The retrograde delivery of adenovirus vector carrying the gene for brain-derived neurotrophic factor protects neurons and oligodendrocytes from apoptosis in the chronically compressed spinal cord of twy/twy mice

Spine

Volumn 37, Issue 26, 2012, Pages 2125-2135

  Uchida, Kenzo ^a   Nakajima, Hideaki ^a   Hirai, Takayuki ^a   Yayama, Takafumi ^a   Chen, Kebing ^a   Guerrero, Alexander Rodriguez ^a   Johnson, William Eustace ^b   Baba, Hisatoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b ASTON UNIVERSITY   (United Kingdom)

Author keywords

Adenoviral vector (AdV); Brain derived neurotrophic factor (BDNF); Chronic compression; Gene transfer; Retrograde; Spinal cord

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CASPASE 8; CASPASE 9; CELL MARKER; CELL MARKER NG2; GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROFILAMENT PROTEIN; NEUROTROPHIN RECEPTOR P75; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CELL SPECIFICITY; CERVICAL SPINAL CORD; CHRONIC DISEASE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSFECTION; GLIA CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROGLIA; MOTONEURON; MOUSE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD COMPRESSION; SPINAL CORD NERVE CELL; STERNOCLEIDOMASTOID MUSCLE; VIRAL GENE DELIVERY SYSTEM; WHITE MATTER;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; GENETIC THERAPY; GENETIC VECTORS; HYPEROSTOSIS; MICE; NEURONS; OLIGODENDROGLIA; SPINAL CORD; SPINAL CORD COMPRESSION;

EID: 84872388659     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3182600ef7     Document Type: Article

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