Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition

Acta Neuropathologica

Volumn 125, Issue 1, 2013, Pages 159-168

  Prada, Carlos E ^a,b   Jousma, Edwin ^a   Rizvi, Tilat A ^a   Wu, Jianqiang ^a   Scott Dunn, R ^a   Mayes, Debra A ^a   Cancelas, Jose A ^a   Dombi, Eva ^c   Kim, Mi Ok ^a   West, Brian L ^d   Bollag, Gideon ^d   Ratner, Nancy ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b Cardiovascular Foundation of Colombia   (Colombia)

^c NATIONAL CANCER INSTITUTE   (United States)

^d PLEXXIKON INC   (United States)

Author keywords

c kit; Fms; Macrophages; Minocycline; Mouse model; Neurofibromatosis type 1; Neurofibromin

Indexed keywords

ANTINEOPLASTIC AGENT; CD163 ANTIGEN; MINOCYCLINE; PLX 3397; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG RESPONSE; DRUG TISSUE LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION INHIBITION; MOUSE; NERVE SHEATH TUMOR; NEUROFIBROMA; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; SCHWANN CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; TUMOR VOLUME;

AGE FACTORS; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; MACROPHAGES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROFIBROMA; NEUROFIBROMIN 1; NEURONS; SCHWANN CELLS; TUMOR BURDEN;

EID: 84872351805     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-1056-7     Document Type: Article

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