The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding

Journal of Lipid Research

Volumn 54, Issue 2, 2013, Pages 514-521

  Xiao, Xunjun ^a   Ferguson, Michael R ^a   Magee, Kelsey E ^a   Hale, Pamela D ^a   Wang, Yan ^a   Lowe, Mark E ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Enterostatin; Fat digestion; Lag time; Stability

Indexed keywords

ARGININE; COLIPASE; CYSTEINE; INTRALIPID; LONG CHAIN TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; TRIOLEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CELL LYSATE; CELL MIGRATION; CONTROLLED STUDY; DUODENUM MUCOSA; ENDOPLASMIC RETICULUM STRESS; LIPID METABOLISM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MISFOLDING; PROTEIN POLYMORPHISM; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN STRUCTURE; UNFOLDED PROTEIN RESPONSE;

ARGININE; COLIPASES; CYSTEINE; DIABETES MELLITUS, TYPE 2; DIETARY FATS; ENZYME STABILITY; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; TEMPERATURE;

EID: 84872441715     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M034066     Document Type: Article

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