Digit (2D:4D) ratio is associated with muscle mass (MM) and strength (MS) in older adults: Possible effect of in utero androgen exposure

Archives of Gerontology and Geriatrics

Volumn 56, Issue 2, 2013, Pages 358-363

  Halil, Meltem ^a   Gurel, Esin Ileri ^a   Kuyumcu, Mehmet Emin ^a   Karaismailoglu, Serkan ^a   Yesil, Yusuf ^a   Ozturk, Zeynel Abidin ^b   Yavuz, Burcu Balam ^a   Cankurtaran, Mustafa ^a   Ariogul, Servet ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

Androgen; Digit ratio; Elderly; MM; MS; Testosterone

Indexed keywords

ANDROGEN;

AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; CALF CIRCUMFERENCE; CLINICAL ASSESSMENT; DIGIT RATIO; ELDERLY CARE; FEMALE; GRIP STRENGTH; HAND GRIP; HUMAN; INDEX FINGER; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MUSCLE MASS; MUSCLE STRENGTH; MUSCULOSKELETAL SYSTEM PARAMETERS; PRIORITY JOURNAL; SEX DIFFERENCE;

AGED; AGING; ANDROGENS; ANTHROPOMETRY; CROSS-SECTIONAL STUDIES; FEMALE; FINGERS; HAND STRENGTH; HUMANS; MALE; MATERNAL EXPOSURE; MUSCLE STRENGTH; TESTOSTERONE;

EID: 84872497800     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2012.11.003     Document Type: Article

References (29)

1. Bastiaanse L.P., Hilgenkamp T.I., Echteld M.A., Evenhuis H.M. Prevalence and associated factors of sarcopenia in older adults with intellectual disabilities. Research in Developmental Disabilities 2012, 33:2004-2012.
2. Chien M.Y., Huang T.Y., Wu Y.T. Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. Journal of the American Geriatrics Society 2008, 56:1710-1715.
3. Cohendy R., Rubenstein L.Z., Eledjam J.J. The Mini Nutritional Assessment-Short Form for preoperative nutritional evaluation of elderly patients. Aging 2001, 13:293-297.
4. Cruz-Jentoft A.J., Baeyens J.P., Bauer J.M., Boirie Y., Cederholm T., Landi F., et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing 2010, 39:412-423.
5. Evardone M., Alexander G.M. Anxiety, sex-linked behaviors, and digit ratios (2D:4D). Archives of Sexual Behavior 2009, 38:442-455.
6. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study. Journal of Clinical Endocrinology and Metabolism 2002, 87:589-598.
7. Ferrando A.A., Lane H.W., Stuart C.A., Davis-Street J., Wolfe R.R. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. American Journal of Physiology 1996, 270:E627-E633.
8. Fielding R.A., Vellas B., Evans W.J., Bhasin S., Morley J.E., Newman A.B., et al. Sarcopenia: An undiagnosed condition in older adults. Current consensus definition: Prevalence, etiology, and consequences. International Working Group on Sarcopenia. Journal of the American Medical Directors Association 2011, 12:249-256.
9. Fink B., Manning J.T., Neave N. The 2nd-4th digit ratio (2D:4D) and neck circumference: Implications for risk factors in coronary heart disease. International Journal of Obesity (London) 2006, 30:711-714.
10. Fink B., Thanzami V., Seydel H., Manning J.T. Digit ratio and hand-grip strength in German and Mizos men: Cross-cultural evidence for an organizing effect of prenatal testosterone on strength. American Journal of Human Biology 2006, 18:776-782.
11. García-Cruz E., Huguet J., Piqueras M., Ribal M.J., Alcaraz A. Second to fourth digit ratio, adult testosterone level and testosterone deficiency. BJU International 2012, 109:266-271.
12. Hamer M., Molloy G.J. Association of C-reactive protein and muscle strength in the English Longitudinal Study of Ageing. Age (Dordr) 2009, 31:171-177.
13. Janssen I., Heymsfield S.B., Baumgartner R.N., Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. Journal of Applied Physiology 2000, 89:465-471.
14. Jones T.E., Stephenson K.W., King J.G., Knight K.R., Marshall T.L., Scott W.B. Sarcopenia-Mechanisms and treatments. Journal of Geriatric Physical Therapy 2009, 32:83-89.
15. Manning J.T., Bundred P.E. The ratio of 2nd to 4th digit length: A new predictor of disease predisposition?. Medical Hypotheses 2000, 54:855-857.
16. Manning J.T., Wood S., Vang E., Walton J., Bundred P.E., van Heyningen C., et al. Second to fourth digit ratio (2D:4D) and testosterone in men. Asian Journal of Andrology 2004, 6:211-215.
17. Mathiowetz V., Kashman N., Volland G., Weber K., Dowe M., Rogers S. Grip and pinch strength: Normative data for adults. Archives of Physical Medicine and Rehabilitation 1985, 66:69-74.
18. McIntyre M.H., Ellison P.T., Lieberman D.E., Demerath E., Towne B. The development of sex differences in digital formula from infancy in the Fels Longitudinal Study. Proceedings of the Royal Society B 2005, 272:1473-1479.
19. Meng S.J., Yu L.J. Oxidative stress, molecular inflammation and sarcopenia. International Journal of Molecular Sciences 2010, 11:1509-1526.
20. Morishita S., Kaida K., Tanaka T., Itani Y., Ikegame K., Okada M., et al. Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation. Supportive Care in Cancer 2012, 20:3161-3168.
21. Morley J.E., Abbatecola A.M., Argiles J.M., Baracos V., Bauer J., Bhasin S., et al. Sarcopenia with limited mobility: An international consensus. Journal of the American Medical Directors Association 2011, 12:403-409.
22. Morley J.E., Perry H.M. Androgens and women at the menopause and beyond. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2003, 58:M409-M416.
23. Muscaritoli M., Anker S.D., Argilés J., Aversa Z., Bauer J.M., Biolo G., et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) cachexia-anorexia in chronic wasting diseases and nutrition in geriatrics. Clinical Nutrition 2010, 29:154-159.
24. Paddon-Jones D. Interplay of stress and physical inactivity on muscle loss: Nutritional countermeasures. Journal of Nutrition 2006, 136:2123-2126.
25. Rahman A.A., Lophatananon A., Stewart-Brown S., Harriss D., Anderson J., Parker T., et al. Hand pattern indicates prostate cancer risk. British Journal of Cancer 2011, 104:175-177.
26. Rolland Y., Lauwers-Cances V., Cournot M., Nourhashémi F., Reynish W., Rivière D., et al. Sarcopenia, calf circumference, and physical function of elderly women: A cross-sectional study. Journal of the American Geriatrics Society 2003, 51:1120-1124.
27. Sakuma K., Yamaguchi A. Sarcopenia and age-related endocrine function. International Journal of Endocrinology 2012, 2012. 127362.
28. van Anders S.M. Grip strength and digit ratios are not correlated in women. American Journal of Human Biology 2007, 19:437-439.
29. WHO Physical status: The use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organization Technical Report Series 1995, 854:1-452.