Identification of ZNF395 as a novel modulator of adipogenesis

Experimental Cell Research

Volumn 319, Issue 3, 2013, Pages 68-76

  Hasegawa, Ryota ^a,b   Tomaru, Yasuhiro ^a   de Hoon, Michiel ^a   Suzuki, Harukazu ^a   Hayashizaki, Yoshihide ^a,b   Shin, Jay W ^a  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Adipogenesis; Transcription regulation; Zinc finger proteins

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZNF 395 PROTEIN;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; CELL COUNT; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DRUG IDENTIFICATION; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MICROARRAY; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

EID: 84872395865     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.11.003     Document Type: Article

References (32)

1. Medina-Gomez G., Vidal-Puig A. Adipose tissue as a therapeutic target in obesity. Endocrinol. Nutr. 2009, 56:404-411.
2. Freytag S.O., Paielli D.L., Gilbert J.D. Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Gene Dev. 1994, 8:1654-1663.
3. Chiesi M., Huppertz C., Hofbauer K.G. Pharmacotherapy of obesity: targets and perspectives. Trend Pharmacol. Sci. 2001, 22:247-254.
4. Boss O., Bergenhem N. Adipose targets for obesity drug development. Expert Opin. Ther. Target 2006, 10:119-134.
5. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
6. Tontonoz P., Hu E., Graves R.A., Budavari A.I., Spiegelman B.M. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Gene Dev. 1994, 8:1224-1234.
7. Lazar M.A. PPARy in adipocyte differentiation. J. Anim. Sci. 1999, 77(Suppl. 3):S16-S22.
8. Suzuki H., Forrest A.R., van Nimwegen E., Daub C.O., Balwierz P.J., Irvine K.M., Lassmann T., Ravasi T., Hasegawa Y., de Hoon M.J., Katayama S., Schroder K., Carninci P., Tomaru Y., Kanamori-Katayama M., Kubosaki A., Akalin A., Ando Y., Arner E., Asada M., Asahara H., Bailey T., Bajic V.B., Bauer D., Beckhouse A.G., Bertin N., Bjorkegren J., Brombacher F., Bulger E., Chalk A.M., Chiba J., Cloonan N., Dawe A., Dostie J., Engstrom P.G., Essack M., Faulkner G.J., Fink J.L., Fredman D., Fujimori K., Furuno M., Gojobori T., Gough J., Grimmond S.M., Gustafsson M., Hashimoto M., Hashimoto T., Hatakeyama M., Heinzel S., Hide W., Hofmann O., Hornquist M., Huminiecki L., Ikeo K., Imamoto N., Inoue S., Inoue Y., Ishihara R., Iwayanagi T., Jacobsen A., Kaur M., Kawaji H., Kerr M.C., Kimura R., Kimura S., Kimura Y., Kitano H., Koga H., Kojima T., Kondo S., Konno T., Krogh A., Kruger A., Kumar A., Lenhard B., Lennartsson A., Lindow M., Lizio M., Macpherson C., Maeda N., Maher C.A., Maqungo M., Mar J., Matigian N.A., Matsuda H., Mattick J.S., Meier S., Miyamoto S., Miyamoto-Sato E., Nakabayashi K., Nakachi Y., Nakano M., Nygaard S., Okayama T., Okazaki Y., Okuda-Yabukami H., Orlando V., Otomo J., Pachkov M., Petrovsky N., Plessy C., Quackenbush J., Radovanovic A., Rehli M., Saito R., Sandelin A., Schmeier S., Schonbach C., Schwartz A.S., Semple C.A., Sera M., Severin J., Shirahige K., Simons C., St Laurent G., Suzuki M., Suzuki T., Sweet M.J., Taft R.J., Takeda S., Takenaka Y., Tan K., Taylor M.S., Teasdale R.D., Tegner J., Teichmann S., Valen E., Wahlestedt C., Waki K., Waterhouse A., Wells C.A., Winther O., Wu L., Yamaguchi K., Yanagawa H., Yasuda J., Zavolan M., Hume D.A., Arakawa T., Fukuda S., Imamura K., Kai C., Kaiho A., Kawashima T., Kawazu C., Kitazume Y., Kojima M., Miura H., Murakami K., Murata M., Ninomiya N., Nishiyori H., Noma S., Ogawa C., Sano T., Simon C., Tagami M., Takahashi Y., Kawai J., Hayashizaki Y. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat. Genet. 2009, 41:553-562.
9. Chen Z., Torrens J.I., Anand A., Spiegelman B.M., Friedman J.M. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab. 2005, 1:93-106.
10. Birsoy K., Chen Z., Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metab. 2008, 7:339-347.
11. Meruvu S., Hugendubler L., Mueller E. Regulation of adipocyte differentiation by the zinc finger protein ZNF638. J. Biol. Chem. 2011, 286:26516-26523.
12. Vierbuchen T., Ostermeier A., Pang Z.P., Kokubu Y., Sudhof T.C., Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010, 463:1035-1041.
13. Zhou Q., Brown J., Kanarek A., Rajagopal J., Melton D.A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008, 455:627-632.
14. Tontonoz P., Hu E., Spiegelman B.M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994, 79:1147-1156.
15. Ieda M., Fu J.D., Delgado-Olguin P., Vedantham V., Hayashi Y., Bruneau B.G., Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010, 142:375-386.
16. Suzuki T., Nakano-Ikegaya M., Yabukami-Okuda H., de Hoon M., Severin J., Saga-Hatano S., Shin J.W., Kubosaki A., Simon C., Hasegawa Y., Hayashizaki Y., Suzuki H. Reconstruction of monocyte transcriptional regulatory network accompanies monocytic functions in human fibroblasts. PLoS One 2012, 7:e33474.
17. Pachkov M., Erb I., Molina N., van Nimwegen E. SwissRegulon: a database of genome-wide annotations of regulatory sites. Nucleic Acid Res. 2007, 35:D127-131.
18. van Nimwegen E. Finding regulatory elements and regulatory motifs: a general probabilistic framework. BMC Bioinf. 2007, 8(Suppl. 6):S4.
19. Wain H.M., Lush M., Ducluzeau F., Povey S. Genew: the human gene nomenclature database. Nucleic Acid Res. 2002, 30:169-171.
20. Gupta R.K., Arany Z., Seale P., Mepani R.J., Ye L., Conroe H.M., Roby Y.A., Kulaga H., Reed R.R., Spiegelman B.M. Transcriptional control of preadipocyte determination by ZFP423. Nature 2010, 464:619-623.
21. Tanaka K., Shouguchi-Miyata J., Miyamoto N., Ikeda J.E. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. J. Biol. Chem. 2004, 279:7275-7286.
22. Sichtig N., Korfer N., Steger G. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. Arch. Biochem. Biophys. 2007, 467:67-75.
23. Westerberg R., Tvrdik P., Unden A.B., Mansson J.E., Norlen L., Jakobsson A., Holleran W.H., Elias P.M., Asadi A., Flodby P., Toftgard R., Capecchi M.R., Jacobsson A. Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J. Biol. Chem. 2004, 279:5621-5629.
24. Suzuki H., Kawarabayasi Y., Kondo J., Abe T., Nishikawa K., Kimura S., Hashimoto T., Yamamoto T. Structure and regulation of rat long-chain acyl-CoA synthetase. J. Biol. Chem. 1990, 265:8681-8685.
25. Kawato Y., Hirao M., Ebina K., Shi K., Hashimoto J., Honjo Y., Yoshikawa H., Myoui A. Nkx3.2 promotes primary chondrogenic differentiation by upregulating col2a1 transcription. PLoS One 2012, 7:e34703.
26. Ganss B., Jheon A. Zinc finger transcription factors in skeletal development. Crit. Rev. Oral Biol. Med. 2004, 15:282-297.
27. Aruga J. The role of Zic genes in neural development. Mol. Cell Neurosci. 2004, 26:205-221.
28. Sen G.L., Boxer L.D., Webster D.E., Bussat R.T., Qu K., Zarnegar B.J., Johnston D., Siprashvili Z., Khavari P.A. ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev. Cell 2012, 22:669-677.
29. Geiger K., Leiherer A., Muendlein A., Stark N., Geller-Rhomberg S., Saely C.H., Wabitsch M., Fraunberger P., Drexel H. Identification of hypoxia-induced genes in human SGBS adipocytes by microarray analysis. PLoS One 2011, 6:e26465.
30. Pei H., Yao Y., Yang Y., Liao K., Wu J.R. Kruppel-like factor KLF9 regulates PPARgamma transactivation at the middle stage of adipogenesis. Cell Death Differ. 2011, 18:315-327.
31. Mori T., Sakaue H., Iguchi H., Gomi H., Okada Y., Takashima Y., Nakamura K., Nakamura T., Yamauchi T., Kubota N., Kadowaki T., Matsuki Y., Ogawa W., Hiramatsu R., Kasuga M. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J. Biol. Chem. 2005, 280:12867-12875.
32. Shin J.W., Suzuki T., Ninomiya N., Kishima M., Hasegawa Y., Kubosaki A., Yabukami H., Hayashizaki Y., Suzuki H. Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming. Nucleic Acids Res. 2012, 1-9.