Constitutive expression of pregnancy-associated plasma protein-A in arterial smooth muscle reduces the vascular response to injury in vivo

American Journal of Physiology - Endocrinology and Metabolism

Volumn 304, Issue 2, 2013, Pages

  Bale, Laurie K ^a   Resch, Zachary T ^a   Harstad, Sara L ^a   Overgaard, Michael T ^b   Conover, Cheryl A ^a  

^a Mayo Clinic College of Medicine   (United States)

^b AALBORG UNIVERSITY   (Denmark)

Author keywords

Carotid ligatio; Hyperplasia; Insulin like growth factor I; Pregnancy associated plasma protein A; Restenosis; Vascular smooth muscle cells

Indexed keywords

CELL MARKER; MESSENGER RNA; PREGNANCY ASSOCIATED PLASMA PROTEIN A; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; BLOOD VESSEL REACTIVITY; CAROTID ARTERY INJURY; CAROTID ARTERY LIGATION; CELL DEDIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG ACTIVITY; GENE OVEREXPRESSION; IMMUNOHISTOLOGY; IN VIVO STUDY; MORPHOMETRICS; MOUSE; NEOINTIMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ARTERIES; CAROTID ARTERY INJURIES; GENE EXPRESSION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; ORGAN SPECIFICITY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; RNA, MESSENGER; TRANSFECTION; TUNICA INTIMA;

EID: 84872386376     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00376.2012     Document Type: Article

References (32)

1. Bayes-Genis A, Conover CA, Schwartz RS. The insulin-like growth factor axis: a review of atherosclerosis and restenosis. Circ Res 86: 125-130, 2000.
2. Bayes-Genis A, Schwartz RS, Bale LK, Conover CA. Effects of insulin-like growth factor-I on cultured human coronary artery smooth muscle cells. Growth Horm IGF Res 13: 246-253, 2003.
3. Bayes-Genis A, Schwartz RS, Lewis DA, Overgaard MT, Christiansen M, Oxvig C, Ashai K, Holmes DR Jr, Conover CA. Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty. Arterioscler Thromb Vasc Biol 21: 335-341, 2001.
4. Boldt HB, Conover CA. Pregnancy-associated plasma protein-A (PAPPA): a local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm IGF Res 17: 10-18, 2007.
5. Boldt HB, Overgaard MT, Laursen LS, Weyer K, Sottrup-Jensen L, Oxvig C. Mutational analysis of the proteolytic domain of pregnancyassociated plasma protein-A (PAPP-A): classification as a metzincin. Biochem J 358: 359-367, 2001.
6. Breen DM, Chan KK, Dhaliwall JK, Ward MR, Koudsi NA, Lam L, De Souza M, Ghanim H, Dandona P, Stewart DJ, Bendeck MP, Giacca A. Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury. Arterioscler Thromb Vasc Biol 29: 1060-1066, 2009.
7. Cercek B, Fishbein MC, Forrester JS, Helfant RH, Fagin JA. Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation. Circ Res 66: 1755-1760, 1990.
8. Clemmons DR. Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer. Nat Rev Drug Discov 6: 821-833, 2007.
9. Conover CA, Mason MA, Bale LK, Harrington SC, Nyegaard M, Oxvig C, Overgaard MT. Transgenic overexpression of pregnancyassociated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development. Am J Physiol Heart Circ Physiol 299: H284-H291, 2010.
10. Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 24: 435-444, 2004.
11. Duan C, Hawes SB, Prevette T, Clemmons DR. Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells. J Biol Chem 271: 4280-4288, 1996.
12. Endres M, Piriz J, Gertz K, Harms C, Meisel A, Kronenberg G, Torres-Aleman I. Serum insulin-like growth factor I and ischemic brain injury. Brain Res 1185: 328-335, 2007.
13. Frystyk J, Ledet T, Møller N, Flyvbjerg A, Orskov H. Cardiovascular disease and insulin-like growth factor I. Circulation 106: 893-895, 2000.
14. Grant MB, Wargovich TJ, Ellis AE, Tarnuzzer R, Caballero S, Estes K, Rossing M, Spoerri PE, Pepine C. Expression of IGF-I, IGF-I receptor and IGF binding proteins-1, -2, -3, -4 and -5 in human atherectomy specimens. Regul Pept 67: 137-144, 1996.
15. Grundmann O, Fillinger JL, Victory KR, Burd R, Limesand KH. Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration. BMC Cancer 10: 417-425, 2010.
16. Harmon KJ, Couper LL, Lindner S. Strain-dependent vascular remodeling phenotypes in inbred mice. Am J Pathol 156: 1741-1748, 2000.
17. Harrington SC, Simari RD, Conover CA. Genetic deletion of pregnancy- associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 100: 1696-1702, 2007.
18. Khorsandi M, Fagin JA, Fishbein MC, Forrester JS, Cercek B. Effects of hypophysectomy on vascular insulin-like growth factor-I gene expression after balloon denudation in rats. Atherosclerosis 93: 115-122, 1992.
19. Kumar A, Lindner V. Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow. Arterioscler Thromb Vasc Biol 17: 2238-2244, 1997.
20. Mitchell G, Fillinger J, Sittadjody S, Avila J, Burd R, Limesand K. IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter. Cell Death Dis 1: e50-e59, 2010.
21. Nichols TC, du Laney T, Zheng B, Bellinger DA, Nickols GA, Engleman W, Clemmons DR. Reduction in atherosclerotic lesion size in pigs by alphaVbeta3 inhibitors is associated with inhibition of insulin-like growth factor-I-mediated signaling. Circ Res 85: 1040-1045, 1999.
22. O'Donnell SL, Frederick TJ, Krady JK, Vannucci SJ, Wood TL. IGF-I and microglia/macrophage proliferation in the ischemic mouse brain. Glia 38: 85-97, 2002.
23. Prele CM, Reichelt ME, Mutsaers SE, Davies M, Delbridge LM, Headrick JP, Rosenthal N, Bogoyevitch MA, Grounds MD. Insulinlike growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia. Cardiovasc Pathol 21: 17-27, 2012.
24. Qin X, Wergedal JE, Rehage M, Tran K, Newton J, Lam P, Baylink DJ, Mohan S. Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo. Endocrinology 147: 5653-5661, 2006.
25. Regan CP, Adam PJ, Madsen CS, Owens GK. Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury. J Clin Invest 106: 1139-1147, 2000.
26. Rehage M, Mohan S, Wergedal JE, Bonafede B, Tran K, Hou D, Phang D, Kumar A, Qin X. Transgenic overexpression of pregnancyassociated plasma protein-A increases the somatic growth and skeletal muscle mass in mice. Endocrinology 148: 6176-6185, 2007.
27. Resch ZT, Simari RD, Conover CA. Targeted disruption of the pregnancy- associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury. Endocrinology 147: 5634-5640, 2006.
28. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 182: 311-322, 2000.
29. Wamhoff BR, Hoofnagle MH, Burns A, Sinha S, McDonald OG, Owens GK. A G/C element mediates repression of the SM22α promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circ Res 95: 981-988, 2004.
30. Wong AH, Amabile PG, Yuksel E, Waugh JM, Dake MD. Perivascular release of insulin-like growth factor-1 limits neointima formation in the balloon-injured artery by redirecting smooth muscle cell migration. J Vasc Interv Radiol 12: 347-350, 2001.
31. Zhao G, Sutliff RL, Weber CS, Wang J, Lorenz J, Paul RJ, Fagin JA. Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility. Endocrinology 142: 623-632, 2001.
32. Zhu B, Zhao G, Witte DP, Hui DY, Fagin JA. Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury. Endocrinology 142: 3598-3606, 2001.