A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides

Journal of Lipid Research

Volumn 48, Issue 11, 2007, Pages 2478-2484

  D'Silva, Sheryl ^a   Xiao, Xunjun ^a   Lowe, Mark E ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Digestion; Lipase; Mutagenesis; Recombinant protein; Type 2 diabetes

Indexed keywords

ARGININE; BILE SALT; COLIPASE; CYSTEINE; DISULFIDE; LONG CHAIN TRIACYLGLYCEROL; MEDIUM CHAIN TRIACYLGLYCEROL; PROCOLIPASE; RECOMBINANT ENZYME; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; COMPARATIVE STUDY; DIABETOGENESIS; EMULSION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION SYSTEM; GENETIC POLYMORPHISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; PANCREAS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; STORAGE TEMPERATURE; YEAST;

AMINO ACID SUBSTITUTION; ARGININE; COLIPASES; CYSTEINE; ENZYME PRECURSORS; ENZYME STABILITY; HUMANS; POLYMORPHISM, GENETIC; TRIGLYCERIDES;

EID: 35848961211     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700371-JLR200     Document Type: Article

References (29)

1. D'Agostino, D., R. A. Cordle, J. Kullman, C. Erlanson-Albertsson, L. J. Muglia, and M. E. Lowe. 2002. Decreased postnatal survival and altered body weight regulation in procolipase deficient mice. J. Biol. Chem. 277: 7170-7177.
2. Borgstrom, B., and C. Erlanson-Albertsson. 1984. Pancreatic colipase. In Lipases. B. Borgstrom and H. L. Brockman, editors. Elsevier, Amsterdam. 152-183.
3. Hildebrand, H., B. Borgstrom, A. Bekassy, C. Erlanson-Albertsson, and A. Helin. 1982. Isolated colipase deficiency in two brothers. Gut. 23: 243-246.
4. Lowe, M. E., J. L. Rosenblum, P. McEwen, and A. W. Strauss. 1990. Cloning and characterization of the human colipase cDNA. Biochemistry. 29: 823-828.
5. Erlanson-Albertsson, C. 1994. Enterostatin - a peptide regulating fat intake. Scand. J. Nutr. 38: 11-14.
6. Berger, K., M. S. Winzell, J. Mei, and C. Erlanson-Albertsson. 2004. Enterostatin and its target mechanisms during regulation of fat intake. Physiol. Behav. 83: 623-630.
7. Lindner, I., U. Helwig, D. Rubin, Y. Li, E. Fisher, H. Boeing, M. Mohlig, J. Spranger, A. Pfeiffer, J. Hampe, et al. 2005. Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations. Mol. Nutr. Food Res. 49: 972-976.
8. Cordle, R., and M. E. Lowe. 1998. The hydrophobic surface of colipase influences lipase activity at an oil-water interface. J. Lipid Res. 39: 1759-1767.
9. van Tilbeurgh, H., S. Bezzine, C. Cambillau, R. Verger, and F. Carriere. 1999. Colipase: structure and interaction with pancreatic lipase. Biochim. Biophys. Acta. 1441: 173-184.
10. rd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
11. Cordle, R. A., and M. E. Lowe. 1998. Purification and characterization of human procolipase expressed in yeast cells. Protein Expr. Purif. 13: 30-35.
12. Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227: 680-685.
13. Yang, Y., and M. E. Lowe. 1998. Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization. Protein Expr. Purif. 13: 36-40.
14. Egloff, M. P., L. Sarda, R. Verger, C. Cambillau, and H. van Tilbeurgh. 1995. Crystallographic study of the structure of colipase and of the interaction with pancreatic lipase. Protein Sci. 4: 44-57.
15. Rugani, N., F. Carriere, L. Thim, B. Borgstrom, and L. Sarda. 1995. Lipid binding and activating properties of porcine pancreatic colipase split at the Ile19-Thr80 bond. Biochim. Biophys. Acta. 1247: 185-194.
16. Chahinian, H., S. Bezzine, F. Ferrato, M. G. Ivanova, B. Perez, M. E. Lowe, and F. Carriere. 2002. The beta 5′ loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. Biochemistry. 41: 13725-13735.
17. Freie, A. B., F. Ferrato, F. Carriere, and M. E. Lowe. 2006. Val-407 and Ile-408 in the beta5′-loop of pancreatic lipase mediate lipasecolipase interactions in the presence of bile salt micelles. J. Biol. Chem. 281: 7793-7800.
18. Hermoso, J., D. Pignol, S. Penel, M. Roth, C. Chapus, and J. C. Fontecilla-Camps. 1997. Neutron crystallographic evidence of lipase-colipase complex activation by a micelle. EMBO J. 16: 5531-5536.
19. Feinle-Bisset, C., M. Patterson, M. A. Ghatei, S. R. Bloom, and M. Horowitz. 2005. Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid. Am. J. Physiol. Endocrinol. Metab. 289: E948-E953.
20. French, S. J., C. A. Conlon, S. T. Mutuma, M. Arnold, N. W. Read, G. Meijer, and J. Francis. 2000. The effects of intestinal infusion of long-chain fatty acids on food intake in humans. Gastroenterology. 119: 943-948.
21. Matzinger, D., L. Degen, J. Drewe, J. Meuli, R. Duebendorfer, N. Ruckstuhl, M. D'Amato, L. Rovati, and C. Beglinger. 2000. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut. 46: 688-693.
22. Castiglione, K. E., N. W. Read, and S. J. French. 1998. Food intake responses to upper gastrointestinal lipid infusions in humans. Physiol. Behav. 64: 141-145.
23. Drewe, J., A. Gadient, L. C. Rovati, and C. Beglinger. 1992. Role of circulating cholecystokinin in control of fat-induced inhibition of food intake in humans. Gastroenterology. 102: 1654-1659.
24. Greenberg, D., G. P. Smith, and J. Gibbs. 1990. Intraduodenal infusions of fats elicit satiety in sham-feeding rats. Am. J. Physiol. 259: R110-R118.
25. Welch, I. M., C. P. Sepple, and N. W. Read. 1988. Comparisons of the effects on satiety and eating behaviour of infusion of lipid into the different regions of the small intestine. Gut. 29: 306-311.
26. Woltman, T., and R. Reidelberger. 1995. Effects of duodenal and distal ileal infusions of glucose and oleic acid on meal patterns in rats. Am. J. Physiol. 269: R7-R14.
27. Hooper, L. V., M. H. Wong, A. Thelin, L. Hansson, P. G. Falk, and J. I. Gordon. 2001. Molecular analysis of commensal host-microbial relationships in the intestine. Science. 291: 881-884.
28. Winzell Sorhede, M., M. E. Lowe, and C. Erlanson-Albertsson. 1998. Rat gastric procolipase: sequence, expression and secretion during high-fat feeding. Gastroenterology. 115: 1-8.
29. Zhang, J., K. Kaasik, M. R. Blackburn, and C. C. Lee. 2006. Constant darkness is a circadian metabolic signal in mammals. Nature. 439: 340-343.