Subacute oral toxicity study of a new type of cordyceps, Paecilomyces sinclairii, in sprague-dawley rats

Toxicological Research

Volumn 25, Issue 2, 2009, Pages 101-106

  Kwack, Seung Jun ^a   Lee, Byung Mu ^b  

^a National Institute of Toxicological Research   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

2 week oral toxicity; Paecilomyces sinclairii; Sprague Dawley rats

Indexed keywords

EID: 84872572357     PISSN: 19768257     EISSN: 22342753     Source Type: Journal    
DOI: 10.5487/TR.2009.25.2.101     Document Type: Article

References (24)

1. Ahn, M.Y., Kang, S.C., Jung, N.J., Koo, H.J., Kwack, S.J., Yoo, E.J., Jung, J.A., Ko, J.K., Ryu, K.S., Jee, S.D., Lee, Y.W. and Lee, B.M. (2003). Acute oral toxicity of Paecilomyces sinclairii in beagle dogs. J. Toxicol. Pub. Health, 19, 241-245.
2. Furuya, T., Hirotani, M. and Matsuzawa, M. (1983). N6-(2-hydroxyethyl)adenosine, a biologically active compound from cultured mycelia of cordyceps and isaria species. Phytochem., 22, 2509-2512.
3. Fujino, M., Li, X.K., Kitazawa, Y., Guo, L., Kawasaki, M., Funeshima, N., Amano, T. and Suzuki, S. (2002). Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-fas antibody I human T-lymphoma cell line (jurkat cells). J. Pharmacol. Exp. Ther., 300, 939-945.
4. Fujino, M., Li, X.K., Guo, L., Amano, T. and Suzuki, S. (2001). Activation of caspases and mitochondria in FTY720-mediated apoptosis in human T cell line Jurkat. Int. Immunopharmacol., 1, 2011-2021.
5. Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki., H. and Mouri, T. (1991). Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria. Yakugaku Zasshi, 111, 504-509.
6. Kanki, K., Nishikawa, A., Furukawa F., Kitamura, Y., Imazawa, T., Umemura, T. and Hirose, M. (2003). A 13-week subchronic toxicity study of paprika color in F344 rats. Food Chem. Toxicol., 41, 1337-1343.
7. Kiho, T., Hui, J., Yamane, A. and Ukai, S. (1993). Polysaccharides in fungi. XXXII. Hypoglycemic activity and chemical properties of a polysaccharide from the cultural mycelium of Cordyceps sinensis. Biol. Pharm. Bull., 16, 1291-1293, 1993.
8. Kiho, T., Yamane, A., Hui, J. and Ukai, S. (1996). Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol. Pharm. Bull., 19, 294-296.
9. Kim, H.S., Lee, S.K., Kim, K.B., Kwack, S.J., Ahn, M.Y., Choi, B.C. and Lee, B.M. (1996). Acute oral toxicity of KDRD-002 in rats. J. Appl. Pharmacol., 4, 310-313.
10. Kim, H.S., Park, S.M., Kim, Y.K., Byun, S.H., Yun, J.D., Yu, Y.H., Lee, H.W. and Lee, B.M. (1993). Acute toxicity of DWH-01 (Ranitidine : Bithmuth Subcitrate : Sucralfate) in rats. J. Appl. Pharmacol., 2, 262-265.
11. Kim, S.W., Hwang, H.J., Xu, C.P., Choi, J.W. and Yun, J.W. (2003). Effect of aeration and agitation on the production of mycelial biomass and exopolysaccharides in an enthomopathogenic fungus Paecilomyces sinclairii. Lett. Appl. Microbiol., 36, 321-326.
12. Kitamura Y., Nishikawa, A., Furukawa, F., Nakamura, H., Okazaki, K., Umemura, T., Imazawa, T. and Hirose, M. (2003). A subchronic toxicity study of shea nut color in Wistar rats. Food Chem. Toxicol., 41, 1537-1542.
13. Kuo, Y.C., Lin, C.Y., Tsai, W.J., Wu, C.L., Chen, C.F. and Shiao, M.S. (1994). Growth inhibitors against tumor cells in Cordyceps sinensis other than cordycepin and polysaccharides. Cancer Invest., 12, 611-615.
14. Kwack, S.J., Chun, S.A., Lim, S.Y., Park, H.S., Hong, C.Y., Kim, W.B. Kim, B.M., Ahn, B.O. and Lee, B.M. (1996). Acute toxicity study of recombinant human erythropoietin(rHu-EPO) in rats. Journal of Applied Pharmacology, 4, 330-333.
15. Landsdown, A.B. (1993). Animal husbandry. In: Anderson, D. (Ed.), Experimental Toxicoloy, the Basic Issues. BIBRA, Surrey, UK, p. 101. RSC Publishing.
16. Litchfield, J.T., Jr. and Wilcoxon, F. (1949). A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther., 96, 99-113.
17. Liu, X.Y., Wu, C.Z. and Li, C.C. (1991). Antioxidation of Paecilomyces sinensis (S. pnov.). Chin. J. Trad. Med., 4, 289-303.
18. Long, G., Symanowski, T. and Roback, K. (1998). Precision in data acquisition and reporting of organ weight in rats and mice. Toxicol. Pathol., 26, 316-318.
19. Lorke, D. (1983). A new approach to practical toxicity testing. Arch. Toxicol., 54, 275-287.
20. Mellert, W., Deckardt K., Gembardt, C., Schulte S., Ravenzwaay B.V. and Slesinski, R.S. (2002). Thirteen-week oral toxicity study of synthetic lycopene products in rats. Food Chem. Toxicol., 40, 1581-1588.
21. Oh, G.S., Hong, K.H., Oh, H., Pae, H.O., Kim, I.K., Kim, N.Y., Kwon, T.O., Shin, M.K. and Chung, H.T. (2001). 4-Acetyl- 12,13-epoxyl-9-trichothecene-3,15-diol isolated from the frutiting bodies of Isaria japonica Yasuda induces apoptosis of human leukemia cells (HL-60). Biol. Pharm. Bull., 24, 785-789.
22. Rehg, J.E. and Toth, L.A. (1998). Rodent quarantine programs: purpose, principles and practice. Laboratory Animals in Science, 48, 438-447.
23. Schlede, E., Mischke, U., Diener, W. and Kayser, D. (1995). The international validation study of the acute toxic class method (oral). Arch. Toxicol., 69, 659-670.
24. Shin, K.H., Lim, S.S., Lee, S.H., Lee, Y.S., Jung, S.H. and Cho, S.Y. (2003). Anti-tumor and immuno-stimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps spp. Phytother. Res., 17, 830-833.