메뉴 건너뛰기




Volumn 33, Issue SUPPL. 1, 2013, Pages

AD gene 3-D: Moving past single layer genetic information to map novel loci involved in Alzheimer's disease

Author keywords

Alzheimer's disease; eQTL; expression quantitative trait locus; gene expression; gene expression regulation; genetic; genetic predisposition to disease; human brain; transcription

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; PRESENILIN 1; PRESENILIN 2; TAU PROTEIN;

EID: 84872526808     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-129013     Document Type: Review
Times cited : (5)

References (44)
  • 4
    • 0034895326 scopus 로고    scopus 로고
    • The genetics of late-onset Alzheimer's disease
    • Myers AJ, Goate AM (2001) The genetics of late-onset Alzheimer's disease. Curr Opin Neurol 14, 433-440
    • (2001) Curr Opin Neurol , vol.14 , pp. 433-440
    • Myers, A.J.1    Goate, A.M.2
  • 6
    • 78651363397 scopus 로고    scopus 로고
    • Linkage to the 8p21.1 region Including the CLU gene in age at onset stratified alzheimer's disease families
    • Sillen A, Lilius L, Forsell C, Kimura T, Winblad B, Graff C (2011) Linkage to the 8p21.1 region Including the CLU gene in age at onset stratified alzheimer's disease families. J Alzheimers Dis 23, 13-20
    • (2011) J Alzheimers Dis , vol.23 , pp. 13-20
    • Sillen, A.1    Lilius, L.2    Forsell, C.3    Kimura, T.4    Winblad, B.5    Graff, C.6
  • 9
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants atCLUandCR1associated with Alzheimer's disease
    • European Alzheimer's Disease Initiative I De Pancorbo MM Lendon C Dufouil C Jaillard C Leveillard T Alvarez V Bosco P Mancuso M Panza F Nacmias B Bossu P Piccardi P Annoni G Seripa D Galimberti D Hannequin D Licastro F Soininen H Ritchie K Blanche H Dartigues JF Tzourio C Gut I Van Broeckhoven C Alperovitch A Lathrop M Amouyel P.
    • Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fievet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, European Alzheimer's Disease Initiative I, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossu P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanche H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alperovitch A, Lathrop M, Amouyel P (2009) Genome-wide association study identifies variants atCLUandCR1associated with Alzheimer's disease. Nat Genet 41, 1094-1099
    • (2009) Nat Genet , vol.41 , pp. 1094-1099
    • Lambert, J.C.1    Heath, S.2    Even, G.3    Campion, D.4    Sleegers, K.5    Hiltunen, M.6    Combarros, O.7    Zelenika, D.8    Bullido, M.J.9    Tavernier, B.10    Letenneur, L.11    Bettens, K.12    Berr, C.13    Pasquier, F.14    Fievet, N.15    Barberger-Gateau, P.16    Engelborghs, S.17    De Deyn, P.18    Mateo, I.19    Franck, A.20    more..
  • 10
    • 79957604912 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: New evidences for an old hypothesis?
    • Lambert JC, Amouyel P (2011) Genetics of Alzheimer's disease: New evidences for an old hypothesis? Curr Opin Genet Dev 21, 295-301
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 295-301
    • Lambert, J.C.1    Amouyel, P.2
  • 11
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12, 383-388
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 17
    • 27644482314 scopus 로고    scopus 로고
    • Mapping determinants of human gene expression by regional and genome-wide association
    • Cheung VG, Spielman RS, Ewens KG, Weber TM, Morley M, Burdick JT (2005) Mapping determinants of human gene expression by regional and genome-wide association. Nature 437, 1365-1369
    • (2005) Nature , vol.437 , pp. 1365-1369
    • Cheung, V.G.1    Spielman, R.S.2    Ewens, K.G.3    Weber, T.M.4    Morley, M.5    Burdick, J.T.6
  • 25
    • 27844454448 scopus 로고    scopus 로고
    • Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits
    • Schadt EE (2005) Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits. Curr Opin Biotechnol 16, 647-654
    • (2005) Curr Opin Biotechnol , vol.16 , pp. 647-654
    • Schadt, E.E.1
  • 27
    • 45849117641 scopus 로고    scopus 로고
    • Statistical power of expression quantitative trait loci for mapping of complex trait loci in natural populations
    • Schliekelman P (2008) Statistical power of expression quantitative trait loci for mapping of complex trait loci in natural populations. Genetics 178, 2201-2216
    • (2008) Genetics , vol.178 , pp. 2201-2216
    • Schliekelman, P.1
  • 28
    • 84862183179 scopus 로고    scopus 로고
    • The age of the "ome": Genome, transcriptome and proteome data set collection and analysis
    • doi: J.brainresbull.2011.11.015
    • Myers AJ (2011) The age of the "ome": Genome, transcriptome and proteome data set collection and analysis. Brain Res Bull, doi: J.brainresbull.2011.11.015
    • (2011) Brain Res Bull
    • Myers, A.J.1
  • 35
    • 38949175007 scopus 로고    scopus 로고
    • A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    • Miller JA, Oldham MC, Geschwind DH (2008) A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J Neurosci 28, 1410-1420
    • (2008) J Neurosci , vol.28 , pp. 1410-1420
    • Miller, J.A.1    Oldham, M.C.2    Geschwind, D.H.3
  • 36
    • 55049095941 scopus 로고    scopus 로고
    • Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases
    • Ray M, Ruan J, Zhang W (2008) Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases. Genome Biol 9, R148
    • (2008) Genome Biol , vol.9
    • Ray, M.1    Ruan, J.2    Zhang, W.3
  • 38
    • 23944458138 scopus 로고    scopus 로고
    • Ageneral framework for weighted gene co-expression network analysis
    • Article17
    • Zhang B, Horvath S (2005)Ageneral framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol 4, Article17
    • (2005) Stat Appl Genet Mol Biol , vol.4
    • Zhang, B.1    Horvath, S.2
  • 40
    • 77957296042 scopus 로고    scopus 로고
    • Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks
    • Ray M, Zhang W (2010) Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks. BMC Syst Biol 4, 136
    • (2010) BMC Syst Biol , vol.4 , pp. 136
    • Ray, M.1    Zhang, W.2
  • 41
    • 50949092459 scopus 로고    scopus 로고
    • Why do hubs in the yeast protein interaction network tend to be essential: Reexamining the connection between the network topology and essentiality
    • Zotenko E,Mestre J, O'Leary DP, Przytycka TM (2008) Why do hubs in the yeast protein interaction network tend to be essential: Reexamining the connection between the network topology and essentiality. PLoS Comput Biol 4, e1000140
    • (2008) PLoS Comput Biol , vol.4
    • Zotenko, E.1    Mestre, J.2    O'Leary, D.P.3    Przytycka, T.M.4
  • 42
    • 0034652249 scopus 로고    scopus 로고
    • An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-Like proteins
    • O'Regan S,Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (2000) An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-Like proteins. Proc Natl Acad Sci U S A 97, 1835-1840
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1835-1840
    • O'Regan, S.1    Traiffort, E.2    Ruat, M.3    Cha, N.4    Compaore, D.5    Meunier, F.M.6
  • 43
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • BartusRT, Dean RL III, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408-414
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean III, R.L.2    Beer, B.3    Lippa, A.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.