Dual inhibition of DNA polymerase PolC and protein tyrosine phosphatase CpsB uncovers a novel antibiotic target

Biochemical and Biophysical Research Communications

Volumn 430, Issue 1, 2013, Pages 167-172

  Standish, Alistair J ^a   Salim, Angela A ^b   Capon, Robert J ^b   Morona, Renato ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antibiotic; Bacteria; DNA polymerase; Exonuclease; Polymerase and histidinol phosphate domain

Indexed keywords

ANTIBIOTIC AGENT; CPSB PROTEIN; DNA DIRECTED DNA POLYMERASE GAMMA; EXONUCLEASE; FASCIOQUINOL E; HISTIDINOL PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CATALYSIS; DRUG PURIFICATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DITERPENES; DNA-DIRECTED DNA POLYMERASE; HYDROLYSIS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASES; STREPTOCOCCUS PNEUMONIAE; SULFURIC ACID ESTERS;

POSIBACTERIA;

EID: 84872383258     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.049     Document Type: Article

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