUMOR CELLS;

CELL CULTURE; CELL PROLIFERATION; CYTOTOXICITY; DRUG DELIVERY; DRUG PRODUCTS; PEPTIDES; SULFUR COMPOUNDS;

LOADING;

ANTINEOPLASTIC AGENT; CALCIUM DERIVATIVE; CALCIUM SILICATE; DISULFIDE; GLUTATHIONE; PACLITAXEL; PRODRUG; SILICATE;

ARTICLE; CELL PROLIFERATION; CHEMISTRY; CONFOCAL MICROSCOPY; DELAYED RELEASE FORMULATION; DOSE RESPONSE; DRUG EFFECT; DRUG FORMULATION; FLUORESCENCE; HELA CELL; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL TRANSPORT; CALCIUM COMPOUNDS; CELL PROLIFERATION; DELAYED-ACTION PREPARATIONS; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; FLUORESCENCE; GLUTATHIONE; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; OXIDATION-REDUCTION; PACLITAXEL; PRODRUGS; SILICATES;

EID: 84872594159     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/la304324r     Document Type: Article

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