Differential expression of human beta defensin 2 and 3 in gastric mucosa of helicobacter pylori-infected individuals

Helicobacter

Volumn 18, Issue 1, 2013, Pages 6-12

  Bauer, Bianca ^a   Wex, Thomas ^b   Kuester, Doerthe ^b   Meyer, Thomas ^a   Malfertheiner, Peter ^b  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Antibacterial; Antibacterial peptide; Beta defensin; Gastritis; Gene expression; H. pylori

Indexed keywords

BETA DEFENSIN 2; BETA DEFENSIN 3;

ARTICLE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; ERADICATION THERAPY; EX VIVO STUDY; GASTRITIS; HELICOBACTER INFECTION; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ANTRUM; STOMACH MUCOSA; UPREGULATION;

BETA-DEFENSINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GASTRIC MUCOSA; GENE EXPRESSION PROFILING; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HISTOCYTOCHEMISTRY; HUMANS; REAL-TIME POLYMERASE CHAIN REACTION;

HELICOBACTER PYLORI;

EID: 84872371646     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/hel.12000     Document Type: Article

References (37)

1. Oppenheim JJ, Biragyn A, Kwak LW, Yang D. Roles of antimicrobial peptides such as defensins in innate and adaptive immunity. Ann Rheum Dis 2003;62(Suppl 2):ii17-21.
2. White SH, Wimley WC, Selsted ME. Structure, function, and membrane integration of defensins. Curr Opin Struct Biol 1995;5:521-7.
3. Yang D, Chertov O, Bykovskaia SN, et al. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999;286:525-8.
4. Röhrl J, Yang D, Oppenheim JJ, Hehlgans T. Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. J Immunol 2010;184:6688-94.
5. Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H. Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 2007;127:594-604.
6. Boniotto M, Tossi A, DelPero M, Sgubin S, Antcheva N, Santon D, Masters J, Crovella S. Evolution of the beta defensin 2 gene in primates. Genes Immun 2003;4:251-7.
7. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr. Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A 2002;99:2129-33.
8. Bals R. Epithelial antimicrobial peptides in host defense against infection. Respir Res 2000;1:141-50.
9. Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, Wilson JM. Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 1998;102:874-80.
10. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997;88:553-60.
11. Maisetta G, Batoni G, Esin S, Raco G, Bottai D, Favilli F, Florio W, Campa M. Susceptibility of Streptococcus mutans and Actinobacillus actinomycetemcomitans to bactericidal activity of human beta-defensin 3 in biological fluids. Antimicrob Agents Chemother 2005;49:1245-8.
12. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001;276:5707-13.
13. Dhople V, Krukemeyer A, Ramamoorthy A. The human beta-defensin-3, an antibacterial peptide with multiple biological functions. Biochim Biophys Acta 2006;1758:1499-512.
14. Kawauchi K, Yagihashi A, Tsuji N, Uehara N, Furuya D, Kobayashi D, Watanabe N. Human beta-defensin-3 induction in H. pylori-infected gastric mucosal tissues. World J Gastroenterol 2006;12:5793-7.
15. Boughan PK, Argent RH, Body-Malapel M, et al. Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection. J Biol Chem 2006;281:11637-48.
16. Wada A, Mori N, Oishi K, et al. Induction of human beta-defensin-2 mRNA expression by Helicobacter pylori in human gastric cell line MKN45 cells on cag pathogenicity island. Biochem Biophys Res Commun 1999;263:770-4.
17. O'Neil DA, Cole SP, Martin-Porter E, Housley MP, Liu L, Ganz T, Kagnoff MF. Regulation of human beta-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1. Infect Immun 2000;68:5412-5.
18. Bajaj-Elliott M, Fedeli P, Smith GV, Domizio P, Maher L, Ali RS, Quinn AG, Farthing MJ. Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis. Gut 2002;51:356-61.
19. Hamanaka Y, Nakashima M, Wada A, Ito M, Kurazono H, Hojo H, Nakahara Y, Kohno S, Hirayama T, Sekine I. Expression of human beta-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: antibacterial effect of hBD-2 against Helicobacter pylori. Gut 2001;49:481-7.
20. George JT, Boughan PK, Karageorgiou H, Bajaj-Elliott M. Host anti-microbial response to Helicobacter pylori infection. Mol Immunol 2003;40:451-6.
21. Hornsby MJ, Huff JL, Kays RJ, Canfield DR, Bevins CL, Solnick JV. Helicobacter pylori induces an antimicrobial response in rhesus macaques in a cag pathogenicity island-dependent manner. Gastroenterology 2008;134:1049-57.
22. Wada A, Ogushi K, Kimura T, et al. Helicobacter pylori-mediated transcriptional regulation of the human beta-defensin 2 gene requires NF-kappaB. Cell Microbiol 2001;3:115-23.
23. Grubman A, Kaparakis M, Viala J, et al. The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides. Cell Microbiol 2010;12:626-39.
24. Bauer B, Pang E, Holland C, Kessler M, Bartfeld S, Meyer TF. Helicobacter pylori CagA abrogates human ß-defensin 3 expression via SHP-2-dependent EGF receptor inactivation. Cell Host Microbe 2012;11:576-86.
25. Kandulski A, Malfertheiner P, Wex T. Role of regulatory T-cells in H. pylori-induced gastritis and gastric cancer. Anticancer Res 2010;30:1093-103.
26. Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterology 2009;136:1863-73.
27. Wex T, Ye S, Treiber G, Vieth M, Roessner A, Malfertheiner P. Helicobacter pylori infection, but not low-dose aspirin, results in a local reduction of the secretory leukocyte protease inhibitor in gastroduodenal mucosa. Helicobacter 2006;11:31-8.
28. Venerito M, Treiber G, Wex T, Kuester D, Roessner A, Di Mario F, Malfertheiner P. Effects of low-dose aspirin on gastric erosions, cyclooxygenase expression and mucosal prostaglandin-E2 do not depend on Helicobacter pylori infection. Aliment Pharmacol Ther 2006;23:1225-33.
29. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161-81.
30. Wex T, Venerito M, Kreutzer J, Götze T, Kandulski A, Malfertheiner P. Serological prevalence of Helicobacter pylori infection in Saxony-Anhalt, Germany, in 2010. Clin Vaccine Immunol 2011;18:2109-12.
31. Wex T, Treiber G, Lendeckel U, Malfertheiner P. A two-step method for the extraction of high-quality RNA from endoscopic biopsies. Clin Chem Lab Med 2003;41:1033-7.
32. Schwanhäusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, Chen W, Selbach M. Global quantification of mammalian gene expression control. Nature 2011;473:337-42.
33. Uehara N, Yagihashi A, Kondoh K, Tsuji N, Fujita T, Hamada H, Watanabe N. Human beta-defensin-2 induction in Helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpression. J Med Microbiol 2003;1:41-5.
34. Ohara T, Morishita T, Suzuki H, Masaoka T, Nishizawa T, Hibi T. Investigation of the possibility of human-beta defensin 2 (hBD2) as a molecular marker of gastric mucosal inflammation. Hepatogastroenterology 2005;52:1320-4.
35. Ohara T, Morishita T, Suzuki H, Masaoka T, Nagata H, Hibi T. Pathophysiological role of human beta-defensins 2 in gastric mucosa. Int J Mol Med 2004;14:1023-7.
36. Hollox EJ, Armour JA, Barber JC. Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Am J Hum Genet 2003;73:591-600.
37. Groth M, Wiegand C, Szafranski K, Huse K, Kramer M, Rosenstiel P, Schreiber S, Norgauer J, Platzer M. Both copy number and sequence variations affect expression of human DEFB4. Genes Immun 2010;11:458-66.