Double dissociation of the requirement for GluN2B-and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory

Journal of Neuroscience

Volumn 33, Issue 3, 2013, Pages 1109-1115

  Milton, Amy L ^a   Merlo, Emiliano ^a   Ratano, Patrizia ^a   Gregory, Ben L ^a   Dumbreck, Jessica K ^a   Everitt, Barry J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 2A; GLUTAMATE RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOLATERAL AMYGDALA; BEHAVIOR CHANGE; DOUBLE DISSOCIATION; HISTOLOGY; MALE; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMYGDALA; ANIMALS; ANISOMYCIN; ASSOCIATION LEARNING; EXCITATORY AMINO ACID ANTAGONISTS; FEAR; MALE; MEMORY; PIPERIDINES; PROTEIN SYNTHESIS INHIBITORS; QUINOXALINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84872363947     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3273-12.2013     Document Type: Article

References (47)

1. Auberson YP, Allgeier H, Bischoff S, Lingenhoehl K, Moretti R, Schmutz M (2002) 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett 12:1099-1102. CrossRef Medline
2. Bast T, da Silva BM, Morris RGM (2005) Distinct contributions of hippocampal NMDA and AMPA receptors to encoding and retrieval of one-trial place memory. J Neurosci 25:5845-5856. CrossRef Medline
3. Ben Mamou C, Gamache K, Nader K (2006) NMDA receptors are critical for unleashing consolidated auditory fear memories. Nat Neurosci 9:1237-1239. CrossRef Medline
4. Bingol B, Wang CF, Arnott D, Cheng D, Peng J, Sheng M (2010) Autophosphorylated CaMKII acts as a scaffold to recruit proteasomes to dendritic spines. Cell 140:567-578. CrossRef Medline
5. Brown TE, Lee BR, Sorg BA (2008) The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem 15:857-865. CrossRef Medline
6. Campeau S, Davis M (1995) Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 15:2301-2311. Medline
7. Cardinal RN, Aitken MRF (2006) ANOVA for the behavioural sciences researcher. London: Lawrence Erlbaum.
8. Dalton GL, Wu DC, Wang YT, Floresco SB, Phillips AG (2012) NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear. Neuropharmacology 62:797-806. CrossRef Medline
9. Davis S, Butcher SP, Morris RG (1992) The NMDA antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci 12:21-34. Medline
10. Day M, Langston R, Morris RGM (2003) Glutamate-receptor-mediated encoding and retrieval of paired-associate learning. Nature 424:205-209. CrossRef Medline
11. De Vry J, Jentzsch KR (2003) Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine. Behav Pharmacol 14: 229-235. CrossRef Medline
12. Di Ciano P, Everitt BJ (2004) Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by rats. J Neurosci 24:7167-7173. CrossRef Medline
13. Dingledine R, Borges K, Bowie D, Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51:7-61. Medline
14. Doherty AJ, Coutinho V, Collingridge GL, Henley JM (1999) Rapid inter-nalization and surface expression of a functional, fluorescently tagged G-protein-coupled glutamate receptor. Biochem J 341:415-422. CrossRef Medline
15. Fanselow MS, Kim JJ (1994) Acquisition of contextual pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala. Behav Neurosci 108:210-212. CrossRef Medline
16. Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-414. CrossRef Medline
17. Hu M, Sun YJ, Zhou QG, Auberson YP, Chen L, Hu Y, Luo CX, Wu JY, Zhu DY, Li LX (2009) Reduced spatial learning in mice treated with NVP-AAM077 through downregulating neurogenesis. Eur J Pharmacol 622:37-44. CrossRef Medline
18. Itzhak Y (2008) Role of the NMDA receptor and nitric oxide in memory reconsolidation of cocaine-induced conditioned place preference in mice. Ann N Y Acad Sci 1139:350-357. CrossRef Medline
19. Ivanov A, Pellegrino C, Rama S, Dumalska I, Salyha Y, Ben-Ari Y, Medina I (2006) Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-related kinases (ERK) activity in cultured rat hippocampal neurons. J Physiol 572:789-798. CrossRef Medline
20. Killcross S, Robbins TW, Everitt BJ (1997) Different types of fearconditioned behaviour mediated by separate nuclei within amygdala. Nature 388:377-380. CrossRef Medline
21. Kim MJ, Dunah AW, Wang YT, Sheng M (2005) Differential roles of NR2A-and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. Neuron 46:745-760. CrossRef Medline
22. Kocsis B (2012) Differential role of NR2A and NR2B subunits in N-methyl-D-aspartate receptor antagonist-induced aberrant cortical gamma oscillations. Biol Psychiatry 71:987-995. CrossRef Medline
23. Koo JW, Han JS, Kim JJ (2004) Selective neurotoxic lesions of basolateral and central nuclei of the amygdala produce differential effects on fear conditioning. J Neurosci 24:7654-7662. CrossRef Medline
24. Lee JL, Everitt BJ (2008) Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmission. Neurobiol Learn Mem 90:147-154. CrossRef Medline
25. Lee JLC, Milton AL, Everitt BJ (2006) Reconsolidation and extinction of conditioned fear: inhibition and potentiation. J Neurosci 26: 10051-10056. CrossRef Medline
26. Lee SH, Choi JH, Lee N, Lee HR, Kim JI, Yu NK, Choi SL, Lee SH, Kim H, Kaang BK (2008) Synaptic protein degradation underlies destabilization of retrieved fear memory. Science 319:1253-1256. CrossRef Medline
27. Lewis DJ (1979) Psychobiology of active and inactive memory. Psychol Bull 86:1054-1083. CrossRef Medline
28. Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, Auberson YP, Wang YT (2004) Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304:1021-1024. CrossRef Medline
29. Martel MA, Ryan TJ, Bell KFS, Fowler JH, McMahon A, Al-Mubarak B, Komiyama NH, Horsburgh K, Kind PC, Grant SGN, Wyllie DJA, Hardingham GE (2012) The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron 74:543-556. CrossRef Medline
30. Milton AL, Everitt BJ (2010) The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction. Eur J Neurosci 31:2308-2319. CrossRef Medline
31. Milton AL, Lee JLC, Butler VJ, Gardner R, Everitt BJ (2008) Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviors. J Neurosci 28:8230-8237. CrossRef Medline
32. Milton AL, Schramm MJW, Wawrzynski JR, Gore F, Oikonomou-Mpegeti F, Wang NQ, Samuel D, Economidou D, Everitt BJ (2012) Antagonism at NMDA receptors, but not-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli. Psychopharmacology 219:751-761. CrossRef Medline
33. Morris RG, Anderson E, Lynch GS, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-Daspartate receptor antagonist, AP5. Nature 319:774-776. CrossRef Medline
34. Muller T, Albrecht D, Gebhardt C (2009) Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice. Learn Mem 16:395-405. CrossRef Medline
35. Nader K (2003) Memory traces unbound. Trends Neurosci 26:65-72. CrossRef Medline
36. Nader K, Schafe GE, Le Doux JE (2000) Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406: 722-726. CrossRef Medline
37. Ornstein PL, Arnold MB, Augenstein NK, Lodge D, Leander JD, Schoepp DD (1993) (3SR,4aRS,6 RS,8aRS)-6-[2-(1 H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist. J Med Chem 36:2046-2048. CrossRef Medline
38. Paxinos G, Watson C (2004) The rat brain in stereotaxic co-ordinates, Ed 4. New York: Academic.
39. Pedreira ME, Pérez-Cuesta LM, Maldonado H (2002) Reactivation and reconsolidation of long-term memory in the crab Chasmagnathus: protein synthesis requirement and mediation by NMDA-type glutamatergic receptors. J Neurosci 22:8305-8311. Medline
40. Przybyslawski J, Sara SJ (1997) Reconsolidation of memory after its reactivation. Behav Brain Res 84:241-246. CrossRef Medline
41. Sadler R, Herzig V, Schmidt WJ (2007) Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference. Behav Pharmacol 18: 699-703. CrossRef Medline
42. von der Goltz C, Vengeliene V, Bilbao A, Perreau-Lenz S, Pawlak CR, Kiefer F, Spanagel R (2009) Cue-induced alcohol seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology 205:389-397. CrossRef Medline
43. Walker DL, Davis M (2008) Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test. Learn Mem 15:67-74. CrossRef Medline
44. Walker DL, Rattiner LM, Davis M (2002) Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats. Behav Neurosci 116:1075-1083. CrossRef Medline
45. Williams K (1993) Ifenprodil discriminates subtypes of the N-methyl-Daspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol 44:851-859. Medline
46. Winters BD, Bussey TJ (2005) Glutamate receptors in perirhinal cortex mediate encoding, retrieval and consolidation of object recognition memory. J Neurosci 25:4243-4251. CrossRef Medline
47. Zhang XH, Liu F, Chen Q, Zhang CL, Zhuo M, Xiong ZQ, Li BM (2008) Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory. Neuropharmacology 55:238-246. CrossRef Medline