Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia

Diabetes

Volumn 52, Issue 3, 2003, Pages 605-613

  Flanagan, Daniel E ^a   Keshavarz, Tara ^a   Evans, Mark L ^a   Flanagan, Sally ^a   Fan, Xiaoning ^a   Jacob, Ralph J ^a   Sherwin, Robert S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ACTH, adrenocorticotrophic hormone; CRH, corticotrophin releasing hormone; CRHr1, corticotrophin releasing hormone receptor 1; HPA, hypothalamic pituitary adrenal; ICV, intracerebroventricular

Indexed keywords

ADRENALIN; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; GLUCOCORTICOID; NORADRENALIN;

ARTICLE; AUTONOMIC DYSFUNCTION; CONTROLLED STUDY; DOWN REGULATION; GLUCOSE CLAMP TECHNIQUE; HORMONAL REGULATION; HORMONE ACTION; HYPERINSULINEMIA; HYPOGLYCEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BLOOD GLUCOSE; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; EPINEPHRINE; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; HOMEOSTASIS; HYPOGLYCEMIA; INSULIN; KINETICS; MALE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 0037342586     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.605     Document Type: Article

References (50)

1. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
2. UK Prospective Diabetes Study (UKPDS) Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837-853, 1998
3. Cryer PE: Banting lecture. Hypoglycemia: the limiting factor in the management of IDDM. Diabetes 43:1378-1389, 1994
4. Pramming S, Thorsteinsson B, Bendtson I, Binder C: Symptomatic hypoglycaemia in 411 type 1 diabetic patients. Diabet Med 8:217-222, 1991
5. The Diabetes Control and Complications Trial Research Group: Hypoglycemia in the Diabetes Control and Complications Trial. Diabetes 46:2710-286, 1997
6. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS: Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med 316:1376-1383, 1987
7. Powell AM, Sherwin RS, Shulman GI: Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits. J Clin Invest 92:2667-2674, 1993
8. Cryer PE: Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. Diabetes 41:255-260, 1992
9. Heller SR, Cryer PE: Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans. Diabetes 40:223-226, 1991
10. Davis MR, Shamoon H: Counterregulatory adaptation to recurrent hypoglycemia in normal humans. J Clin Endocrinol Metab 73:995-1001, 1991
11. Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37:901-907, 1988
12. Lingenfelser T, Buettner U, Martin J, Tobis M, Renn W, Kaschel R, Jakober B: Improvement of impaired counterregulatory hormone response and symptom perception by short-term avoidance of hypoglycemia in IDDM. Diabetes Care 18:321-325, 1995
13. Davis MR, Mellman M, Shamoon H: Further defects in counterregulatory responses induced by recurrent hypoglycemia in IDDM. Diabetes 41:1335-1340, 1992
14. George E, Marques JL, Harris ND, Macdonald IA, Hardisty C, Heller SR: Preservation of physiological responses to hypoglycemia 2 days after antecedent hypoglycemia in patients with IDDM. Diabetes Care 20:1293-1298, 1997
15. Dagogo-Jack SE, Craft S, Cryer PE: Hypoglycemia associated autonomic failure in insulin dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. J Clin Invest 91:819-828, 1993
16. Gerich J, Langlois M, Noacco C, Karam J, Forsham P: Lack of a glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha-cell defect. Science 182:171-173, 1973
17. De Feo P, Bolli G, Perriello G, De CS, Compagnucci P, Angeletti G, Santeusanio F, Gerich JE, Motolese M, Brunetti P: The adrenergic contribution to glucose counterregulation in type I diabetes mellitus. Dependency on A-cell function and mediation through beta 2-adrenergic receptors. Diabetes 32:887-893, 1983
18. Aizawa T, Yasuda N, Greer MA: Hypoglycemia stimulates ACTH secretion through a direct effect on the basal hypothalamus. Metab Clin Exp 30:996-1000, 1981
19. Chrousos GP, Gold PW: The concepts of stress and stress system disorders. Overview of physical and behavioral homeostatis. JAMA 267:1244-1252, 1992
20. Axelrod J, Reisine TD: Stress hormones: their interaction and regulation. Science 224:452-459, 1984
21. Brown MR, Fisher LA: Corticotropin-releasing factor: effects on the autonomic nervous system and visceral systems. Fed Proc 44:243-248, 1985
22. Owens MJ, Nemeroff CB: Physiology and pharmacology of corticotropinreleasing factor. Pharmacol Rev 43:425-473, 1991
23. Davis SN, Shavers C, Costa F, Mosqueda-Garcia R: Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans. J Clin Invest 98:680-691, 1996
24. Davis SN, Shavers C, Davis B, Costa F: Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses. J Clin Invest 100:429-438, 1997
25. Komesaroff PA, Funder JW: Differential glucocorticoid effects on catecholamine responses to stress. Am J Physiol 266:E118-128, 1994
26. Rossetti L, Smith D, Shulman G, Papachristou D, DeFronzo R: Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79:1510-1515, 1987
27. Amiel SA, Tamborlane WV, Sacca L, Sherwin RS: Hypoglycemia and glucose counterregulation in normal and insulin-dependent diabetic subjects. Diabetes Metab Rev 4:71-89, 1988
28. Gerich JE, Campbell PJ: Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions. Diabetes Metab Rev 4:93-111, 1988
29. Bolli G, de Feo P, Compagnucci P, Cartechini MG, Angeletti G, Santeusanio F, Brunetti P, Gerich JE: Abnormal glucose counterregulation in insulindependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32:134-141, 1983
30. White NH, Skor DA, Cryer PE, Levandoski LA, Bier DM, Santiago JV: Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308:485-491, 1983
31. Shum K, Inouye K, Chan O, Mathoo J, Bilinski D, Mathews SG, Vranic M: Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation. Am J Physiol 281:E455-E465, 2001
32. Evans SB, Wilkinson CW, Bentson K, Gronbeck P, Zavosh A, Figlewicz DP: PVN activation is suppressed by repeated hypoglycemia but not antecedent corticosterone in the rat. Am J Physiol 28:R1426-R1436, 2001
33. McGregor VP, Banarer S, Cryer PE: Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia. Am J Physiol 282:E770-E777, 2002
34. Cunningham JJ, Meara PA, Lee RY, Bode HH: Chronic intracerebroventricular CRF infusion attenuates ACTH-corticosterone release. Am J Physiol 255:E213-E217, 1988
35. Evans SB, Wilkinson CW, Gronbeck P, Bennett J, Figlewicz Lattemann DP: Hypothalamic paraventricular nucleus inactivation partially simulates the impaired neuroendocrine response of hypoglycemia associated autonomic failure. Diabetes 51 (Suppl. 2):590P, 2002
36. Szemeredi K, Bagdy G, Stull R, Calogero AE, Kopin IJ, Goldstein DS: Sympathoadrenomedullary inhibition by chronic glucocorticoid treatment in conscious rats. Endocrinology 123:2585-2590, 1988
37. Wurtman RJ, Axelrod J: Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids. J Biol Chem 241:2301-2305, 1966
38. Simonyi A, Fekete MI, Kenessey A, Paldi-Haris P, Graf L: Prolonged ACTH treatment increases trypsin-like and phenylethanolamine-N-methyltransferase (PNMT) activity in the adrenals. Eur J Pharmacol 106:465-466, 1984
39. Brown MR, Fisher LA, Spiess J, Rivier C, Rivier J, Vale W: Corticotropinreleasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 111:928-931, 1982
40. Saunders WS, Thornhill JA: Pressor, tachycardic and behavioral excitatory responses in conscious rats following ICV administration of ACTH and CRF are blocked by naloxone pretreatment. Peptides 7:597-601, 1986
41. Borsody MK, Weiss JM: Influence of corticotropin-releasing hormone on electrophysiological activity of locus coeruleus neurons. Brain Res 724:149-168, 1996
42. Butler PD, Weiss JM, Stout JC, Nemeroff CB: Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus. J Neurosci 10:176-183, 1990
43. Dunn AJ, Berridge CW: Corticotropin-releasing factor administration elicits a stress-like activation of cerebral catecholaminergic systems. Pharmacol Biochem Behav 27:685-691, 1987
44. Ellis MJ, Schmidli RS, Donald RA, Livesey JH, Espiner EA: Plasma corticotrophin-releasing factor and vasopressin responses to hypoglycaemia in normal man. Clin Endocrinol 32:93-100, 1990
45. Martins JM, Kastin AJ, Banks WA: Unidirectional specific and modulated brain to blood transport of corticotropin-releasing hormone. Neuroendocrinology 63:338-348, 1996
46. Wang L, Martinez V, Vale W, Tache Y: Fos induction in selective hypothalamic neuroendocrine and medullary nuclei by intravenous injection of urocortin and corticotropin-releasing factor in rats. Brain Res 855:47-57, 2000
47. Bruhn TO, Engeland WC, Anthony EL, Gann DS, Jackson IM: Corticotropin-releasing factor in the adrenal medulla. Ann N Y Acad Sci 512:115-128, 1987
48. Kishimoto T, Radulovic J, Radulovic M, Lin CR, Schrick C, Hooshmand F, Hermanson O, Rosenfeld MG, Spiess J: Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2. Nat Genet 24:415-419, 2000
49. Webster EL, Lewis DB, Torpy DJ, Zachman EK, Rice KC, Chrousos GP: In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 137:5747-5750, 1996
50. Goldstein DS, Garty M, Bagdy G, Szemeredi K, Sternberg EM, Listwak S, Pacak K, Deka-Starosta A, Hoffman A, Chang PC: Role of CRH in glucopenia-induced adrenomedullary activation in rats. J Neuroendocrinol 5:475-486, 1993