Investigation of the hepatoprotective effects of sesame (Sesamum indicum L.) in carbon tetrachloride-induced liver toxicity

Journal of Membrane Biology

Volumn 246, Issue 1, 2013, Pages 1-6

  Cengiz, Nureddin ^a   Kavak, Servet ^a   Güzel, Ali ^b   Özbek, Hanefi ^c   Bektaş, Hava ^a   Him, Aydin ^d   Erdoǧan, Ender ^e   Balahoroǧlu, Ragib ^e  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

^b State Hospital   (Turkey)

^c MINISTRY OF HEALTH   (Turkey)

^d ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^e SELCUK UNIVERSITY   (Turkey)

Author keywords

ALP; ALT; AST; Carbon tetrachloride; Histology; Liver; Rat; Sesame; Sesamum indicum L.

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; FAT DROPLET; SESAME SEED OIL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; HISTOPATHOLOGY; LIVER INJURY; LIVER PARENCHYMA; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT; SESAME;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; LIVER; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SESAMUM;

RATTUS; SESAMUM INDICUM;

EID: 84872383811     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-012-9494-7     Document Type: Article

References (36)

1. Al Hamedan WA, Anfenan MLK (2002) Antioxidant activity of leek toward free radical resulting from consumption of carbonated meat in rats. Life Sci J 8:169-176
2. Awobajo FO, Omorodion-Osagie E, Olatunji-Bello II, Adegoke OA, Adeleke TL (2009) Acute oral toxicity and phytochemistry of some West African medicinal plants. Niger Q J Hosp Med 19:320-329
3. Bharali MK, Dutta K (2009) Hepatic histopathological abnormalities in rats treated topically with para-phenylene diamine (PPD). J Pharmacol Toxicol 4:221-228
4. Bhatt AD, Bhatt NS (1996) Indigenous drugs and liver disease. Indian J Gastroenterol 15:63-67
5. Bhattacharyya D, Mukherjee R, Pandit S, Das N, Sur TK (2003) Prevention of carbon tetrachloride induced hepatotoxicity in rats by Himoliv, a polyherbal formulation. Indian J Pharmacol 35:133-135
6. Bishayee A, Sarkar A, Chatterjee M (1995) The hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. J Ethnopharmacol 47:69-74
7. Bown D (1995) Encyclopaedia of herbs and their uses. Dorling Kindersley, London
8. Brattin WJ, Glende EA Jr, Recknagel RO (1985) Pathological mechanisms in carbon tetrachloride hepatotoxicity. J Free Radic Biol Med 1:27-38
9. Cengiz N, Ozbek H, Him A (2008) Hepatoprotective effects of Pimpinella anisum seed extract in rats. Pharmacologyonline 3:870-874
10. Duke JA, Ayensu ES (1985) Medicinal plants of China. Reference Publications, Inc., Algonac, MI
11. Fridovich I (1995) Superoxide dismutases. Ann Rev Biochem 64:97-112
12. Gassó M, Rubio M, Varela G, Cabré M, Caballería J, Alonso E, Deulofem R, Camps J, Giménez A, Pajares M, Parés A, Mato JM, Rodés J (1996) Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis. J Hepatol 25:200-205
13. Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland RS, Hoffman RS (1998) Acetaminophen. In: Smilkstein MJ (ed) Goldfrank's toxicologic emergencies, 6th edn. Appleton and Lange, Norwalk
14. Goth L (1991) A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 196:143-152
15. Handa SS, Sharma A (1990) Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res B 92:276-283
16. 2+-induced permeability transition of mitochondria. Free Radic Res 38:27-35
17. Klein AS, Hart J, Brems JJ, Goldstein L, Lewin K, Busuttil RW (1989) Amanita poisoning: treatment and the role of liver transplantation. Am J Med 86:187-193
18. Lee WM (1995) Drug-induced hepatotoxicity. N Engl J Med 333:1118-1127
19. Lewis MPH (1977) Medical botany: plants affecting man's health. Wiley, New York, pp 217-218
20. Linder MC (1984) Other trace elements and the liver. Semin Liver Dis 4:264-276
21. Momin A (1987) Role of indigenous medicine in primary health care. Paper presented at: 1st International Seminar on Unani Medicine, New Delhi, India, p 54
22. Nadkarni GD, D'Souza NB (1988) Hepatic antioxidant enzymes and lipid peroxidation in carbon tetrachloride-induced liver cirrhosis in rats. Biochem Med Metabol Biol 40:42-45
23. Nagarkatti DS, Rege NN, Desai NK, Dahanukar SA (1994) Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. J Postgrad Med 40:65-67
24. Nwachukwu DC, Okwuosa CN, Chukwu PU, Azubuike N, Udeani T (2011) Hepatoprotective activity of methanol extract of the seeds of Sesamum indicum in carbon tetrachloride induced hepatotoxicity in rats. Indian J Novel Drug Deliv 3:36-42
25. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-169
26. Recknagel RO, Glende EA Jr, Dolak JA, Waller RL (1989) Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther 43:139-154
27. Santra A, Das S, Maity A (1998) Prevention of carbon tetrachloride- induced hepatic injury in mice by Picrorhiza kurroa. Indian J Gastroenterol 17:6-9
28. Shenoy KA, Somayaji SN, Bairy KL (2001) Hepatoprotective effects of Ginkgo biloba against carbon tetrachloride induced hepatic injury in rats. Indian J Pharmacol 33:260-266
29. Slater TF (1965) Biochemical mechanism of liver injury. Academic Press, London
30. Slater TF (1982) Free radicals as reactive intermediates in injury. In: Snyder R, Parke DV, Kocsis JJ, Jollow DJ, Gebson GG, Witmer CM (eds) Biological reactive intermediates II: chemical mechanisms and biological effects. Plenum Press, New York, pp 575-589
31. Srivastava S, Srivastawa AK, Srivastava S, Patnaik GK, Phawan BN (1994) Effect of picroliv and silymarin in liver regeneration in rats. Indian J Pharmacol 24:19-22
32. Suja KP, Jayalekshmy A, Arumughan C (2004) Free radical scavenging behaviour of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH system. J Agric Food Chem 52:912-915
33. Takeoka GR, Dao LT (2003) Antioxidant constituent of almond [Prunus dulicis (Mill.) D.A. Webb] hulls. J Agric Food Chem 51:496-501
34. Wasowicz W, Nève J, Peretz A (1993) Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem 39:2522-2526
35. Wei YH, Lee HC (2002) Oxidative stress, mitochondrial DNA mutation and impairment of antioxidant enzymes in aging. Exp Biol Med 227:671-682
36. 4)-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol Biochem 37:209-216