Mechanisms of the anticancer action of Ganoderma lucidum (Leyss. ex Fr.) Karst.: A new understanding

Journal of Integrative Plant Biology

Volumn 47, Issue 2, 2005, Pages 129-135

  Liu, Gao Qiang ^a,b   Zhang, Ke Chang ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY   (China)

Author keywords

Anticancer activity; Ganoderma lucidum (Leyss. ex Fr.) Karst.; Mechanism of action; Medicinal plant; Polysaccharides; Triterpenoids

Indexed keywords

MEDICINAL PLANT;

FUNGI; GANODERMA LUCIDUM;

EID: 22744436323     PISSN: 16729072     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1744-7909.2005.00037.x     Document Type: Review

References (38)

1. Cao LZ, Lin ZB (2002). Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides. Immunol Lett 83, 163-169.
2. Cao LZ, Lin ZB (2003). Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro. Acta Pharmacol Sin 24, 321-326.
3. Casson AG, Zheng Z, Chiasson D et al. (2003). Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma. Cancer Detect Prev 27, 139-146.
4. Cheung WMW, Hui WS, Chu PWK, Chin SW, Ip NY (2000). Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett 486, 291-296.
5. Chung WT, Lee SH, Kim JD et al. (2001). Effect of mycelial culture broth of Ganoderma lucidum on the growth characteristics of human cell lines. J Biosci Bioeng 92, 550-555.
6. Furusawa E, Chou SC, Furusawa S, Hirazum A, Dang Y (1992). Antitumor activity of Ganoderma lucidum, an edible mushroom, on intraperitoneally implanted Lewis lung carcinoma in synergenic mice. Phytother Res 6, 300-304.
7. Gao JJ, Min BS, Ahn EM, Nakamura N, Lee HK, Hattori M (2002a). New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. Chem Pharm Bull 50, 837-840.
8. Gao YH, Zhou SF, Chen GL, Dai XH, Ye JX (2002b). A phase I/II study of a Ganoderma lucidum extract (Ganopoly) in patients with advanced cancer. Int J Med Mushroom 4, 207-214.
9. Gao YH, Zhou SF, Jiang WQ, Huang M, Dai XH (2003). Effects of Ganopoly(R) (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest 32, 201-215.
10. Ha TBT, Gerhauser C, Zhang WD, Ho-Chong-Line N, Fouraste I (2000). New lanostanoids from Ganoderma lucidum that induce NAD(P)H: quinone oxidoreductase in cultured hepalclc7 murine hepatoma cells. Planta Med 66, 681-684.
11. Hitoshi I, Sensuke N, Keishiro S (1977). Studies on antitumor activity of basidiomycete polysaccharides VII. Antitumor effect of the polysaccharide preparation from Ganoderma lucidum on mouse sarcoma 180. Mie J 26, 147-152.
12. Hsieh C, Yang FC (2004). Reusing soy residue for the solid-state fermentation of Ganoderma lucidum. Bioresource Technol 91, 105-109.
13. Hyun JW, Choi EC, Kim BK (1990). Studies on constituents of higher fungi of Korea IXII. Antitumor components of the basidiocarp of Ganoderma lucidum. Korean J Mycol 18, 58-69.
14. Hwang SF, Liu KJ, Kuan YH, Tung KS, Su CH, Tung TC (1989). The inhibitory effect on artificial pulmonary metastasis of murine S-180 sarcoma cells by orally administered Ganoderma lucidum culture broth. J Chin Oncol Soc 5, 10-15.
15. Kao YH, Yu CL, Chang LW (2003). Low concentrations of arsenic induce vascular endothelial growth factor and nitric oxide release and stimulate angiogenesis in vitro. Chem Res Toxicol 16, 460-468.
16. Kim HS, Kacew S, Lee BM (1999). In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis 20, 1637-1640.
17. Kimura Y, Taniguchi M, Baba K (2002). Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: Mechanism of action and isolation of an active substance. Anticancer Res 22, 3309-3318.
18. Kwon NS, Nathan CF, Gilker C, Griffith OW, Matthews DE, Stuehr DJ (1990). L-Citrulline production from L-arginine by macrophage nitric oxide synthase: The ureido oxygen derives from dioxygen. J Biol Chem 265, 13442-13445.
19. Lan J, Yang JS, Xu JT (1999). Resources and utilization of anticarciogenic medical fungi. J Chin Med Mat 22, 614-618 (in Chinese with an English abstract).
20. Li PZ, Zhang KC (2000). Isolation, purification and bioactivities of exopolysaccharides from fermented broth of Ganoderma lucidum. Acta Microbiol Sin 40, 217-220 (in Chinese with an English abstract).
21. Lin ZB (2002). Progress of studies on the anti-tumor activity and immunomodulating effects of Ganoderma. J Peking Univ (Health Sci) 34, 493-498 (in Chinese with an English abstract).
22. Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H (2002). Prevention of development of N,N'-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia in male ICR mice. Int J Mol Med 9, 113-117.
23. Mazar AP (2001). The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer. Anticancer Drugs 12, 387-400.
24. Min BS, Gao JJ, Nakamura N, Hattori M (2000). Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against Meth-A and LLC tumor cells. Chem Pharm Bull 48, 1026-1033.
25. Odekon LE, Sato Y, Rifkin D (1992). Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity. J Cell Physiol 150, 258-263.
26. Reddya L, Odhava B, Bhoolab KD (2003). Natural products for cancer prevention: A global perspective. Pharmacol Ther 99, 1-13.
27. Sliva D, Labarrere C, Slivova V, Sedlak M, Jr FPL, Ho NWY (2002). Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochem Biophys Res Commun 298, 603-612.
28. Song YS, Kim SH, Sa JH, Jin C, Lim CH, Park EH (2004). Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum. J Ethnophamacol 90, 17-20.
29. Teow SS (1997). The effective application of Ganoderma nutriceuticals. In: Kim BK, Moon CK, Kim TS, eds. Recent Progress in Ganoderma lucidum Research. The Pharmaceutical Society of Korea, Seoul. pp. 21-39.
30. Wang AC, Li B (2002). Ganoderma. Beijing Science and Technology Press, Beijing (in Chinese).
31. Wang SY, Hsu ML, Hsu HC et al. (1997). The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer 70, 699-705.
32. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH (2002). Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides: Functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorgan Med Chem 10, 1057-1062.
33. Wu TS, Shi LS, Kuo SC (2001). Cytotoxicity of Ganoderma lucidum triterpenes. J Nat Prod 64, 1121-1122.
34. Yang HL, Zhang KC (2002). The relationship between molecular structure and activity of Ganoderma acids. J Wuxi Univ Light Ind 21, 249-253 (in Chinese with an English abstract).
35. Zhang QH, Lin ZB (1999a). The antitumor activity of Ganoderma lucidum (Curt. Fr.) P. Karst. (Ling Zhi) (Aphyllophoromycetideae) polysaccharides is related to tumor necrosis factor-α and interferon-γ. Int J Med Mushrooms 1, 207-215.
36. Zhang QH, Lin ZB (1999b). Effect of Ganoderma lucidum polysaccharides B on TNF-α and IFN-γ production and their mRNA expression. J Beijing Med Univ 31, 179-183 (in Chinese with an English abstract).
37. Zhang X, Jia YM, Li Q, Niu SF, Zhu SN, Sen CF (2000). Clinical curative effect investigation of Lingzhi tablets on lung cancer. Chin Trad Patent Med 22, 486-488 (in Chinese with an English abstract).
38. Zhu HS, Yang XL, Wang LB, Zhao DX, Chen L (2000). Effects of extracts from sporoderm-broken spores of Ganoderma lucidum on HeLa cells. Cell Biol Toxicol 16, 201-206.