Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation

Toxicology

Volumn 304, Issue , 2013, Pages 41-48

  Wu, Hai Lu ^a   Gao, Xin ^a   Jiang, Zong Dan ^a   Duan, Zhao Tao ^a   Wang, Shu Kui ^a   He, Bang Shun ^a   Zhang, Zhen Yu ^a   Xie, Hong Guang ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Adverse drug reaction; Clopidogrel; Gastric injury; GES 1 cell line; P38 MAPK; Tight junction protein; Toxicology

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CLOPIDOGREL; DEXTRAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OCCLUDIN; PROTEIN ZO1; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG PENETRATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; STOMACH INJURY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICROSCOPY, ELECTRON, TRANSMISSION; OCCLUDIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET AGGREGATION INHIBITORS; SIGNAL TRANSDUCTION; TICLOPIDINE; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84872407996     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.11.020     Document Type: Article

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