Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells

Biochemical and Biophysical Research Communications

Volumn 430, Issue 1, 2013, Pages 381-386

  Jeong, Jin Boo ^a   Lee, Seong Ho ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Colorectal cancer; Cyclin D1; Histone deacetylase 2; Protocatechualdehyde

Indexed keywords

CYCLIN D1; HISTONE DEACETYLASE 2; PROTOCATECHUALDEHYDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; COLORECTAL CANCER; CYCLIN D1 GENE; DOWN REGULATION; ENZYME ACTIVITY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZALDEHYDES; CATECHOLS; COLORECTAL NEOPLASMS; CYCLIN D1; DOWN-REGULATION; HCT116 CELLS; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITORS; HUMANS;

HORDEUM; MUSA ACUMINATA; VITIS;

EID: 84872409678     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.018     Document Type: Article

References (33)

1. Siegel R., Naishadham D., Jemal A. Cancer statistics. CA Cancer J. Clin. 2012, 62(2012):10-29.
2. Wang H., Khor T.O., Shu L., Su Z., Fuentes F., Lee J.H., Kong A.N. Plants against cancer: a review on natural phytochemicals in preventing and treating cancers and their drug ability. Anticancer Agents Med. Chem. 2012.
3. Araujo J.R., Goncalves P., Martel F. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr. Res. 2011, 31:77-87.
4. Etoh H., Murakami K., Yogoh T., Ishikawa H., Fukuyama Y., Tanaka H. Anti-oxidative compounds in barley tea. Biosci. Biotechnol. Biochem. 2004, 68:2616-2618.
5. Mulvena D., Webb E.C., Zerner B. 3, 4-Dihydroxybenzaldehyde a fungistatic substance from green cavendish bananas. Phytochemistry 1969, 8:393-395.
6. Weber B., Hoesch L., Rast D.M. Protocatechualdehyde and other phenols as cell-wall components of grapevine leaves. Phytochemistry 1995, 40:433-437.
7. Zhou Z., Liu Y., Miao A.D., Wang S.Q. Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells. Eur. J. Pharmacol. 2005, 513:1-8.
8. Chang Z.Q., Gebru E., Lee S.P., Rhee M.H., Kim J.C., Cheng H., Park S.C. In vitro antioxidant and anti-inflammatory activities of protocatechualdehyde isolated from phellinus gilvus. J. Nutr. Sci. Vitaminol. (Tokyo) 2011, 57:118-122.
9. Kim K.J., Kim M.A., Jung J.H. Antitumor and antioxidant activity of protocatechualdehyde produced from streptomyces lincolnensis M-20. Arch. Pharmacal. Res. 2008, 31:1572-1577.
10. Lee B.H., Yoon S.H., Kim Y.S., Kim S.K., Moon B.J., Bae Y.S. Apoptotic cell death through inhibition of protein kinase CKII activity by 3, 4-dihydroxybenzaldehyde purified from xanthium strumarium. Nat. Prod. Res. 2008, 22:1441-1450.
11. Marks P.A., Rifkind R.A., Richon V.M., Breslow R., Miller T., Kelly W.K. Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer 2001, 1:194-202.
12. Minucci S., Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer 2006, 6:38-51.
13. Zhu P., Martin E., Mengwasser J., Schlag P., Janssen K.P., Gottlicher M. Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell 2004, 5:455-463.
14. Noh J.H., Jung K.H., Kim J.K., Eun J.W., Bae H.J., Xie H.J., Chang Y.G., Kim M.G., Park W.S., Lee J.Y., Nam S.W. Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins. PLoS One 2011, 6:e28103.
15. Jung K.H., Noh J.H., Kim J.K., Eun J.W., Bae H.J., Xie H.J., Chang Y.G., Kim M.G., Park H., Lee J.Y., Nam S.W. HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins. J. Cell Biochem. 2012, 113:2167-2177.
16. Pang M., Ma L., Liu N., Ponnusamy M., Zhao T.C., Yan H., Zhuang S. Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. J. Cell Biochem. 2011, 112:2138-2148.
17. Fakhry H., Miyamoto T., Kashima H., Suzuki A., Ke H., Konishi I., Shiozawa T. Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells. Human Pathol. 2010, 41:848-858.
18. Alao J.P. The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol. Cancer 2007, 6:24.
19. Bahnassy A.A., Zekri A.R.N., El-Houssini S., El-Shehaby A.M.R., Mahmoud M.R., Abdallah S., El-Serafi M. Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroenterol. 2004, 4.
20. Holland T.A., Elder J., McCloud J.M., Hall C., Deakin M., Fryer A.A., Elder J.B., Hoban P.R. Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21 (WAF1/CIP1) expression and correlates with patient survival. Int. J. Cancer 2001, 95:302-306.
21. Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr. Med. Chem. 2001, 8:1505-1511.
22. Kelly W.K., O'Connor O.A., Marks P.A. Histone deacetylase inhibitors: from target to clinical trials. Expert Opin. Invest. Drugs 2002, 11:1695-1713.
23. Kim B., Kim S.H., Jeong S.J., Sohn E.J., Jung J.H., Lee M.H. Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells. J. Agric. Food. Chem. 2012, 60:9882-9889.
24. Yagi Y., Fushida S., Harada S., Kinoshita J., Makino I., Oyama K., Tajima H., Fujita H., Takamura H., Ninomiya I., Fujimura T., Ohta T., Yashiro M., Hirakawa K. Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line. J. Exp. Clin. Cancer Res. 2010, 29.
25. Hrzenjak A., Moinfar F., Kremser M.L., Strohmeier B., Staber P.B., Zatloukal K., Denk H. Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells. Mol. Cancer Ther. 2006, 5:2203-2210.
26. Beijersbergen R.L., Bernards R. Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins. Biochim. Biophys. Acta 1996, 1287:103-120.
27. Hu J., Colburn N.H. Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. Mol. Cancer Res. 2005, 3:100-109.
28. Schuler S., Fritsche P., Diersch S., Arlt A., Schmid R.M., Saur D., Schneider G. HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells. Mol. Cancer 2010, 9:80.
29. Witt O., Deubzer H.E., Milde T., Oehme I. HDAC family: what are the cancer relevant targets?. Cancer Lett. 2009, 277:8-21.
30. Ogino S., Nosho K., Irahara N., Kure S., Shima K., Baba Y., Toyoda S., Chen L., Giovannucci E.L., Meyerhardt J.A., Fuchs C.S. A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases. Clin. Cancer Res. 2009, 15:4431-4438.
31. Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
32. Lee S.-H., Cekanova M., Baek S.J. Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol. Carcinog. 2008, 47(3):197-208.
33. Mukhopadhyay A., Banerjee S., Stafford L.J., Xia C., Liu M., Aggarwal B.B. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 2002, 21:8852-8861.