Neuronal overexpression of nogo receptor 1 in APPswe/PSEN1(ΔE9) mice impairs spatial cognition tasks without influencing plaque formation

Journal of Alzheimer's Disease

Volumn 33, Issue 1, 2013, Pages 145-155

  Karlsson, Tobias E ^a   Karlén, Alexandra ^b   Olson, Lars ^a   Josephson, Anna ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

Amyloid; amyloid beta protein (40 42); maze learning; NOGO receptor; plaque; RTN4r

Indexed keywords

MEMBRANE RECEPTOR; NOGO RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; COGNITION; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 84872451023     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120493     Document Type: Article

References (30)

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M (2005) Global prevalence of dementia: A Delphi consensus study. Lancet 366, 2112-2117. (Pubitemid 41797645)
2. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
3. Selkoe DJ (2005) Defining molecular targets to prevent Alzheimer disease. Arch Neurol 62, 192-195. (Pubitemid 40204739)
4. Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H (2000) BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloidbeta precursor protein. Proc Natl Acad Sci U S A 97, 9712-9717. (Pubitemid 30650841)
5. Deuss M, Reiss K, Hartmann D (2008) Part-time alphasecretases: The functional biology of ADAM 9, 10 and 17. Curr Alzheimer Res 5, 187-201. (Pubitemid 351536344)
6. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434-439. (Pubitemid 30073093)
7. GrandPre T, Nakamura F,Vartanian T, StrittmatterSM(2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439-444. (Pubitemid 30073094)
8. Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G, Michalovich D, Simmons DL, Walsh FS (2000) Inhibitor of neurite outgrowth in humans. Nature 403, 383-384. (Pubitemid 30073077)
9. Schwab ME (2010) Functions of Nogo proteins and their receptors in the nervous system. Nat Rev Neurosci 11, 799-811.
10. He W, Hu X, Shi Q, Zhou X, Lu Y, Fisher C, Yan R (2006) Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins. J Mol Biol 363, 625-634. (Pubitemid 44486217)
11. He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R (2004) Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat Med 10, 959-965. (Pubitemid 39273737)
12. Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W (2006) Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid betaprotein. Eur J Neurosci 24, 1237-1244. (Pubitemid 44401647)
13. Fournier AE, GrandPre T, Strittmatter SM (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341-346. (Pubitemid 32151238)
14. Park JH, Gimbel DA, GrandPre T, Lee JK, Kim JE, Li W, Lee DH, Strittmatter SM (2006) Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci 26, 1386-1395. (Pubitemid 43237009)
15. Park JH, Widi GA, Gimbel DA, Harel NY, Lee DH, Strittmatter SM (2006) Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci 26, 13279-13286. (Pubitemid 46011638)
16. Zhou XD, Hu XY, He WX, Tang XY, Shi Q, Zhang ZH, Yan RQ(2011) Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition. FASEB J 25, 3146-3156.
17. Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB (2003) Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J 22, 3291-3302. (Pubitemid 36834859)
18. Lauren J, Airaksinen MS, Saarma M, Timmusk T (2003) Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Mol Cell Neurosci 24, 581-594. (Pubitemid 37506003)
19. Pignot V, Hein AE, Barske C, Wiessner C, Walmsley AR, Kaupmann K, Mayeur H, Sommer B, Mir AK, Frentzel S (2003) Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem 85, 717-728. (Pubitemid 36531935)
20. Llorens F, Gil V, del Rio JA (2011) Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration. FASEB J 25, 463-475.
21. Pernet V, Schwab ME (2012) The role of Nogo-A in axonal plasticity, regrowth and repair. Cell Tissue Res 349, 97-104.
22. Josephson A, Trifunovski A, Scheele C, Widenfalk J, Wahlestedt C, Brene S, Olson L, Spenger C (2003) Activityinduced and developmental downregulation of the Nogo receptor. Cell Tissue Res 311, 333-342. (Pubitemid 36459672)
23. McGee AW, Yang Y, Fischer QS, Daw NW, Strittmatter SM (2005) Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor. Science 309, 2222-2226. (Pubitemid 41396073)
24. Karlen A, Karlsson TE, Mattsson A, Lundstromer K, Codeluppi S, Pham TM, Backman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, Brene S, Olson L (2009) Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci U S A 106, 20476-20481.
25. ZhuHY, Guo HF, Hou HL, Liu YJ, Sheng SL, Zhou JN (2007) Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease. Hum Pathol 38, 426-434.
26. VanGuilder HD, Farley JA, Yan H, Van Kirk CA, Mitschelen M, Sonntag WE, Freeman WM (2011) Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiol Dis 43, 201-212.
27. Vanguilder HD, Bixler GV, Sonntag WE, Freeman WM (2012) Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. J Neurochem 121, 77-98.
28. Gil V, Nicolas O, Mingorance A, Urena JM, Tang BL, Hirata T, Saez-Valero J, Ferrer I, Soriano E, del Rio JA (2006) Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. J Neuropathol Exp Neurol 65, 433-444. (Pubitemid 44297265)
29. Masliah E, Xie F, Dayan S, Rockenstein E, Mante M, Adame A, Patrick CM, Chan AF, Zheng B (2010) Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice. Neuroscience 169, 488-494.
30. Hashimoto M, Masliah E (2003) Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies. Neurochem Res 28, 1743-1756. (Pubitemid 37296216)