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Volumn 131, Issue 2, 2013, Pages 491-501

Fungicide prochloraz and environmental pollutant dioxin induce the ABCG2 transporter in bovine mammary epithelial cells by the arylhydrocarbon receptor signaling pathway

Author keywords

ABCG2 BCRP; Aryl hydrocarbon receptor (AhR); Dioxin; Mammary epithelial cells; Prochloraz; Regulation

Indexed keywords

1,2,3,4,6,7,12,12A OCTAHYDRO 6 ISOBUTYL 9 METHOXY 1,4 DIOXOPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 3 PROPANOIC ACID TERT BUTYL ESTER; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 1A1; HOE 33342; PROCHLORAZ; SALICYLAMIDE;

EID: 84872496705     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs304     Document Type: Article
Times cited : (27)

References (37)
  • 1
    • 0000890967 scopus 로고    scopus 로고
    • Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C
    • Allen, J. D., van Loevezijn, A., Lakhai, J. M., van der Valk, M., van Tellingen, O., Reid, G., Schellens, J. H., Koomen, G. J., and Schinkel, A. H. (2002). Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol. Cancer Ther. 1, 417-425.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 417-425
    • Allen, J.D.1    van Loevezijn, A.2    Lakhai, J.M.3    van der Valk, M.4    van Tellingen, O.5    Reid, G.6    Schellens, J.H.7    Koomen, G.J.8    Schinkel, A.H.9
  • 2
    • 0035929437 scopus 로고    scopus 로고
    • Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene
    • Bailey-Dell, K. J., Hassel, B., Doyle, L. A., and Ross, D. D. (2001). Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim. Biophys. Acta 1520, 234-241.
    • (2001) Biochim. Biophys. Acta , vol.1520 , pp. 234-241
    • Bailey-Dell, K.J.1    Hassel, B.2    Doyle, L.A.3    Ross, D.D.4
  • 3
    • 78649900609 scopus 로고    scopus 로고
    • Exposure of several Belgian consumer groups to pesticide residues through fresh fruit and vegetable consumption
    • Claeys, W. L., Schmit, J. F., Bragard, C., Maghuin-Rogister, G., Pussemier, L., and Schiffers, B. (2011). Exposure of several Belgian consumer groups to pesticide residues through fresh fruit and vegetable consumption. Food control 22, 508-516.
    • (2011) Food control , vol.22 , pp. 508-516
    • Claeys, W.L.1    Schmit, J.F.2    Bragard, C.3    Maghuin-Rogister, G.4    Pussemier, L.5    Schiffers, B.6
  • 5
    • 27144483358 scopus 로고    scopus 로고
    • Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    • Ebert, B., Seidel, A., and Lampen, A. (2005). Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis 26, 1754-1763.
    • (2005) Carcinogenesis , vol.26 , pp. 1754-1763
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 6
    • 33947233105 scopus 로고    scopus 로고
    • Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate
    • Ebert, B., Seidel, A., and Lampen, A. (2007). Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol. Sci. 96, 227-236.
    • (2007) Toxicol. Sci. , vol.96 , pp. 227-236
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 7
    • 85078385290 scopus 로고    scopus 로고
    • Conclusion on the peer review of the pesticide risk assessment of the active substance prochloraz
    • European Food Safety Authority (EFSA). [120 pp.] doi:10.2903/j.efsa.2011.2323.Available at
    • European Food Safety Authority (EFSA). (2011). Conclusion on the peer review of the pesticide risk assessment of the active substance prochloraz. EFSA J 9, 2323. [120 pp.]. doi:10.2903/j.efsa.2011.2323. Available at: www. efsa.europa.eu/efsajournal.htm.
    • (2011) EFSA J , vol.9 , pp. 2323
  • 8
    • 38549153970 scopus 로고    scopus 로고
    • Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: Role of DNA binding and competition for AHR nuclear translocator
    • Evans, B. R., Karchner, S. I., Allan, L. L., Pollenz, R. S., Tanguay, R. L., Jenny, M. J., Sherr, D. H., and Hahn, M. E. (2008). Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: Role of DNA binding and competition for AHR nuclear translocator. Mol. Pharmacol. 73, 387-398.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 387-398
    • Evans, B.R.1    Karchner, S.I.2    Allan, L.L.3    Pollenz, R.S.4    Tanguay, R.L.5    Jenny, M.J.6    Sherr, D.H.7    Hahn, M.E.8
  • 9
    • 77953713215 scopus 로고    scopus 로고
    • Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway
    • Halwachs, S., Lakoma, C., Gebhardt, R., Schäfer, I., Seibel, P., and Honscha, W. (2010). Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway. Toxicol. Appl. Pharmacol. 246, 100-106.
    • (2010) Toxicol. Appl. Pharmacol. , vol.246 , pp. 100-106
    • Halwachs, S.1    Lakoma, C.2    Gebhardt, R.3    Schäfer, I.4    Seibel, P.5    Honscha, W.6
  • 11
    • 0021673552 scopus 로고
    • Effects of sterol biosynthesis-inhibiting (SBI) fungicides on cytochrome P-450 oxygenations in fungi
    • Henry, M. J., and Sisler, H. D. (1984). Effects of sterol biosynthesis-inhibiting (SBI) fungicides on cytochrome P-450 oxygenations in fungi. Pesticide Biochem. Physiol. 22, 262-275.
    • (1984) Pesticide Biochem. Physiol. , vol.22 , pp. 262-275
    • Henry, M.J.1    Sisler, H.D.2
  • 13
    • 33750297793 scopus 로고    scopus 로고
    • Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental models
    • Knerr, S., and Schrenk, D. (2006). Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental models. Mol. Nutr. Food Res. 50, 897-907.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 897-907
    • Knerr, S.1    Schrenk, D.2
  • 14
    • 71349087688 scopus 로고    scopus 로고
    • Responsiveness of a Xenopus laevis cell line to the aryl hydrocarbon receptor ligands 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD)
    • Laub, L. B., Jones, B. D., and Powell, W. H. (2010). Responsiveness of a Xenopus laevis cell line to the aryl hydrocarbon receptor ligands 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD). Chem. Biol. Interact. 183, 202-211.
    • (2010) Chem. Biol. Interact. , vol.183 , pp. 202-211
    • Laub, L.B.1    Jones, B.D.2    Powell, W.H.3
  • 15
    • 0242494051 scopus 로고    scopus 로고
    • Effects of currently used pesticides in the AhR-CALUX assay: Comparison between the human TV101L and the rat H4IIE cell line
    • Long, M., Laier, P., Vinggaard, A. M., Andersen, H. R., Lynggaard, J., and Bonefeld-Jørgensen, E. C. (2003). Effects of currently used pesticides in the AhR-CALUX assay: Comparison between the human TV101L and the rat H4IIE cell line. Toxicology 194, 77-93.
    • (2003) Toxicology , vol.194 , pp. 77-93
    • Long, M.1    Laier, P.2    Vinggaard, A.M.3    Andersen, H.R.4    Lynggaard, J.5    Bonefeld-Jørgensen, E.C.6
  • 16
    • 1642535537 scopus 로고    scopus 로고
    • The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • MacDonald, C. J., Ciolino, H. P., and Yeh, G. C. (2004). The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Res. 64, 429-434.
    • (2004) Cancer Res , vol.64 , pp. 429-434
    • MacDonald, C.J.1    Ciolino, H.P.2    Yeh, G.C.3
  • 18
    • 0031860431 scopus 로고    scopus 로고
    • An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis
    • McGregor, D. B., Partensky, C., Wilbourn, J., and Rice, J. M. (1998). An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis. Environ. Health Perspect. 106(SUPPL. 2), 755-760.
    • (1998) Environ. Health Perspect , vol.106 , Issue.SUPPL. 2 , pp. 755-760
    • McGregor, D.B.1    Partensky, C.2    Wilbourn, J.3    Rice, J.M.4
  • 19
    • 33645108568 scopus 로고    scopus 로고
    • Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion
    • Merino, G., Alvarez, A. I., Pulido, M. M., Molina, A. J., Schinkel, A. H., and Prieto, J. G. (2006). Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metab. Dispos. 34, 690-695.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 690-695
    • Merino, G.1    Alvarez, A.I.2    Pulido, M.M.3    Molina, A.J.4    Schinkel, A.H.5    Prieto, J.G.6
  • 20
    • 71549117271 scopus 로고    scopus 로고
    • Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism
    • Moyes, K. M., Drackley, J. K., Morin, D. E., Bionaz, M., Rodriguez-Zas, S. L., Everts, R. E., Lewin, H. A., and Loor, J. J. (2009). Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism. BMC Genomics 10, 542.
    • (2009) BMC Genomics , vol.10 , pp. 542
    • Moyes, K.M.1    Drackley, J.K.2    Morin, D.E.3    Bionaz, M.4    Rodriguez-Zas, S.L.5    Everts, R.E.6    Lewin, H.A.7    Loor, J.J.8
  • 21
    • 0028223766 scopus 로고
    • Active transport of benzo[a]pyrene in apical membrane vesicles from normal human intestinal epithelium
    • Penny, J. I., and Campbell, F. C. (1994). Active transport of benzo[a]pyrene in apical membrane vesicles from normal human intestinal epithelium. Biochim. Biophys. Acta 1226, 232-236.
    • (1994) Biochim. Biophys. Acta , vol.1226 , pp. 232-236
    • Penny, J.I.1    Campbell, F.C.2
  • 22
    • 59149097969 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways
    • Puga, A., Ma, C., and Marlowe, J. L. (2009). The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem. Pharmacol. 77, 713-722.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 713-722
    • Puga, A.1    Ma, C.2    Marlowe, J.L.3
  • 23
    • 0036195976 scopus 로고    scopus 로고
    • Microplate screening of the differential effects of test agents on Hoechst 33342, rhodamine 123, and rhodamine 6G accumulation in breast cancer cells that overexpress P-glycoprotein
    • Sarver, J. G., Klis, W. A., Byers, J. P., and Erhardt, P. W. (2002). Microplate screening of the differential effects of test agents on Hoechst 33342, rhodamine 123, and rhodamine 6G accumulation in breast cancer cells that overexpress P-glycoprotein. J. Biomol. Screen. 7, 29-34.
    • (2002) J. Biomol. Screen. , vol.7 , pp. 29-34
    • Sarver, J.G.1    Klis, W.A.2    Byers, J.P.3    Erhardt, P.W.4
  • 24
    • 0035754782 scopus 로고    scopus 로고
    • Neurotransmitter-stimulated ion transport across cultured bovine mammary epithelial cell monolayers
    • Schmidt, C. R., Carlin, R. W., Sargeant, J. M., and Schultz, B. D. (2001). Neurotransmitter-stimulated ion transport across cultured bovine mammary epithelial cell monolayers. J. Dairy Sci. 84, 2622-2631.
    • (2001) J. Dairy Sci. , vol.84 , pp. 2622-2631
    • Schmidt, C.R.1    Carlin, R.W.2    Sargeant, J.M.3    Schultz, B.D.4
  • 25
    • 0032522907 scopus 로고    scopus 로고
    • Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of endo- and xenobiotics
    • Schrenk, D. (1998). Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of endo- and xenobiotics. Biochem. Pharmacol. 55, 1155-1162.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1155-1162
    • Schrenk, D.1
  • 26
    • 38649129374 scopus 로고    scopus 로고
    • Levels and congener distributions of PCDDs PCDFs and dioxin-like PCBs in environmental and human samples: A review
    • Scrogi, K. (2008). Levels and congener distributions of PCDDs, PCDFs and dioxin-like PCBs in environmental and human samples: A review. Environ. Chem. Lett. 6, 1-28.
    • (2008) Environ. Chem. Lett. , vol.6 , pp. 1-28
    • Scrogi, K.1
  • 28
    • 84873860422 scopus 로고    scopus 로고
    • Expression and inducibility of AhR-responsive genes in a Bovine Mammary Epithelial cell line (BME-UV)
    • (Abstract)
    • Spalenza, V., Girolami, F., Manzini, L., and Nebbia, C. (2012). Expression and inducibility of AhR-responsive genes in a Bovine Mammary Epithelial cell line (BME-UV). J. Vet. Pharmacol. Therap. 35(SUPPL.), 34-35 (Abstract).
    • (2012) J. Vet. Pharmacol. Therap. , vol.35 , Issue.SUPPL. , pp. 34-35
    • Spalenza, V.1    Girolami, F.2    Manzini, L.3    Nebbia, C.4
  • 29
    • 0035427599 scopus 로고    scopus 로고
    • Effects of prochloraz and nonylphenol diethoxylate on hepatic biotransformation enzymes in trout: A comparative in vitro/in vivo-assessment using cultured hepatocytes
    • Sturm, A., Cravedi, J. P., Perdu, E., Baradat, M., and Segner, H. (2001). Effects of prochloraz and nonylphenol diethoxylate on hepatic biotransformation enzymes in trout: A comparative in vitro/in vivo-assessment using cultured hepatocytes. Aquat. Toxicol. 53, 229-245.
    • (2001) Aquat. Toxicol. , vol.53 , pp. 229-245
    • Sturm, A.1    Cravedi, J.P.2    Perdu, E.3    Baradat, M.4    Segner, H.5
  • 31
    • 77957905037 scopus 로고    scopus 로고
    • A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells
    • Tompkins, L. M., Li, H., Li, L., Lynch, C., Xie, Y., Nakanishi, T., Ross, D. D., and Wang, H. (2010). A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells. Biochem. Pharmacol. 80, 1754-1761.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1754-1761
    • Tompkins, L.M.1    Li, H.2    Li, L.3    Lynch, C.4    Xie, Y.5    Nakanishi, T.6    Ross, D.D.7    Wang, H.8
  • 32
    • 29744441900 scopus 로고    scopus 로고
    • Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1 IQ and Trp-P-1 but also mediates their secretion into breast milk
    • van Herwaarden, A. E., Wagenaar, E., Karnekamp, B., Merino, G., Jonker, J. W., and Schinkel, A. H. (2006). Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk. Carcinogenesis 27, 123-130.
    • (2006) Carcinogenesis , vol.27 , pp. 123-130
    • van Herwaarden, A.E.1    Wagenaar, E.2    Karnekamp, B.3    Merino, G.4    Jonker, J.W.5    Schinkel, A.H.6
  • 35
    • 22044449137 scopus 로고    scopus 로고
    • Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions
    • Vrzal, R., Ulrichová J., and Dvorák, Z. (2004). Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions. Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub. 148, 3-10.
    • (2004) Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub. , vol.148 , pp. 3-10
    • Vrzal, R.1    Ulrichová, J.2    Dvorák, Z.3
  • 36
    • 0026490937 scopus 로고
    • A new functional role for P-glycoprotein: Efflux pump for benzo(alpha)pyrene in human breast cancer MCF-7 cells
    • Yeh, G. C., Lopaczynska, J., Poore, C. M., and Phang, J. M. (1992). A new functional role for P-glycoprotein: Efflux pump for benzo(alpha)pyrene in human breast cancer MCF-7 cells. Cancer Res. 52, 6692-6695.
    • (1992) Cancer Res , vol.52 , pp. 6692-6695
    • Yeh, G.C.1    Lopaczynska, J.2    Poore, C.M.3    Phang, J.M.4
  • 37
    • 0029963027 scopus 로고    scopus 로고
    • Establishment and characterization of a bovine mammary epithelial cell line with unique properties
    • Zavizion, B., van Duffelen, M., Schaeffer, W., and Politis, I. (1996). Establishment and characterization of a bovine mammary epithelial cell line with unique properties. In Vitro Cell. Dev. Biol. Anim. 32, 138-148.
    • (1996) In Vitro Cell. Dev. Biol. Anim. , vol.32 , pp. 138-148
    • Zavizion, B.1    van Duffelen, M.2    Schaeffer, W.3    Politis, I.4


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