Paleo-Balkan and Slavic Contributions to the Genetic Pool of Moldavians: Insights from the Y Chromosome

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Varzari, Alexander ^a,b,c   Kharkov, Vladimir ^b   Nikitin, Alexey G ^d   Raicu, Florina ^e,f   Simonova, Kseniya ^b   Stephan, Wolfgang ^c   Weiss, Elisabeth H ^c   Stepanov, Vadim ^b,g  

^a Phthisiopneumology Institute Chiril Draganiuc   (Moldova)

^b RESEARCH INSTITUTE OF MEDICAL GENETICS   (Russian Federation)

^c UNIVERSITY OF MUNICH   (Germany)

^d GRAND VALLEY STATE UNIVERSITY   (United States)

^e ACADEMY OF ROMANIAN SCIENTISTS   (Romania)

^f CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^g Genomnaya Diagnostika Ltd   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BALKAN PENINSULA; GENE POOL; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; MALE; MOLDOVA; PHYLOGENY; ROMANIA; SHORT TANDEM REPEAT; UKRAINE; Y CHROMOSOME;

BALKAN PENINSULA; CHROMOSOMES, HUMAN, Y; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATHERS; GENE POOL; GENETIC VARIATION; HAPLOTYPES; HUMANS; MALE; MICROSATELLITE REPEATS; MOLDOVA;

EID: 84872484272     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053731     Document Type: Article

References (51)

1. Renfrew AC (1987) Archaeology and Language: The Puzzle of Indo-European Origins. London: Jonathan Cape. 368 p.
2. Larina O (2010) Inceputurile economiei productive. Neoliticul. Oranduirea gentilico-tribala. In: Dergaciov V, editor. Istoria Moldovei: Epoca preistorica si antica (pina in sec. V). Chisinau, Moldova: Academia de Stiinte a Moldovei. 177-218.
3. Zbenovich VG, (1996) The Tripolye Culture: Centenary of Research. Journal of World Prehistory 10: 199-241.
4. Gimbutas M, (1973) The beginning of the Bronze Age in Europe and the Indo-Europeans: 3500-2500 B.C. Journal of Indo-European Studies. 1: 163-214.
5. Dergachev VA, (2000) The Migration Theory of Marija Gimbutas. Journal of Indo-European Studies 28: 257-339.
6. Dumitrescu VL, Bolomey A, Mogoşanu F (1982) The Prehistory of Romania from the earliest times to 1000 B.C. In: Boardman J, Edwards IES, Hammond NGL and Sollberger E, editors. The Prehistory of the Balkans; and the Middle East and the Aegean world, tenth to eighth centuries B.C. Cambridge: Cambridge University Press. 1-74.
7. Garašanin M (1982) The Bronze Age in the Central Balkan Area. In: Boardman J, Edwards IES, Hammond NGL, Sollberger E, editors. The Prehistory of the Balkans; and the Middle East and the Aegean world, tenth to eighth centuries B.C. Cambridge, UK: Cambridge University Press. 75-186.
8. Klepper N (2002) Romania: an illustrated history. New York: Hippocrene Books. 298 p.
9. Kasuba M, Levitki O, Agulnicov S (2010) Prima epoca a fierului (sec. XII-VIII/VII i. Hr.). Inceputurile relatiilor de clasa. In: Dergaciov V, editor. Istoria Moldovei: Epoca preistorica si antica(pina in sec. V). Chisinau: Academia de Stiinte a Moldovei. 313-413.
10. Fyodorov GB, (1999) Ethno-genesis of the Vlachs, Moldovan's ancestors, according to the archaeological data (historiographical aspect). Stratum Plus 5: 14-74.
11. Shchukin MB (1989) Rome and the barbarians in central and eastern Europe: 1st century B.C.-1st century A.D. Oxford, UK: B.A.R. 542 p.
12. Sedov VV (2002) The Slavs. Historical and archaeological study. Moscow: Iazyki slavianskoi kul'tury. 622 p.
13. Russev ND, (1999) Moldavia in "Dark Ages". Materials for understanding cultural and historical processes. Stratum Plus 5: 379-407.
14. Guboglo MN, Dergachev VA (2010) The Moldavians. Moscow: Nauka. 541 p.
15. Varsahr AM, Scheil HG, Schmidt HD, (2006) Blood group and serum protein polymorphisms in a population group of Moldavians. Anthropol Anz 64: 51-58.
16. Varzari A, Stephan W, Stepanov V, Raicu F, Cojocaru R, et al. (2007) Population history of the Dniester-Carpathians: evidence from Alu markers. J Hum Genet 52: 308-316.
17. Jobling MA, Tyler-Smith C, (2003) The human Y chromosome: an evolutionary marker comes of age. Nat Rev Genet 4: 598-612.
18. Stefan M, Stefanescu G, Gavrila L, Terrenato L, Jobling MA, et al. (2001) Y chromosome analysis reveals a sharp genetic boundary in the Carpathian region. Eur J Hum Genet 9: 27-33.
19. Rootsi S, Magri C, Kivisild T, Benuzzi G, Help H, et al. (2004) Phylogeography of Y-chromosome haplogroup I reveals distinct domains of prehistoric gene flow in Europe. Am J Hum Genet 75: 128-137.
20. Cruciani F, La Fratta R, Trombetta B, Santolamazza P, Sellitto D, et al. (2007) Tracing past human male movements in northern/eastern Africa and western Eurasia: new clues from Y-chromosomal haplogroups E-M78 and J-M12. Mol Biol Evol 24: 1300-1311.
21. Nasidze I, Quinque D, Udina I, Kunizheva S, Stoneking M, (2007) The Gagauz, a linguistic enclave, are not a genetic isolate. Ann Hum Genet 71: 379-389.
22. Miller SA, Dykes DD, Polesky HF, (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215.
23. Hammer MF, Horai S, (1995) Y chromosomal DNA variation and the peopling of Japan. Am J Hum Genet 56: 951-962.
24. Rosser ZH, Zerjal T, Hurles ME, Adojaan M, Alavantic D, et al. (2000) Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. Am J Hum Genet 67: 1526-1543.
25. Kharkov VN, Stepanov VA, Borinskaia SA, Kozhekbaeva ZhM, Gusar VA, et al. (2004) Gene pool structure of Eastern Ukrainians as inferred from the Y-chromosomal haplogroups. Russ J Genet 40: 326-331.
26. Mathias N, Bayes M, Tyler-Smith C, (1994) Highly informative compound haplotypes for the human Y chromosome. Hum Mol Genet 3: 115-123.
27. Zerjal T, Dashnyam B, Pandya A, Kayser M, Roewer L, et al. (1997) Genetic relationship of Asians and Northern Europeans, revealed by Y chromosomal DNA analysis. Am J Hum Genet 60: 1174-1183.
28. Hurles ME, Irven C, Nicholson J, Taylor PG, Santos FR, et al. (1998) European Y chromosomal lineages in Polynesia: a contrast to the population structure revealed by mitochondrial DNA. Am J Hum Genet 63: 1793-1806.
29. Kharkov VN, Stepanov VA, Medvedeva OF, Spiridonova MG, Voevoda MI, et al. (2007) Gene pool differences between northern and southern Altaians inferred from the data on Y-chromosomal haplogroups. Russ J Genet 43: 675-687.
30. Flores C, Maca-Meyer N, Perez JA, Gonzalez AM, Larruga JM, et al. (2003) A predominant European ancestry of paternal lineages from Canary Islanders. Ann Hum Genet 67: 138-152.
31. Kharkov NV, Stepanov VA, Puzyrev VP, Feschenko SP, Borinskaya SA, et al. (2005) Frequency of Y chromosomal bi-allelic haplogroups in Belorussians. Russ J Genet 41: 938-931.
32. Hurles ME, Veitia R, Arroyo E, Armenteros M, Bertranpetit J, et al. (1999) Recent male-mediated gene flow over a linguistic barrier in Iberia, suggested by analysis of a Y-chromosomal DNA polymorphism. Am J Hum Genet 67: 1055-1061.
33. Varzari A, Kharkov V, Stephan W, Dergachev V, Puzyrev V, et al. (2009) Searching for the origin of Gagauzes: inferences from Y-chromosome analysis. Am J Hum Biol 21: 326-336.
34. Karafet TM, Osipova LP, Gubina MA, Posukh OL, Zegura SL, et al. (2002) High levels of Y-chromosome differentiation among native Siberian populations and the genetic signature of a boreal hunter-gatherer way of life. Hum Biol 74: 761-789.
35. Kharkov VN, Khamina KV, Medvedeva OF, Shtygasheva OV, Stepanov VA, (2011) Genetic diversity of Khakassian gene pool: subethnic differentiation and the structure of Y-chromosome haplogroups. Mol Biol (Mosk) 45: 446-458.
36. Myres NM, Ekins JE, Lin AA, Cavalli-Sforza LL, Woodward SR, et al. (2007) Y-chromosome short tandem repeat DYS458.2 non-consensus alleles occur independently in both binary haplogroups J1-M267 and R1b3-M405. Croat Med J 48: 450-9.
37. Myres NM, Rootsi S, Lin AA, Jarve M, King RJ, et al. (2011) A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe. Eur J Hum Genet 19: 95-101.
38. Y Chromosome Consortium, (2002) A nomenclature system for the tree of human Y-chromosomal binary haplogroups. Genome Res 12: 339-348.
39. Cruciani F, La Fratta R, Torroni A, Underhill PA, Scozzari R, (2006) Molecular dissection of the Y chromosome haplogroup E-M78 (E3b1a): a posteriori evaluation of a microsatellite-network-based approach through six new biallelic markers. Hum Mutat 27: 831-832.
40. Sims LM, Garvey D, Ballantyne J, (2009) Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs. PLoS One 4: e5792.
41. Battaglia V, Fornarino S, Al-Zahery N, Olivieri A, Pala M, et al. (2009) Y-chromosomal evidence of the cultural diffusion of agriculture in Southeast Europe. Eur J Hum Genet 17: 820-830.
42. de Knijff P, Kayser M, Caglià A, Corach D, Fretwell N, et al. (1997) Chromosome Y microsatellites: population genetic and evolutionary aspects. Int J Legal Med 110: 134-149.
43. Kayser M, Caglià A, Corach D, Fretwell N, Gehrig C, et al. (1997) Evaluation of Y-chromosomal STRs: a multicenter study. Int J Legal Med 110: 125-133.
44. Butler JM, Schoske R, Vallone PM, Kline MC, Redd AJ, et al. (2002) A novel multiplex for simultaneous amplification of 20 Y chromosome STR markers. Forensic Sci Int 129: 10-24.
45. Ayub Q, Mohyuddin A, Qamar R, Mazhar K, Zerjal T, et al. (2000) Identification and characterisation of novel human Y-chromosomal microsatellites from sequence database information. Nucleic Acids Res 28: e8.
46. Excoffier L, Lischer HE, (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Resour 10: 564-567.
47. Bandelt HJ, Forster P, Rohl A, (1999) Median-joining networks for inferring intraspecific phylogenies. Mol Biol Evol 16: 37-48.
48. Bosch E, Calafell F, Gonzalez-Neira A, Flaiz C, Mateu E, et al. (2006) Paternal and maternal lineages in the Balkans show a homogeneous landscape over linguistic barriers, except for the isolated Aromuns. Ann Hum Genet 70: 459-487.
49. Underhill PA, Myres NM, Rootsi S, Metspalu M, Zhivotovsky LA, et al. (2010) Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a. Eur J Hum Genet 18: 479-484.
50. Balanovsky O, Rootsi S, Pshenichnov A, Kivisild T, Churnosov M, et al. (2008) Two sources of the Russian patrilineal heritage in their Eurasian context. Am J Hum Genet 82: 236-250.
51. Csányi B, Bogácsi-Szabó E, Tömöry G, Czibula A, Priskin K, et al. (2008) Y-chromosome analysis of ancient Hungarian and two modern Hungarian-speaking populations from the Carpathian Basin. Ann Hum Genet 72: 519-534.