Inhalation therapy of calcitonin relieves osteoarthritis of the Knee

Journal of Korean Medical Science

Volumn 27, Issue 11, 2012, Pages 1405-1410

  Armagan, Onur ^a   Serin, Dilek Kaya ^b   Calisir, Cüneyt ^a   Dokumacioglu, Ali ^a   Ozgen, Merih ^a   Oner, Setenay ^a   Alatas, Ozkan ^a  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^b Eskisehir State Hospital   (Turkey)

Author keywords

Exercise; Knee osteoarthritis; Nasal salmon calcitonin

Indexed keywords

BONE DENSITY CONSERVATION AGENT; CALCITONIN; COLLAGEN II C TELOPEPTIDE; COLLAGEN II C-TELOPEPTIDE; COLLAGEN TYPE 2; INTERLEUKIN 1BETA; NITRIC OXIDE; PEPTIDE FRAGMENT; SALCATONIN; STROMELYSIN;

AGED; ARTICLE; ARTIFICIAL VENTILATION; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; KINESIOTHERAPY; KNEE OSTEOARTHRITIS; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; URINE; WALKING;

AGED; BONE DENSITY CONSERVATION AGENTS; CALCITONIN; COLLAGEN TYPE II; EXERCISE THERAPY; FEMALE; HUMANS; INTERLEUKIN-1BETA; MAGNETIC RESONANCE IMAGING; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; NITRIC OXIDE; OSTEOARTHRITIS, KNEE; PEPTIDE FRAGMENTS; RESPIRATORY THERAPY; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; WALKING;

EID: 84872564026     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2012.27.11.1405     Document Type: Article

References (30)

1. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010; 6: 625-35.
2. Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002; 39: 237-46.
3. Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Hellio Le Graverand MP, Degroot J, Slagboom PE. Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study. Ann Rheum Dis 2006; 65: 360-5.
4. Hayami T, Pickarski M, Wesolowski GA, McLane J, Bone A, Destefano J. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum 2004; 50:1193-206
5. Karsdal MA, Tanko LB, Riis BJ, Sondergard BC, Henriksen K, Altman RD, Qvist P, Christiansen C. Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA? Osteoarthritis Cartilage 2006; 14: 617-24.
6. Manicourt DH, Altman RD, Williams JM, Devogelaer JP, Druetz-Van Egeren A, Lenz ME, Pietryla D, Thonar EJ. Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions. Arthritis Rheum 1999; 42: 1159-67.
7. Sondergaard BC, Wulf H, Henriksen K, Schaller S, Oestergaard S, Qvist p, Tankó LB, Bagger YZ, Christiansen C, Karsdal MA. Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes. Osteoarthritis Cartilage 2006; 14: 759-68.
8. Sondergaard BC, Oestergaard S, Christiansen C, Tankó LB, Karsdal MA. The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model. Arthritis Rheum 2007; 56: 2674-8.
9. Manicourt DH, Azria M, Mindeholm L, Thonar EJ, Devogelaer JP. Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. Arthritis Rheum 2006; 54: 3205-11.
10. Lyritis GP, Paspati I, Karachalios T, Ioakimidis D, Skarantavos G, Lyritis PG. Pain Relief From Nasal Salmon Calcitonin I .n Osteoporotic Vertebral Crush Fractures. Acta Orthop Scand Suppl 1997; 275: 112-4.
11. Petrella RJ, Bartha C. Home based exercise therapy for older patients with knee osteoarthritis: a randomized clinical trial. J Rheumatol 2000; 27: 2215-21.
12. Evcik D, Sonel B. Effectiveness of a home-based exercise therapy and walking program on osteoarthritis of the knee. Rheumatol Int 2002; 22: 103-6.
13. Bredella MA, Tirman PF, Peterfy CG, Zarlingo M, Feller JF, Bost FW, Belzer JP, Wischer TK, Genant HK. Accuracy of T2-weighted fast spin-echo MR imaging with fat saturation in detecting cartilage defects in the knee: comparison with arthroscopy in 130 patients. AJR Am J Roentgen-ol 1999; 172: 1073-80.
14. van Baar ME, Dekker J, Lemmens JA, Oostendorp RA, Bijlsma JW. Pain and disability in patients with osteoarthritis of hip or knee: the relationship with articular, kinesiological and psychological characteristics. J Rheumatol 1998; 25: 125-33.
15. Ofluoglu D, Akyuz G, Unay O, Kayhan O. The effect of calcitonin on beta-endorphin levels in postmenopausal osteoporotic patients with back pain. Clin Rheumatol 2007; 26: 44-9.
16. Takayama B, Kikuchi S, Konno S, Sekiguchi M. An immunohistochemical study of the antinociceptive effect of calcitonin in ovariectomized rats. BMC Musculoskelet Disord 2008; 9: 164.
17. Ito A, Kumamoto E, Takeda M, Shibata K, Sagai H, Yoshimura M. Mechanisms for ovariectomy-induced hyperalgesia and its relief by calcitonin: participation of 5-HT1A-like receptor on C-afferent terminals in substantia gelatinosa of the rat spinal cord. J Neurosci 2000; 20: 6302-8.
18. Badurski J, Jeziernicka E, Naruszewicz K, Racewicz A. Comparative analysis of three treatment regimens for treating gonarthritis with calcitonin, naproxen and flavonoids based on EULAR criteria and visual analogue scale (VAS). Pol Tyg Lek 1995; 50: 37-40.
19. Suzuki H, Nakamura I, Takahashi N, Ikuhara T, Matsuzaki K, Isogai Y, Hori M, Suda T. Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts. Endocrinology 1996; 137: 4685-90.
20. Shyu JF, Shih C, Tseng CY, Lin CH, Sun DT, Liu HT, Tsung HC, Chen TH, Lu RB. Calcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activities. Bone 2007; 40: 1329-42.
21. Franchimont P, Bassleer C, Henrotin Y, Gysen P, Bassleer R. Effects of human and salmon calcitonin on human articular chondrocytes cultivated in clusters. J Clin Endocrinol Metab 1989; 69: 259-66.
22. Sondergaard BC, Madsen SH, Segovia-Silvestre T, Paulsen SJ, Christiansen T, Pedersen C, Bay-Jensen AC, Karsdal MA. Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes. BMC Musculoskelet Disord 2010; 11: 62.
23. Di Nino DL, Linsenmayer TF. Positive regulation of endochondral cartilage growth by perichondrial and periosteal calcitonin. Endocrinology 2003; 144: 1979-83.
24. Karsdal MA, Leeming DJ, Dam EB, Henriksen K, Alexandersen P, Pastoureau P. Should subchondral bone turnover be targeted when treating osteoarthritis? Osteoarthritis Cartilage 2008; 16: 638-46.
25. Reijman M, Hazes JM, Bierma-Zeinstra SM, Koes BW, Christgau S, Christiansen C, Uitterlinden AG, Pols HA. A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum 2004; 50: 2471-8.
26. Meulenbelt I, Kloppenburg M, Kroon HM, Houwing-Duistermaat JJ, Garnero P, Hellio-Le Graverand MP, DeGroot J, Slagboom PE. Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study. Osteoarthritis Cartilage 2007; 15: 379-85
27. Bagger YZ, Tankó LB, Alexandersen P, Karsdal MA, Olson M, Minde-holm L, Azria M, Christiansen C. Oral salmon calcitonin induced suppression of urinary collogen type II degradation in postmenapausal women: A new potential treatment of osteoarthritis. Bone 2005; 37: 425-30
28. Karsdal MA, Byrjalsen I, Henriksen K, Riis BJ, Lau EM, Arnold M, Christiansen C. The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study. Osteoarthritis Cartilage 2010; 18: 150-9
29. Lotz M. The role of nitric oxide in articular cartilage damage. Rheum Dis Clin North Am 1999; 25: 269-82
30. Dam EB, Byrjalsen I, Karsdal MA, Qvist P, Christiansen C. Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI. Osteoarthritis Cartilage 2009; 17: 384-9