Glycemic control and chronic dosing of rhesus monkeys with a fusion protein of iduronidase and a monoclonal antibody against the human insulin receptor

Drug Metabolism and Disposition

Volumn 40, Issue 10, 2012, Pages 2021-2025

  Boado, Ruben J ^a,b   Hui, Eric Ka Wai ^b   Lu, Jeff Zhiqiang ^b   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ArmaGen Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS AFFECTING METABOLISM; AGT 181; GLUCOSE; HUMAN INSULIN RECEPTOR MONOCLONAL ANTIBODY ALPHA LEVO IDURONIDASE FUSION PROTEIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID LEVEL; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENCY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPOGLYCEMIA; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SEX DIFFERENCE; TOXICITY TESTING; TREATMENT DURATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD GLUCOSE; BLOOD-BRAIN BARRIER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENZYME REPLACEMENT THERAPY; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIA; IDURONIDASE; INFUSIONS, INTRAVENOUS; MACACA MULATTA; MALE; MUCOPOLYSACCHARIDOSIS I; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

EQUIDAE; MACACA MULATTA;

EID: 84866457004     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046375     Document Type: Article

References (16)

1. Bhaskar V, Goldfine ID, Bedinger DH, Lau A, Kuan HF, Gross LM, Handa M, Maddux BA, Watson SR, Zhu S, et al. (2012) A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control. Diabetes 61:1263-1271.
2. Boado RJ, Hui EK, Lu JZ, and Pardridge WM (2009) AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys. J Biotechnol144:135-141.
3. Boado RJ, Hui EK, Lu JZ, Zhou QH, and Pardridge WM (2011) Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein. MolPharm 8:1342-1350.
4. Boado RJ, Zhang Y, Zhang Y, Xia CF, Wang Y, and Pardridge WM (2008) Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier. Biotechnol Bioeng 99:475-484. (Pubitemid 351158294)
5. Brady RO and Schiffmann R (2004) Enzyme-replacement therapy for metabolic storage disorders. Lancet Neurol 3:752-756. (Pubitemid 39535261)
6. Brunetti A, Maddux BA, Wong KY, Hofmann C, Whittaker J, Sung C, and Goldfine ID (1989) Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected 3T3/HIR fibroblasts without activating receptor kinase. Biochem Biophys ResCommun 165:212-218. (Pubitemid 20012477)
7. Davis TM, Brown AE, and Smith CD (1993) Metabolic disturbances in Plasmodium coatneyi-infected rhesus monkeys. Int J Parasitol 23:557-563.
8. Hasselbalch SG, Knudsen GM, Videbaek C, Pinborg LH, Schmidt JF, Holm S, and Paulson OB (1999) No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 48:1915-1921. (Pubitemid 29458352)
9. Malek R, Chong AY, Lupsa BC, Lungu AO, Cochran EK, Soos MA, Semple RK, Balow JE, and Gorden P (2010) Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies. J Clin Endocrinol Metab 95:3641-3647.
10. Miebach E (2005) Enzyme replacement therapy in mucopolysaccharidosis type I. Acta PaediatrSuppl 94:58-60.
11. Pardridge WM and Boado RJ (2009) Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery. PharmRes 26:2227-2236.
12. Pardridge WM, Eisenberg J, and Yang J (1985) Human blood-brain barrier insulin receptor. J Neurochem 44:1771-1778. (Pubitemid 15000282)
13. Pardridge WM, Kang YS, Buciak JL, and Yang J (1995) Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm Res 12:807-816.
14. Powers WJ (1981) Cerebrospinal fluid to serum glucose ratios in diabetes mellitus and bacterial meningitis. Am J Med 71:217-220.
15. Wraith JE (2001) Enzyme replacement therapy in mucopolysaccharidosis type I: progress and emerging difficulties. J Inherit Metab Dis 24:245-250.
16. Zhou QH, Boado RJ, Lu JZ, Hui EK, and Pardridge WM (2012) Brain-penetrating IgG-iduronate 2-sulfatase fusion protein for the mouse. Drug Metab Dispos 40:329-335.