Effects of metronidazole analogues on Giardia lamblia: Experimental infection and cell organization

Diagnostic Microbiology and Infectious Disease

Volumn 75, Issue 2, 2013, Pages 160-164

  Busatti, Haendel G N O ^a,b   Alves, Ricardo J ^a   Santana Anjos, Karla G ^c   Gil, Frederico F ^a   Cury, Marcia C ^d   Vannier Santos, Marcos A ^c   Gomes, Maria A ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSIDADE DE ITAÚNA   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

Author keywords

Electron microscopy; Giardicidal activity; Metronidazole analogues; Parasite load

Indexed keywords

ANTIPARASITIC AGENT; METRONIDAZOLE; METRONIDAZOLE BROMINE; METRONIDAZOLE IODINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; AUTOPHAGY; CELL DIFFERENTIATION; CELL MIGRATION; CELL VACUOLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; DRUG POTENCY; EXPERIMENTAL INFECTION; FEMALE; GERBIL; GIARDIA LAMBLIA; GIARDIASIS; IC 50; MALE; MOLECULAR DYNAMICS; NONHUMAN; PARASITE IDENTIFICATION; PARASITE LOAD; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; GERBILLINAE; GIARDIA LAMBLIA; GIARDIASIS; INHIBITORY CONCENTRATION 50; METRONIDAZOLE; MICROSCOPY, ELECTRON, TRANSMISSION; PARASITE LOAD; TROPHOZOITES;

EID: 84872468605     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2012.11.001     Document Type: Article

References (35)

1. Abodeely M., DuBois K.N., Hehl A., Stefanic S., Sajid M., et al. A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryot Cell 2009, 8:1665-1676.
2. Ankarklev J., Jerlström-Hultqvist J., Ringqvist E., Troell K., Svärd S.G. Behind the smile: cell biology and disease mechanisms of Giardia species. Nat Rev Microbiol 2010, 8:413-422.
3. Araújo N.S., Mundim M.J., Gomes M.A., Amorim R.M., Viana J.C., et al. Giardia duodenalis: pathological alterations in gerbils, Meriones unguiculatus, infected with different dosages of trophozoites. Exp Parasitol 2008, 118:449-457.
4. Argüello-García R., Cruz-Soto M., Romero-Montoya L., Ortega-Pierres G. In vitro resistance to 5-nitroimidazoles and benzimidazoles in Giardia duodenalis: variability and variation in gene expression. Infect Genet Evol 2009, 9:1057-1064.
5. Bansal D., Sehgal R., Chawla Y., Malla N., Mahajan R.C. Multidrug resistance in amoebiasis patients. Indian J Med Res 2006, 124:189-194.
6. Barbosa E., Calzada F., Campos R. Antigiardial activity of methanolic extracts from Helianthemum glomeratum Lag. and Rubus coriifolius Focke in suckling mice CD-1. J Ethnopharmacol 2006, 108:395-397.
7. Belosevic M., Faubert G.M., Maclean J.D., Law C. Giardia lamblia infections in Mongolian gerbils: an animal model. J Infect Dis 1983, 147:222-226.
8. Bernardes C.F., Meyer-Fernandes J.R., Saad-Nehme J., Vannier-Santos M.A., Peres-Sampaio C.E., et al. Effects of 4,4'-diisothyocyanatostilbene-2,2'-disulfonic acid on Trypanosoma cruzi proliferation and Ca(2+) homeostasis. Int J Biochem Cell Biol 2000, 32:519-527.
9. Buret A.G. Pathophysiology of enteric infections with Giardia duodenalis. Parasite 2008, 15:261-265.
10. Buret A.G., Mitchell K., Muench D.G., Scott K.G. Giardia lamblia disrupts tight junctional ZO-1 and increases permeability in non-transformed human small intestinal epithelial monolayers: effects of epidermal growth factor. Parasitol 2002, 125:11-19.
11. Busatti H.G.N.O., Santos J.F.G., Gomes M.A. The old and new therapeutic approaches to the treatment of giardiasis: Where are we?. Biologics: Targets and Therapy 2009, 3:273-287.
12. Busatti H.G.N.O., Vieira A.E., Viana J.C., Silva H.E., Souza-Fagundes E.M., Martins-Filho O., et al. Effect of metronidazole analogues on Giardia lamblia cultures. Parasitol Res 2007, 102:145-149.
13. Cavalcanti J.C.M., Abreu F.C., Oliveira N.V., Moura M.A.B.F., Chaves J.G., Alves R.J. Effect of the leaving group on the electrodic reduction mechanism of anti-Helicobacter pylori metronidazole derivates, in aprotic and protic media. Bioelectrochem 2004, 63:353-357.
14. Cotton J.A., Beatty J.K., Buret A.G. Host parasite interactions and pathophysiology in Giardia infections. Int J Parasitol 2011, 41:925-933.
15. Edwards D.I. Nitroimidazole drugs - Mechanisms of action and resistance mechanisms. J Antimicrob Chemother 1993, 31:9-20.
16. English L., Chemali M., Duron J., Rondeau C., Laplante A., Gingras D., et al. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol 2009, 10:480-487.
17. Farthing M.J., Mata L., Urrutia J.J., Kronmal R.A. Natural history of Giardia infection of infants and children in rural Guatemala and its impact on physical growth. Am J Clin Nutr 1986, 43:395-405.
18. Keister D.B. Axenic cultivation of Giardia lamblia in TYI-S-33 medium supplemented with bile. Trans R Soc Trop Med Hyg 1983, 77:487-488.
19. Leitsch D., Burgess A.G., Dunn L.A., Krauer K.G., Tan K., et al. Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia. J Antimicrob Chemother 2011, 66:1756-1765.
20. Maia C., Lanfredi-Rangel A., Santana-Anjos K.G., Oliveira M.F., DeSouza W., et al. Effects of a putrescine analog on Giardia lamblia. Parasitol Res 2008, 103:363-370.
21. Mirza H., Wu Z., Kidwai F., Tan K.S. A metronidazole-resistant isolate of Blastocystis spp. is susceptible to nitric oxide and downregulates intestinal epithelial inducible nitric oxide synthase by a novel parasite survival mechanism. Infect Immun 2011, 79:5019-5026.
22. Müller O., Sattler T., Flötenmeyer M., Schwarz H., Plattner H., et al. Autophagic tubes: vacuolar invaginations involved in lateral membrane sorting and inverse vesicle budding. Cell Biol 2000, 151:519-528.
23. Müller J., Sterk M., Hemphill A., Müller N. Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole. J Antimicrob Chemother 2007, 60:280-287.
24. Olson M.E., Ceri H., Morck D.W. Giardia vaccination. Parasitol Today 2000, 16:213-217.
25. Savioli L., Smith H., Thompson A. Giardia and Cryptosporidium join the 'Neglected Diseases Initiative'. Trends Parasitol 2006, 22:203-208.
26. Simsek Z., Zeyrek F.Y., Kurcer M.A. Effect of Giardia infection on growth and psychomotor development of children aged 0-5 years. J Trop Pediatr 2004, 50:90-93.
27. Tejman-Yarden N., Millman M., Lauwaet T., Davids B.J., Gillin F.D., et al. Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia. Antimicrob Agents Chemother 2011, 55:4643-4651.
28. Thompson R.C.A., Reynoldson J.A., Mendis A.H.W. Giardia and giardiasis. Adv Parasitol 1993, 32:71-160.
29. Upcroft J.A., Dunn L.A., Wright J.M., Benakli K., Upcroft P., et al. 5-Nitroimidazole drugs effective against metronidazole-resistant Trichomonas vaginalis and Giardia duodenalis. Antimicrob Agents Chemother 2006, 50:344-347.
30. Upcroft P., Upcroft J.A. Drug targets and mechanisms of resistance in the anaerobic protozoa. Clin Microbiol Rev 2001, 14:150-164.
31. Vannier-Santos M.A., de Castro S.L. Electron microscopy in antiparasitic chemotherapy: a (close) view to a kill. Curr Drug Targets 2009, 10:246-260.
32. Vannier-Santos M.A., Martiny A., Lins U., Urbina J.A., Borges V.M., et al. Impairment of sterol biosynthesis leads to phosphorus and calcium and calcium accumulation in Leishmania acidocalcisomes. Microbiol 1999, 145:3213-3220.
33. Wensaas K.A., Langeland N., Rortveit G. Post-infectious gastrointestinal symptoms after acute giardiasis. A 1-year follow-up in general practice. Fam Pract 2010, 27:255-259.
34. Wright J.M., Dunn L.A., Upcroft P., Upcroft J.A. Efficacy of antigiardial drugs. Expert Opin Drug Saf 2003, 2:529-541.
35. Yason J.A., Rivera W.L. Genotyping of Giardia duodenalis isolates among residents of slum area in Manila, Philippines. Parasitol Res 2007, 101:681-687.