Long-term, intermittent, insulin-induced hypoglycemia produces marked obesity without hyperphagia or insulin resistance: A model for weight gain with intensive insulin therapy

American Journal of Physiology - Endocrinology and Metabolism

Volumn 304, Issue 2, 2013, Pages

  McNay, Ewan C ^a   Teske, Jennifer A ^b   Kotz, Catherine M ^c,d   Dunn Meynell, Ambrose ^e,f   Levin, Barry E ^e,f   McCrimmon, Rory J ^g   Sherwin, Robert S ^h  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^d University of Minnesota   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF DUNDEE   (United Kingdom)

^h YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Hypoglycemia; Insulin; Obesity

Indexed keywords

INSULIN; MESSENGER RNA; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; BODY WEIGHT; BROWN ADIPOSE TISSUE; COLD; CONTROLLED STUDY; CORE TEMPERATURE; DIABETES MELLITUS; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT MASS; FOOD INTAKE; HYPERPHAGIA; HYPOGLYCEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; MOTOR ACTIVITY; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THERMOGENESIS; WEIGHT GAIN;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HYPERPHAGIA; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; OBESITY; PERIODICITY; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; TIME FACTORS; WEIGHT GAIN;

EID: 84872400886     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00262.2012     Document Type: Article

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