Effect of pcdna3.1-vascular endothelial growth factor 165 recombined vector on vascular buds in rabbit vertebral cartilage endplate

Chinese Medical Journal

Volumn 125, Issue 22, 2012, Pages 4055-4060

  Hong Guang, Xu ^a   Xiao Hu, Chen ^a   Guo Zheng, Ding ^a   Hong, Wang ^a   Ling Ting, Wang ^a   Xue Wu, Chen ^a  

^a WANNAN MEDICAL COLLEGE   (China)

Author keywords

Vascular corrosion casting; Vascular endothelial growth factor; Vertebral cartilage endplate

Indexed keywords

STYRENE DERIVATIVE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANKYLOSING HYPEROSTOSIS; ARTICLE; CONTROLLED STUDY; HISTOLOGY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; LUMBAR VERTEBRA; NONHUMAN; NUCLEUS PULPOSUS; RABBIT; SCANNING ELECTRON MICROSCOPY; SKELETON RADIOGRAPHY;

ANIMALS; FEMALE; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISC DISPLACEMENT; MALE; MICROSCOPY, ELECTRON, SCANNING; PLASMIDS; RABBITS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84872343766     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2012.22.026     Document Type: Article

References (30)

1. Zhang Y, Chee A, Thonar EJ, An HS. Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine. PMR 2011; 3: S88-S94.
2. Ferguson SJ, Ito K, Nolte LP. Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech 2004; 37: 213-221.
3. Gantenbein B, Grünhagen T, Lee CR, van Donkelaar CC, Alini M, Ito K. An in vitro organ culturing system for intervertebral disc explants with vertebral endplates: a feasibility study with ovine caudal discs. Spine 2006; 31: 2665-2673.
4. van der Werf M, Lezuo P, Maissen O, van Donkelaar CC, Ito K. Inhibition of vertebral endplate perfusion results in decreased intervertebral disc intranuclear diffusive transport. J Anat 2007; 211: 769-774.
5. Horner HA, Urban JP. 2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine 2001; 26: 2543-2549.
6. Bibby SR, Jones DA, Ripley RM, Urban JP. Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine 2005; 30: 487-496.
7. Rennel ES, Varey AH, Churchill AJ, Wheatley ER, Stewart L, Mather S, et al. VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo. Br J Cancer 2009; 101: 1183-1193.
8. Petersen W, Tsokos M, Pufe T. Expression of VEGF121 and VEGF165 in hypertrophic chondrocytes of the human growth plate and epiphyseal cartilage. J Anat 2002; 201: 153-157.
9. Xu H, Chen X, Lu L, Wang H, Liu P, Ding G Expression of transforming growth factor-p1 and vascular endothelial cell growth factor in the cartilaginous endplates of centrum with cervical spondylosis. Anat Clin 2008; 13: 322-324.
10. Haschtmann D, Stoyanov JV, Gédet P, Ferguson SJ. Vertebral endplate trauma induces disc cell apoptosis and promotes organ degeneration in vitro. Eur Spine J 2008; 17: 289-299.
11. Boyd LM, Carter AJ. Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc. Eur Spine J 2006; 15: s414-s421.
12. Zhao S, Ma D, Dai H, Yuan F, Wang Z. Biologically inhibitory effects of VEGF siRNA on endometrial carcinoma cells. Arch Gynecol Obstet 2011; 284: 1533-1541.
13. Bendtsen M, Bünger CE, Zou X, Foldager C, Jørgensen HS. Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration. Spine 2011; 36: E373-E379.
14. Xu H, Chen X, Wang H, Wang L, Chen X. Morphologic differences of vascular buds in vertebral cartilage endplate in age-specific rabbits. Chin J Orthop (Chin) 2011; 31: 351-356.
15. Urban JP, Holm S, Maroudas A, Nachemson A. Nutrition of the intervertebral disc. An in vivo study of solute transport. Clin Orthop Relat Res 1977; 129: 101-114.
16. Oki S, Matsuda Y, Shibata T, Okumura H, Desaki J. Morphologic differences of the vascular buds in the vertebral endplate: scanning electron microsopic study. Spine 1996; 21: 174-177.
17. Xu HG, Chen XW, Wang H, Lu LM, Liu P, Xia LZ. Correlation between chondrocyte apoptosis of vertebral cartilage endplate and degeneration of intervertebral disc. Natl Med J China (Chin) 2008; 88: 194-197.
18. Rutges J P, Jagt van der O P, Oner FC, Verbout AJ, Castelein RJ, Kummer JA, et al. Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration. Osteoarthritis Cartilage 2011; 19: 89-95.
19. Urban JP, Holm S, Maroudas A. Diffusion of small solutes into the intervertebral disc: an in vivo study. Biorheology 1978; 15: 203-221.
20. Altavilla D, Saitta A, Cucinotta D, Galeano M, Deodato B, Colonna M, et al. Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes 2001; 50: 667-674.
21. Pakos EE, Goussia AC, Tsekeris PG, Papachristou DJ, Stefanou D, Agnantis NJ. Expression of vascular endothelial growth factor and its receptor, KDR/Flk-1, in soft tissue sarcomas. Anticancer Res 2005; 25: 3591-3596.
22. Byrne AM, Bouchier-Hayes DJ, Harmey JH. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Mol Med 2005; 9: 777-794.
23. Geiger F, Bertram H, Berger I, Lorenz H, Wall O, Eckhardt C, et al. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 2005; 20: 2028-2035.
24. Guan H, Zhou Z, Wang H, Jia SF, Liu W, Kleinerman ES. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 2005; 11: 2662-2669.
25. Iwaguro H, Yamaguchi J, Kalka C, Murasawa S, Masuda H, Hayashi S, et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 2002; 105: 732-738.
26. Lee LY, Patel SR, Hackett NR, Mack CA, Polce DR, El-Sawy T, et al. Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121. Ann Thorac Surg 2000; 69: 14-24.
27. Vera Janavel G, Crottogini A, Cabeza Meckert P, Cuniberti L, Mele A, Papouchado M, et al. Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheep. Gene Ther 2006; 13: 1133-1142.
28. Golub JS, Kim YT, Duvall CL, Bellamkonda RV, Gupta D, Lin AS, et al. Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. Am J Physiol Heart Circ Physiol 2010; 298: H1959-H1965.
29. Wang H, Chen W, Xu H, Ding G, Liu P, Huang D, et al. Correlation between VEGF and HIF-1α expression in vertebral cartilage endplate of cervical spondylosis patients. J Pract Med (Chin) 2008; 24: 2745-2747.
30. Kokubo Y, Uchida K, Kobayashi S, Yayama T, Sato R, Nakajima H, et al. Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples. Laboratory investigation. J Neurosurg Spine 2008; 9: 285-295.