Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera

Journal of Pharmaceutical Sciences

Volumn 102, Issue 2, 2013, Pages 480-488

  Chopra, Poonam ^a   Hao, Jinsong ^a   Li, S Kevin ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Corticosteroids, ophthalmic drug delivery; Human sclera; Iontophoresis; Lipophilic drugs; Micelles; Nanoparticles; Sustained release

Indexed keywords

DEXAMETHASONE; ESTRADIOL; PHOSPHATIDYLCHOLINE; TAUROCHOLIC ACID; TRIAMCINOLONE ACETONIDE;

ACTIVE TRANSPORT; ARTICLE; CHEMICAL MODEL; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG LIPOPHILICITY; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; ENCAPSULATION; HUMAN; HUMAN TISSUE; HYDRODYNAMICS; IN VITRO STUDY; IONTOPHORESIS; LIPOPHILICITY; MICELLE; MIXED MICELLAR CARRIER SYSTEM; PASSIVE TRANSPORT; PHYSICAL CHEMISTRY; SCLERA; ZETA POTENTIAL;

EID: 84872485933     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23370     Document Type: Article

References (24)

1. Worakul N, Robinson JR. 1997. Ocular pharmacokinetics/pharmacodynamics. Euro J Pharm Biopharm 44(1):71-83.
2. Maurice DM. 2002. Drug delivery to the posterior segment from drops. Surv Ophthalmol 47:S41-S52.
3. Geroski DH, Edelhauser HF. 2000. Drug delivery for posterior segment eye disease. Invest Ophthalmol Vis Sci 41(5):961-964.
4. Lee SS, Hughes PM, Robinson MR. 2009. Recent advances in drug delivery systems for treating ocular complications of systemic diseases. Curr Opin Ophthalmol 20(6):511-519.
5. Meyer CH, Krohne TU, Holz FG. 2011. Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans. Retina 31(9):1877-1884.
6. Jager RD, Aiello LP, Patel SC, Cunningham ET. 2004. Risks of intravitreous injection: A comprehensive review. Retina 24(5):676-698.
7. Sampat KM, Garg SJ. 2010. Complications of intravitreal injections. Curr Opin Ophthalmol 21(3):178-183.
8. Behrens-Baumann W, Martell J. 1988. Ciprofloxacin concentration in the rabbit aqueous humor and vitreous following intravenous and subconjunctival administration. Infection 16(1):54-57.
9. Clements DB, Tailor V. 1987. A study of aqueous and serum levels of ceftazidime following subconjunctival administration. Br J Ophthalmol 71(6):433-435.
10. Raghava S, Hammond M, Kompella UB. 2004. Periocular routes for retinal drug delivery. Expert Opin Drug Deliv 1(1):99-114.
11. Olsen TW, Aaberg SY, Geroski DH, Edelhauser HF. 1998. Human sclera: Thickness and surface area. Am J Ophthalmol 125(2):237-241.
12. Watsky MA, Jablonski MM, Edelhauser HF. 1988. Comparison of conjunctival and corneal surface areas in rabbit and human. Curr Eye Res 7(5):483-486.
13. Eljarrat-Binstock E, Domb AJ. 2006. Iontophoresis: A non-invasive ocular drug delivery. J Control Release 110(3):479-489.
14. Nicoli S, Ferrari G, Quarta M, Macaluso C, Santi P. 2009. In vitro transscleral iontophoresis of high molecular weight neutral compounds. Eur J Pharm Sci 36(4-5):486-492.
15. Chopra P, Hao J, Li SK. 2012. Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera. J Control Release 160(1):96-104.
16. Alkan-Onyuksel H, Son K. 1992. Mixed micelles as proliposomes for the solubilization of teniposide. Pharm Res 9(12):1556-1562.
17. Parkinson TM, Ferguson E, Febbraro S, Bakhtyari A, King M, Mundasad M. 2003. Tolerance of ocular iontophoresis in healthy volunteers. J Ocul Pharmacol Ther 19(2):145-151.
18. Chopra P, Hao J, Li SK. 2010. Iontophoretic transport of charged macromolecules across human sclera. Int J Pharm 388(1-2):107-113.
19. Saraiya NV, Goldstein DA. 2011. Dexamethasone for ocular inflammation. Expert Opin Pharmacother 12(7):1127-1131.
20. Barry A, Rousseau A, Babineau LM. 1969. The penetration of steroids into the rabbit's vitreous, choroid and retina following retrobulbar injection. Can J Ophthalmol 4(4):365-369.
21. Boscia F, Furino C, Dammacco R, Ferreri P, Sborgia L, Sborgia C. 2005. Intravitreal triamcinolone acetonide in refractory pseudophakic cystoid macular edema: Functional and anatomic results. Eur J Ophthalmol 15(1):89-95.
22. Cekic O, Chang S, Tseng JJ, Barile GR, Weissman H, Del Priore LV, Schiff WM, Weiss M, Klancnik JM Jr. 2005. Intravitreal triamcinolone treatment for macular edema associated with central retinal vein occlusion and hemiretinal vein occlusion. Retina 25(7):846-850.
23. Alkan-Onyuksel H, Ramakrishnan S, Chai HB, Pezzuto JM. 1994. A mixed micellar formulation suitable for the parenteral administration of taxol. Pharm Res 11(2):206-212.
24. Hammad MA, Muller BW. 1999. Solubility and stability of lorazepam in bile salt/soya phosphatidylcholine-mixed micelles. Drug Dev Ind Pharm 25(4):409-417.