N-myc downstream-regulated gene 1 is involved in the regulation of cystogenesis in transgenic mice overexpressing human PKD2 gene

Proteomics

Volumn 13, Issue 1, 2013, Pages 134-141

  Kim, Bo Hye ^a   Park, Eun Young ^a   Yoo, Kyung Hyun ^a,c   Choi, Kyung Mi ^b   Kim, Yona ^b   Seong, Je kyung ^b   Park, Jong Hoon ^a  

^a Sookmyung Women's University   (South Korea)

^b Seoul National University   (South Korea)

^c not available   (United States)

Author keywords

ADPKD; Animal proteomics; Cystogenesis; NDRG1; PKD2 transgenic mouse; Proliferation

Indexed keywords

N MYC DOWNSTREAM REGULATED GENE 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE OVEREXPRESSION; GENE SILENCING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KIDNEY CYST; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 84872386909     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201200248     Document Type: Article

References (27)

1. Torres, V. E., Harris, P. C., Mechanisms of disease: autosomal dominant and recessive polycystic kidney diseases. Nat. Clin. Pract. Nephrol. 2006, 2, 40-55; quiz 55.
2. Park, E. Y., Woo, Y. M., Park, J. H., Polycystic kidney disease and therapeutic approaches. BMB Rep. 2011, 44, 359-368.
3. Ibraghimov-Beskrovnaya, O., Bukanov, N., Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies. Cell Mol. Life Sci. 2008, 65, 605-619.
4. Braun, W. E., Autosomal dominant polycystic kidney disease: emerging concepts of pathogenesis and new treatments. Cleve. Clin. J. Med. 2009, 76, 97-104.
5. Pennekamp, P., Karcher, C., Fischer, A., Schweickert, A. et al., The ion channel polycystin-2 is required for left-right axis determination in mice. Curr. Biol. 2002, 12, 938-943.
6. Nishio, S., Hatano, M., Nagata, M., Horie, S. et al., Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. J. Clin. Invest. 2005, 115, 910-918.
7. Thivierge, C., Kurbegovic, A., Couillard, M., Guillaume, R. et al., Overexpression of PKD1 causes polycystic kidney disease. Mol. Cell Biol. 2006, 26, 1538-1548.
8. Burtey, S., Riera, M., Ribe, E., Pennekamp, P. et al., Overexpression of PKD2 in the mouse is associated with renal tubulopathy. Nephrol. Dial Transplant 2008, 23, 1157-1165.
9. Park, E. Y., Sung, Y. H., Yang, M. H., Noh, J. Y. et al., Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice. J. Biol. Chem. 2009, 284, 7214-7222.
10. Ellen, T. P., Ke, Q., Zhang, P., Costa, M., NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis 2008, 29, 2-8.
11. Chen, B., Nelson, D. M., Sadovsky, Y., N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. J. Biol. Chem. 2006, 281, 2764-2772.
12. Zhao, G., Chen, J., Deng, Y., Gao, F. et al., Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cells. Biochem. Biophys. Res. Commun. 2011, 408, 154-159.
13. Liu, Y. L., Bai, W. T., Luo, W., Zhang, D. X. et al., Downregulation of NDRG1 promotes invasion of human gastric cancer AGS cells through MMP-2. Tumour Biol. 2011, 32, 99-105.
14. Kovacevic, Z., Richardson, D. R., The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer. Carcinogenesis 2006, 27, 2355-2366.
15. Cheng, J., Xie, H. Y., Xu, X., Wu, J. et al., NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma. Cancer Lett. 2011, 310, 35-45.
16. Yoo, K. H., Kim, Y. N., Lee, M. J., Seong, J. K., Park, J. H., Identification of apolipoproteinA1 reduction in the polycystic kidney by proteomics analysis of the Mxi1-deficient mouse. Proteomics 2009, 9, 3824-3832.
17. Takiar, V., Nishio, S., Seo-Mayer, P., King, J. D., Jr. et al., Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc. Natl. Acad. Sci. USA 2011, 108, 2462-2467.
18. Zhang, P., Tchou-Wong, K. M., Costa, M., Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter. Cancer Res. 2007, 67, 9125-9133.
19. Melotte, V., Qu, X., Ongenaert, M., van Criekinge, W. et al., The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB J. 2010, 24, 4153-4166.
20. Chen, J., Li, S., Yang, Z., Lu, G., Hu, H., Correlation between NDRG1 and PTEN expression in endometrial carcinoma. Cancer Sci. 2008, 99, 706-710.
21. Mao, X. Y., Fan, C. F., Wei, J., Liu, C. et al., Increased N-myc downstream-regulated gene 1 expression is associated with breast atypia-to-carcinoma progression. Tumour Biol. 2011, 32, 1271-1276.
22. Masuda, K., Ono, M., Okamoto, M., Morikawa, W. et al., Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells. Int. J. Cancer 2003, 105, 803-810.
23. Carl, M., Akagi, Y., Weidner, S., Isaka, Y. et al., Specific inhibition of Egr-1 prevents mesangial cell hypercellularity in experimental nephritis. Kidney Int. 2003, 63, 1302-1312.
24. Chang, J. S., Wendt, T., Qu, W., Kong, L. et al., Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 2008, 102, 905-913.
25. Zeng, S., Dun, H., Ippagunta, N., Rosario, R. et al., Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury. J. Hepatol. 2009, 50, 929-936.
26. Xu, Y., Toure, F., Qu, W., Lin, L. et al., Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages. J. Biol. Chem. 2010, 285, 23233-23240.
27. Park, E. Y., Seo, M. J., Park, J. H., Effects of specific genes activating RAGE on polycystic kidney disease. Am. J. Nephrol. 2010, 32, 169-178.