Triterpenoids from Ganoderma lucidum and their cytotoxic activities

Natural Product Research

Volumn 27, Issue 1, 2013, Pages 17-22

  Li, Peng ^a   Deng, Yan Ping ^a   Wei, Xiao Xia ^a   Xu, Jian Hua ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

cytotoxic activity; Ganoderma lucidum; triterpenoid

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; ETHYL 7BETA HYDROXY 4,4,14ALPHA TRIMETHYL 3,11,15 TRIOXO 5ALPHA CHOL 8 EN 24 OATE; GANODERMA LUCIDUM EXTRACT; GANODERMANONDIOL; LUCIDUMOL; METHYL LUCIDENATE DERIVATIVE; SILICA GEL; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; FRUITING BODY; GANODERMA LUCIDUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; HEP G2 CELLS; HL-60 CELLS; HUMANS; MOLECULAR STRUCTURE; REISHI; TRITERPENES;

GANODERMA LUCIDUM;

EID: 84872570412     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2011.652961     Document Type: Article

References (16)

1. 13C-NMR assignments of lanostanoids from Ganoderma lucidum by 2D-NMR studies. Journal of Natural Products, 51, 54-59.
2. Chang, R. (1996). Functional properties of edible mushrooms. Nutrition Reviews, 54, 91-93.
3. Chen, T.K., Ales, D.C., Baenziger, N.C., & Wiemer, D.F. (1983). Anti-repellent triterpenoids from Cordia alliodora. The Journal of Organic Chemistry, 48, 3525-3531.
4. Chen, Y., Xie, M.Y., & Gong, X.F. (2007). Microwave-assisted extraction used for the isolation of total triterpenoid saponins from Ganoderma atrum. Journal of Food Engineering, 81, 162-170.
5. Chen, R.Y., & Yu, D.Q. (1990). Advances of triterpenoids constituents of Ganoderma lucidum. Acta Pharmaceutica Sinica, 25, 940-953.
6. Gao, Y.H., & Zhou, S.F. (2004). Chemopreventive and tumoricidal properties of Lingzhi mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromy cetideae). Part II. Mechanism considerations (review). International Journal of Medicinal Mushrooms, 6, 219-230.
7. Hong, K.J., Dunn, D.M., Shen, C.L., & Pence, B.C. (2004). Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells. Phytotherapy research, 18, 768-770.
8. Jong, S.C., & Birmingham, J.M. (1992). Medicinal benefits of the mushroom Ganoderma. Advances in Applied Microbiology, 37, 101-134.
9. Kikuchi, T., Kanomi, S., Kadota, S., Murai, Y., Tsubono, K., & Ogita, Z. (1986). Constituents of fungus Ganoderma lucidum (FR.) KARST. I. Structures of ganoderic acids C2, E, I, and K, lucidenic acid F and related compounds. Chemical and Pharmaceutical Bulletin, 34, 3695-3712.
10. Lin, Z.B., & Zhang, H.N. (2004). Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacologica Sinica, 25, 1387-1395.
11. Liu, G.Q., & Zhang, K.C. (2005). Mechanisms of the anticancer action of Ganoderma lucidum (Leyss. ex Fr.) Karst: s new understanding. Journal of Integrative Plant Biology, 47, 129-135.
12. Luo, J., & Lin, Z.B. (2002). Advances of pharmacological effects of triterpenes from Ganoderma lucidum. Acta Pharmaceutica Sinica, 37, 574-578.
13. Stanley, G., Harvey, K., Slivova, V., Jiang, J., & Sliva, D. (2005). Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-/31 from prostate cancer cells. Biochemical and Biophysical Research Communications, 330, 46-52.
14. Wang, M.Y., Liu, Q., Che, Q.M., & Lin, Z.B. (2000). Effects of G. lucidum triterpenoids on three animal liver-injury models. Acta Pharmaceutica Sinica, 35, 326-329.
15. Yuen, J.W.M., & Gohel, M.D.I. (2005). Anticancer effects of Ganoderma lucidum: a review of scientific evidence. Nutrition and Cancer, 53, 11-17.
16. Zhu, M., Chang, Q., Wong, L.K., Chong, F.S., & Li, R.C (1999). Triterpene antioxidants from Ganoderma lucidum. Phytotherapy Research, 13, 529-531.