Hydrolytically degradable shells on thermoresponsive microgels

Colloid and Polymer Science

Volumn 291, Issue 1, 2013, Pages 99-107

  Gaulding, Jeffrey C ^a   South, Antoinette B ^a,b   Lyon, L Andrew ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b JAMES MADISON UNIVERSITY   (United States)

Author keywords

Core shell; Degradable; Microgels; Themoresponsive

Indexed keywords

ANALYTICAL TOOL; CHEMICAL CHANGE; COMPRESSIVE FORCES; CORE/SHELL; CROSSLINKER; DEGRADABLE; EROSION PROPERTIES; HYDROLYTIC DEGRADATION; MICRO-GELS; N-ISOPROPYLACRYLAMIDES; PHYSIOLOGIC CONDITIONS; POROUS SHELLS; POTENTIAL UTILITY; THEMORESPONSIVE; THERMO-RESPONSIVE;

ACRYLIC MONOMERS; ATOMIC FORCE MICROSCOPY; CROSSLINKING; DRUG DELIVERY; FUNCTIONAL POLYMERS; GELS;

SHELLS (STRUCTURES);

AMIDE; POLY(N ISOPROPYLACRYLAMIDE); POLY(N ISOPROPYLMETHACRYLAMIDE); POLYMER; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADABILITY; COMPRESSIVE STRENGTH; CROSS LINKING; FORCE; GEL; HYDROLYSIS; PRIORITY JOURNAL; SYNTHESIS; THERMORESPONSIVE MICROGEL;

EID: 84872379771     PISSN: 0303402X     EISSN: 14351536     Source Type: Journal    
DOI: 10.1007/s00396-012-2692-0     Document Type: Article

References (43)

1. Couvreur P, Vauthier C (2006) Nanotechnology: intelligent design to treat complex disease. Pharm Res 23(7):1417-1450. doi: 10.1007/s11095-006-0284-8
2. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R (2007) Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2(12):751-760. doi: 10.1038/nnano.2007.387
3. Goldberg M, Gomez-Orellana I (2003) Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov 2(4):289-295. doi: 10.1038/Nrd1067
4. Torchilin VP (2005) Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 4(2):145-160. doi: 10.1038/Nrd1632
5. Yoon HJ, Jang WD (2010) Polymeric supramolecular systems for drug delivery. J Mater Chem 20(2):211-222. doi: 10.1039/b910948j
6. Ghosh P, Han G, De M, Kim CK, Rotello VM (2008) Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 60(11):1307-1315. doi: 10.1016/j.addr.2008.03.016
7. Nayak S, Lyon LA (2005) Soft nanotechnology with soft nanoparticles. Angew Chem Int Ed 44(47):7686-7708. doi: 10.1002/anie.200501321
8. Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K (2008) The development of microgels/nanogels for drug delivery applications. Prog Polym Sci 33(4):448-477. doi: 10.1016/j.progpolymsci.2008.01.002
9. Kabanov AV, Vinogradov SV (2009) Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew Chem Int Ed 48(30):5418-5429. doi: 10.1002/anie.200900441
10. Raemdonck K, Demeester J, De Smedt S (2009) Advanced nanogel engineering for drug delivery. Soft Matter 5(4):707-715. doi: 10.1039/b811923f
11. Bysell H, Mansson R, Hansson P, Malmsten M (2011) Microgels and microcapsules in peptide and protein drug delivery. Adv Drug Deliv Rev 63(13):1172-1185. doi: 10.1016/j.addr.2011.08.005
12. Park K, Shalaby WSW, Park H (1993) Biodegradable hydrogels for drug delivery. Technomic, Lancaster
13. Klinger D, Landfester K (2011) Photo-sensitive PMMA microgels: light-triggered swelling and degradation. Soft Matter 7(4):1426-1440. doi: 10.1039/c0sm00638f
14. Klinger D, Landfester K (2011) Polymeric photoresist nanoparticles: light-induced degradation of hydrophobic polymers in aqueous dispersion. Macromol Rapid Commun 32(24):1979-1985. doi: 10.1002/marc.201100493
15. Klinger D, Landfester K (2011) Dual stimuli-responsive poly(2-hydroxyethyl methacrylate-co-methacrylic acid) microgels based on photo-cleavable cross-linkers: pH-dependent swelling and light-induced degradation. Macromolecules 44(24):9758-9772. doi: 10.1021/ma201706r
16. Nayak S, Gan DJ, Serpe MJ, Lyon LA (2005) Hollow thermoresponsive microgels. Small 1(4):416-421. doi: 10.1002/smll.200400089
17. Smith MH, Herman ES, Lyon LA (2011) Network deconstruction reveals network structure in responsive microgels. J Phys Chem B 115(14):3761-3764. doi: 10.1021/jp111634k
18. Gaulding JC, Smith MH, Hyatt JS, Fernandez-Nieves A, Lyon LA (2012) Reversible inter- and intra-microgel cross-linking using disulfides. Macromolecules 45:39-45. doi: 10.1021/ma202282p
19. Shantha KL, Ravichandran P, Rao KP (1995) Azo polymeric hydrogels for colon targeted drug delivery. Biomaterials 16(17):1313-1318
20. Ulbrich K, Strohalm J, Kopecek J (1982) Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin. Biomaterials 3(3):150-154
21. Murthy N, Thng YX, Schuck S, Xu MC, Frechet JMJ (2002) A novel strategy for encapsulation and release of proteins: hydrogels and microgels with acid-labile acetal cross-linkers. J Am Chem Soc 124(42):12398-12399. doi: 10.1021/ja026925r
22. Murthy N, Xu MC, Schuck S, Kunisawa J, Shastri N, Frechet JMJ (2003) A macromolecular delivery vehicle for protein-based vaccines: acid-degradable protein-loaded microgels. Proc Natl Acad Sci U S A 100(9):4995-5000. doi: 10.1073/pnas.0930644100
23. Metz N, Theato P (2009) Synthesis and characterization of base labile poly(N-isopropylacrylamide) networks utilizing a reactive cross-linker. Macromolecules 42(1):37-39. doi: 10.1021/ma802279v
24. Ulbrich K, Subr V, Seymour LW, Duncan R (1993) Novel biodegradable hydrogels prepared using the divinylic crosslinking agent N, O-dimethacryloylhydroxylamine. 1. Synthesis and characterization of rates of gel degradation, and rate of release of model-drugs, in vitro and in vivo. J Control Release 24(1):181-190
25. Horak D, Chaykivskyy O (2002) Poly(2-hydroxyethyl methacrylate-co-N, O-dimethacryloylhydroxylamine) particles by dispersion polymerization. J Polym Sci A Polym Chem 40(10):1625-1632. doi: 10.1002/pola.10238
26. Yin WS, Akala EO, Taylor RE (2002) Design of naltrexone-loaded hydrolyzable crosslinked nanoparticles. Int J Pharm 244(1-2):9-19
27. Pradny M, Michalek J, Lesny P, Hejcl A, Vacik J, Slouf M, Sykova E (2006) Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: hydrolytically degradable materials. J Mat Sci-Mat Med 17(12):1357-1364. doi: 10.1007/s10856-006-0611-y
28. Caruso F (2001) Nanoengineering of particle surfaces. Adv Mater 13(1):11-22
29. Schartl W (2010) Current directions in core-shell nanoparticle design. Nanoscale 2(6):829-843. doi: 10.1039/c0nr00028k
30. Cayre OJ, Chagneux N, Biggs S (2011) Stimulus responsive core-shell nanoparticles: synthesis and applications of polymer based aqueous systems. Soft Matter 7(6):2211-2234. doi: 10.1039/c0sm01072c
31. Jones CD, Lyon LA (2000) Synthesis and characterization of multiresponsive core-shell microgels. Macromolecules 33(22):8301-8306. doi: 10.1021/ma001398m
32. Blackburn WH, Dickerson EB, Smith MH, McDonald JF, Lyon LA (2009) Peptide-functionalized nanogels for targeted siRNA delivery. Bioconjug Chem 20(5):960-968. doi: 10.1021/bc800547c
33. Nayak S, Lyon LA (2004) Ligand-functionalized core/shell microgels with permselective shells. Angew Chem Int Ed 43(48):6706-6709. doi: 10.1002/anie.200461090
34. Hendrickson GR, Lyon LA (2010) Microgel translocation through pores under confinement. Angew Chem Int Ed 49(12):2193-2197. doi: 10.1002/anie.200906606
35. Smith MH, South AB, Gaulding JC, Lyon LA (2010) Monitoring the erosion of hydrolytically-degradable nanogels via multiangle light scattering coupled to asymmetrical flow field-flow fractionation. Anal Chem 82(2):523-530. doi: 10.1021/ac901725m
36. South AB, Lyon LA (2010) Direct observation of microgel erosion via in-liquid atomic force microscopy. Chem Mater 22(10):3300-3306. doi: 10.1021/cm100702p
37. Blackburn WH, Lyon LA (2008) Size-controlled synthesis of monodisperse core/shell nanogels. Colloid Polym Sci 286(5):563-569. doi: 10.1007/s00396-007- 1805-7
38. Berndt I, Richtering W (2003) Doubly temperature sensitive core-shell microgels. Macromolecules 36(23):8780-8785. doi: 10.1021/Ma034771+
39. Lapeyre V, Ancla C, Catargi B, Ravaine V (2008) Glucose-responsive microgels with a core-shell structure. J Colloid Interface Sci 327(2):316-323. doi: 10.1016/j.jcis.2008.08.039
40. Jones CD, Lyon LA (2003) Shell-restricted swelling and core compression in poly(N-isopropylacrylamide) core-shell microgels. Macromolecules 36(6):1988-1993. doi: 10.1021/Ma021079q
41. Berndt I, Pedersen JS, Lindner P, Richtering W (2006) Influence of shell thickness and cross-link density on the structure of temperature-sensitive poly-N-isopropylacrylamide-poly-N-isopropylmethacrylamide core-shell microgels investigated by small-angle neutron scattering. Langmuir 22(1):459-468. doi: 10.1021/la052463u
42. Berndt I, Popescu C, Wortmann FJ, Richtering W (2006) Mechanics versus thermodynamics: swelling in multiple-temperature-sensitive core-shell microgels. Angew Chem Int Ed 45(7):1081-1085. doi: 10.1002/anie.200502893
43. Gan DJ, Lyon LA (2001) Tunable swelling kinetics in core-shell hydrogel nanoparticles. J Am Chem Soc 123(31):7511-7517. doi: 10.1021/ja010609f